UniProt:P07477 PRSS1

chain
  • signal peptide:1-15
  • propeptide:16-23
  • chain:24-247
  • chain:24-122
  • chain:123-247
checksum DD49A487B8062813
comment
  • FUNCTION Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.CATALYTIC ACTIVITY Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.COFACTOR Binds 1 Ca(2+) ion per subunit.SUBUNIT Interacts with SERPINA1.SUBCELLULAR LOCATION Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.PTM Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.MASS SPECTROMETRY Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase S1 family.CAUTION Tyr-154 was proposed to be phosphorylated (PubMed:8683601) but it has been shown (PubMed:17087724) to be sulfated instead. Phosphate and sulfate groups are similar in mass and size, and this can lead to erroneous interpretation of the results.
crossReference
databaseName UniProt
dbId 66483
description
  • recommendedName: fullName evidence="26"Serine protease 1 ecNumber: 3.4.21.4 alternativeName: fullName evidence="2"Anionic trypsin I alternativeName: fullName evidence="2"Anionic trypsin-I alternativeName: Beta-trypsin alternativeName: Cationic trypsinogen alternativeName: fullName evidence="2"Pretrypsinogen I alternativeName: fullName evidence="26"Trypsin I alternativeName: Trypsin-1 component recommendedName: Alpha-trypsin chain 1 /component component recommendedName: Alpha-trypsin chain 2 /component
displayName UniProt:P07477 PRSS1
geneName
  • PRSS1
  • TRP1
  • TRY1
  • TRYP1
identifier P07477
isSequenceChanged false
keyword
  • 3D-structure
  • Calcium
  • Digestion
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Hydrolase
  • Metal-binding
  • Protease
  • Proteomics identification
  • Reference proteome
  • Secreted
  • Serine protease
  • Signal
  • Sulfation
  • Zymogen
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • PRSS1
otherIdentifier
  • 11716820_x_at
  • 11760149_a_at
  • 11760150_x_at
  • 17052652
  • 205869_PM_at
  • 205869_at
  • 3028758
  • 3028759
  • 3028762
  • 3028764
  • 3028767
  • 3028768
  • 3028769
  • 3028771
  • 3028772
  • 3028773
  • 3028774
  • 3028775
  • 3028776
  • 3028777
  • 3028778
  • 3028779
  • 3028780
  • 3028781
  • 3028782
  • 3028784
  • 3028786
  • 3028789
  • 3028792
  • 3028795
  • 3028799
  • 3028807
  • 3028819
  • 3167210
  • 3167212
  • 3167215
  • 3203657
  • 32796_f_at
  • 5644
  • 8136795
  • A_23_P380754
  • GO:0004252
  • GO:0005576
  • GO:0005615
  • GO:0006508
  • GO:0007586
  • GO:0008233
  • GO:0008236
  • GO:0016787
  • GO:0022617
  • GO:0030141
  • GO:0030198
  • GO:0030312
  • GO:0031012
  • GO:0046872
  • GO:0072562
  • HMNXSV003013589
  • ILMN_1734773
  • M22612_f_at
  • PH_hs_0040453
  • TC07003345.hg
  • g4506144_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TRY1_HUMAN
  • A1A509
  • A6NJ71
  • B2R5I5
  • Q5NV57
  • Q7M4N3
  • Q7M4N4
  • Q92955
  • Q9HAN4
  • Q9HAN5
  • Q9HAN6
  • Q9HAN7
sequenceLength 247
species [Species:48887] Homo sapiens
stId uniprot:P07477
url http://purl.uniprot.org/uniprot/P07477
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