Reactome | UniProt:P07703 RPC40

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UniProt:P07703 RPC40 Show undefined attributes

chain	initiator methionine:1 chain:2-335
checksum	76A5D6784403E990
comment	FUNCTION DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I (Pol I) and III (Pol III) which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPC40 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft (PubMed:18160037, PubMed:24153182, PubMed:24153184). Plays an important role in targeting retrotransposons Ty integration upstream of pol III-transcribed genes such as tRNA genes, allowing Ty1, Ty2 and Ty4 to proliferate and yet minimizing genetic damage (PubMed:25931562).SUBUNIT Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34 (PubMed:11717393, PubMed:12407181, PubMed:18160037, PubMed:24153182, PubMed:24153184, PubMed:8516295). The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA. Component of the RNA polymerase III (Pol III) complex consisting of at least 17 subunits (PubMed:10384303, PubMed:10393904, PubMed:8516295). Interacts with the RPC19/RPAC2 (PubMed:8516295) and RPC53/RPC4 (PubMed:10393904). Interacts with retrotransposons Ty integrase, targeting Ty1, Ty2 and Ty4 integration upstream of pol III-transcribed genes (PubMed:25931562).INTERACTION Present with 13000 molecules/cell in log phase SD medium.SIMILARITY Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
crossReference	[DatabaseIdentifier:12138678] PDB:7Z1N [DatabaseIdentifier:12429359] RefSeq:NP_015435.1 [DatabaseIdentifier:12252927] PRO:P07703 [DatabaseIdentifier:12138690] PDB:8BWS [DatabaseIdentifier:12163335] PDB:6TPS [DatabaseIdentifier:12163314] PDB:4YM7 [DatabaseIdentifier:12138683] PDB:7Z1L [DatabaseIdentifier:12163337] PDB:6HLS [DatabaseIdentifier:12163313] PDB:5G5L [DatabaseIdentifier:12163351] PDB:9G23 [DatabaseIdentifier:12163338] PDB:6HLR [DatabaseIdentifier:12138666] PDB:7Z0H [DatabaseIdentifier:12163323] PDB:5N60 [DatabaseIdentifier:12138685] PDB:5FJA [DatabaseIdentifier:12163339] PDB:6HLQ [DatabaseIdentifier:12163319] PDB:5W66 [DatabaseIdentifier:12163307] PDB:6RRD [DatabaseIdentifier:12138675] PDB:6F42 [DatabaseIdentifier:12138671] PDB:6EU3 [DatabaseIdentifier:12138688] PDB:7Z30 [DatabaseIdentifier:12163320] PDB:5W5Y [DatabaseIdentifier:12163348] PDB:6RQL [DatabaseIdentifier:12163322] PDB:5N5Z [DatabaseIdentifier:12163349] PDB:9G1X [DatabaseIdentifier:12163350] PDB:9G29 [DatabaseIdentifier:12163318] PDB:5W64 [DatabaseIdentifier:12138682] PDB:6TUT [DatabaseIdentifier:12163336] PDB:6HKO [DatabaseIdentifier:12138674] PDB:6F40 [DatabaseIdentifier:12138670] PDB:6EU0 [DatabaseIdentifier:12138684] PDB:7Z1M [DatabaseIdentifier:12163327] PDB:5M3F [DatabaseIdentifier:12138676] PDB:6CNB [DatabaseIdentifier:12138686] PDB:7Z2Z [DatabaseIdentifier:12138680] PDB:7Z1O [DatabaseIdentifier:12163346] PDB:6RQH [DatabaseIdentifier:12163326] PDB:4C2M [DatabaseIdentifier:11500526] ENSEMBL:YPR110C [DatabaseIdentifier:11610661] ENSEMBL:YPR110C [DatabaseIdentifier:11733360] ENSEMBL:YPR110C_mRNA [DatabaseIdentifier:12163334] PDB:5M64 [DatabaseIdentifier:12163321] PDB:5N5Y [DatabaseIdentifier:12163309] PDB:6RUI [DatabaseIdentifier:12163347] PDB:9G24 [DatabaseIdentifier:12163329] PDB:4C3I [DatabaseIdentifier:12163324] PDB:5M3M [DatabaseIdentifier:12138689] PDB:7Z31 [DatabaseIdentifier:12163325] PDB:5N61 [DatabaseIdentifier:12163310] PDB:6RUO [DatabaseIdentifier:12163312] PDB:5LMX [DatabaseIdentifier:12138679] PDB:6CNC [DatabaseIdentifier:12163343] PDB:9G26 [DatabaseIdentifier:12163328] PDB:4C3H [DatabaseIdentifier:12163308] PDB:5OA1 [DatabaseIdentifier:12163342] PDB:6RQT [DatabaseIdentifier:12138672] PDB:6F41 [DatabaseIdentifier:12138669] PDB:6EU1 [DatabaseIdentifier:12138677] PDB:6CND [DatabaseIdentifier:12138681] PDB:6CNF [DatabaseIdentifier:12138668] PDB:6F44 [DatabaseIdentifier:12163315] PDB:6H67 [DatabaseIdentifier:12163317] PDB:5W65 [DatabaseIdentifier:12138673] PDB:6EU2 [DatabaseIdentifier:12163345] PDB:9G27 [DatabaseIdentifier:12163331] PDB:5M5X [DatabaseIdentifier:12138667] PDB:5FJ8 [DatabaseIdentifier:12138687] PDB:5FJ9 [DatabaseIdentifier:12163333] PDB:5M5Y [DatabaseIdentifier:12163344] PDB:9G1V [DatabaseIdentifier:12163332] PDB:5M5W [DatabaseIdentifier:12163330] PDB:4C3J [DatabaseIdentifier:12163341] PDB:9G2C [DatabaseIdentifier:12163311] PDB:6RWE [DatabaseIdentifier:12163340] PDB:9G2B [DatabaseIdentifier:12163316] PDB:6H68
databaseName	UniProt
dbId	100525
description	recommendedName: fullName evidence="12"DNA-directed RNA polymerases I and III subunit RPAC1 shortName evidence="12"RNA polymerases I and III subunit AC1 alternativeName: C37 alternativeName: fullName evidence="11"DNA-directed RNA polymerases I and III 40 kDa polypeptide shortName evidence="11"AC40 shortName evidence="12"C40
displayName	UniProt:P07703 RPC40
geneName	RPC40 RPC5 YPR110C P8283.18
identifier	P07703
isSequenceChanged	false
keyword	3D-structure Acetylation DNA-directed RNA polymerase Nucleus Phosphoprotein Reference proteome Ribosome biogenesis Transcription
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPC40
otherIdentifier	856226 GO:0000428 GO:0001054 GO:0003677 GO:0003899 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005666 GO:0005730 GO:0005736 GO:0006351 GO:0006352 GO:0006353 GO:0006354 GO:0006360 GO:0006361 GO:0006362 GO:0006363 GO:0006383 GO:0006384 GO:0006386 GO:0016740 GO:0016779 GO:0042254 GO:0042790 GO:0042797 GO:0046983 GO:0070893
physicalEntity	[EntityWithAccessionedSequence:R-SCE-63498] RPC40 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-111824] RPC5_YEAST [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11365820] BioGPS Gene:856226 RPC40 [ReferenceDNASequence:12703005] UCSC:P07703 RPC40 [ReferenceDNASequence:11904298] KEGG:sce:YPR110C RPC40 [ReferenceDNASequence:11995609] Monarch:856226 RPC40 [ReferenceDNASequence:12079702] NCBI Gene:856226 RPC40
referenceTranscript	[ReferenceRNASequence:12610879] RefSeq:NM_001184207.1 RPC40
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RPAC1_YEAST D6W4A9
sequenceLength	335
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P07703
url	http://purl.uniprot.org/uniprot/P07703

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-SCE-63498] RPC40 [nucleoplasm] [EntityWithAccessionedSequence:R-SCE-111824] RPC5_YEAST [nucleoplasm]
(interactor)	[UndirectedInteraction:11151203] UniProt:P41910 <-> UniProt:P07703 (IntAct) [UndirectedInteraction:11190461] UniProt:Q00684 <-> UniProt:P07703 (IntAct) [UndirectedInteraction:11225045] UniProt:P22147 <-> UniProt:P07703 (IntAct)

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