Reactome | UniProt:P07280 RPS19A

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UniProt:P07280 RPS19A Show undefined attributes

chain	initiator methionine:1 chain:2-144
checksum	FE06D94B993B11B2
comment	FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS19 is required for proper maturation of the small (40S) ribosomal subunit. Binds to 40S pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA (PubMed:16159874, PubMed:17726054).SUBUNIT Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:22096102, PubMed:9559554).SUBCELLULAR LOCATION Disruption of a single RPS19 gene reduces cell growth; a double disruption is lethal. Depletion experiments show the proteins are required for correct maturation of precursor rRNA to generate the 18S small rRNA. A specific site between the 18S and 5.8S precursors (site A2 in ETS1) is not cleaved in disruption mutants. Partially assembled ribosomes are retained in the nucleolus rather than being exported to the cytoplasm. All effects are exacerbated in the double disruption. Increases association of NOC4 with 20S/21S pre-rRNA, decreases association of ENP1, TSR1 and RIO2 with 20S/21S pre-rRNA.MISCELLANEOUS Present with 29000 molecules/cell in log phase SD medium.MISCELLANEOUS There are 2 genes for eS19 in yeast.SIMILARITY Belongs to the eukaryotic ribosomal protein eS19 family.
crossReference	[DatabaseIdentifier:12142290] PDB:4V7R [DatabaseIdentifier:12425406] RefSeq:NP_014520.1 [DatabaseIdentifier:12250957] PRO:P07280 [DatabaseIdentifier:12142394] PDB:5TGA [DatabaseIdentifier:12142407] PDB:6T4Q [DatabaseIdentifier:12142386] PDB:8BQX [DatabaseIdentifier:12142403] PDB:5DGE [DatabaseIdentifier:12142370] PDB:8T3D [DatabaseIdentifier:12142379] PDB:8EVP [DatabaseIdentifier:12142385] PDB:8CCS [DatabaseIdentifier:12142375] PDB:8T2X [DatabaseIdentifier:12142419] PDB:4V6I [DatabaseIdentifier:12142390] PDB:7A1G [DatabaseIdentifier:12142396] PDB:8PNN [DatabaseIdentifier:12142410] PDB:4U50 [DatabaseIdentifier:12142408] PDB:4U4N [DatabaseIdentifier:12142389] PDB:8CKU [DatabaseIdentifier:12141517] PDB:6EML [DatabaseIdentifier:12142377] PDB:8T2Y [DatabaseIdentifier:12142384] PDB:6Z6J [DatabaseIdentifier:12142383] PDB:8P4V [DatabaseIdentifier:12142400] PDB:5DGV [DatabaseIdentifier:12141513] PDB:6FAI [DatabaseIdentifier:12142404] PDB:5DGF [DatabaseIdentifier:12142395] PDB:5FCJ [DatabaseIdentifier:12141687] PDB:7AJU [DatabaseIdentifier:12142398] PDB:8CDR [DatabaseIdentifier:12142366] PDB:8T3E [DatabaseIdentifier:12151276] PDB:6ZQF [DatabaseIdentifier:12142382] PDB:6Z6K [DatabaseIdentifier:12142421] PDB:8CEH [DatabaseIdentifier:12142417] PDB:4U53 [DatabaseIdentifier:12141692] PDB:6ZQD [DatabaseIdentifier:12142425] PDB:7ZUX [DatabaseIdentifier:12142416] PDB:4U4R [DatabaseIdentifier:12142415] PDB:7ZW0 [DatabaseIdentifier:12142393] PDB:8K2D [DatabaseIdentifier:12142412] PDB:5NDG [DatabaseIdentifier:12142409] PDB:4U4O [DatabaseIdentifier:12142378] PDB:5OBM [DatabaseIdentifier:12142426] PDB:7ZUW [DatabaseIdentifier:12142405] PDB:8CF5 [DatabaseIdentifier:12142392] PDB:6GQB [DatabaseIdentifier:12142374] PDB:6WOO [DatabaseIdentifier:12142365] PDB:8EVR [DatabaseIdentifier:12142422] PDB:4U3U [DatabaseIdentifier:12154684] PDB:6ZQG [DatabaseIdentifier:12142414] PDB:4U52 [DatabaseIdentifier:12142418] PDB:5M1J [DatabaseIdentifier:12142402] PDB:5FCI [DatabaseIdentifier:12142371] PDB:8ZGR [DatabaseIdentifier:12142369] PDB:8T3C [DatabaseIdentifier:12142401] PDB:8CDL [DatabaseIdentifier:12142380] PDB:7ZRS [DatabaseIdentifier:12142413] PDB:4U4Q [DatabaseIdentifier:12142397] PDB:4U3M [DatabaseIdentifier:12142367] PDB:8T3F [DatabaseIdentifier:12142424] PDB:5TGM [DatabaseIdentifier:12142381] PDB:8T2Z [DatabaseIdentifier:12142388] PDB:6GQV [DatabaseIdentifier:12141682] PDB:6ZQE [DatabaseIdentifier:12142372] PDB:8ZH3 [DatabaseIdentifier:12142368] PDB:6TB3 [DatabaseIdentifier:12142411] PDB:4U51 [DatabaseIdentifier:12142423] PDB:5ON6 [DatabaseIdentifier:12142391] PDB:8XU8 [DatabaseIdentifier:12142420] PDB:8CMJ [DatabaseIdentifier:12142399] PDB:4U3N [DatabaseIdentifier:12142351] PDB:8ZHB [DatabaseIdentifier:12142361] PDB:8T3B [DatabaseIdentifier:12141695] PDB:7D63 [DatabaseIdentifier:12142345] PDB:6SNT [DatabaseIdentifier:12141678] PDB:7D4I [DatabaseIdentifier:12142344] PDB:7MPI [DatabaseIdentifier:12141516] PDB:8C01 [DatabaseIdentifier:12142340] PDB:8T30 [DatabaseIdentifier:12139503] PDB:6ZU9 [DatabaseIdentifier:12142298] PDB:5MC6 [DatabaseIdentifier:12142310] PDB:4V92 [DatabaseIdentifier:12142362] PDB:6XIR [DatabaseIdentifier:12142319] PDB:4V88 [DatabaseIdentifier:12142350] PDB:8EWC [DatabaseIdentifier:12142292] PDB:8CG8 [DatabaseIdentifier:12142330] PDB:5TBW [DatabaseIdentifier:12142347] PDB:3J6X [DatabaseIdentifier:12142311] PDB:8UT0 [DatabaseIdentifier:12142327] PDB:5MEI [DatabaseIdentifier:12142317] PDB:6WDR [DatabaseIdentifier:12142329] PDB:6T7I [DatabaseIdentifier:12142312] PDB:6Q8Y [DatabaseIdentifier:12142355] PDB:6ZVI [DatabaseIdentifier:12142325] PDB:6HHQ [DatabaseIdentifier:12142356] PDB:8ZGY [DatabaseIdentifier:12142313] PDB:5DC3 [DatabaseIdentifier:12140536] PDB:8YLR [DatabaseIdentifier:12142322] PDB:9F9S [DatabaseIdentifier:12142349] PDB:8EWB [DatabaseIdentifier:12142320] PDB:5DAT [DatabaseIdentifier:12142338] PDB:8Z70 [DatabaseIdentifier:12142321] PDB:6TNU [DatabaseIdentifier:12141515] PDB:6Y7C [DatabaseIdentifier:12142359] PDB:8T3A [DatabaseIdentifier:12141514] PDB:8C00 [DatabaseIdentifier:12142333] PDB:8P9A [DatabaseIdentifier:12142328] PDB:8UTI [DatabaseIdentifier:12142314] PDB:8CGN [DatabaseIdentifier:12142309] PDB:6SV4 [DatabaseIdentifier:12144970] PDB:8Y0U [DatabaseIdentifier:12139514] PDB:6ZCE [DatabaseIdentifier:12142346] PDB:3J78 [DatabaseIdentifier:12141519] PDB:8CBJ [DatabaseIdentifier:12142360] PDB:8EVT [DatabaseIdentifier:12142336] PDB:4V8Z [DatabaseIdentifier:12142315] PDB:4U6F [DatabaseIdentifier:12140531] PDB:7B7D [DatabaseIdentifier:12142291] PDB:6RBE [DatabaseIdentifier:12142299] PDB:5NDV [DatabaseIdentifier:12142324] PDB:8EUB [DatabaseIdentifier:12142316] PDB:8BN3 [DatabaseIdentifier:12142354] PDB:6GQ1 [DatabaseIdentifier:12142332] PDB:8K82 [DatabaseIdentifier:12142342] PDB:7NRC [DatabaseIdentifier:11498533] ENSEMBL:YOL121C [DatabaseIdentifier:11607851] ENSEMBL:YOL121C [DatabaseIdentifier:11730550] ENSEMBL:YOL121C_mRNA [DatabaseIdentifier:12142352] PDB:8BQD [DatabaseIdentifier:12142364] PDB:6XIQ [DatabaseIdentifier:12142339] PDB:8CIV [DatabaseIdentifier:12142293] PDB:5JUP [DatabaseIdentifier:12139511] PDB:8CAH [DatabaseIdentifier:12142343] PDB:7NRD [DatabaseIdentifier:12142353] PDB:8ZHC [DatabaseIdentifier:12142363] PDB:8EVQ [DatabaseIdentifier:12142300] PDB:6I7O [DatabaseIdentifier:12139510] PDB:8CAS [DatabaseIdentifier:12142335] PDB:7N8B [DatabaseIdentifier:12142304] PDB:5LYB [DatabaseIdentifier:12142306] PDB:4U56 [DatabaseIdentifier:12142334] PDB:4V8Y [DatabaseIdentifier:12142357] PDB:3J77 [DatabaseIdentifier:12142307] PDB:4U4Y [DatabaseIdentifier:12140532] PDB:8YLD [DatabaseIdentifier:12142337] PDB:7ZPQ [DatabaseIdentifier:12142323] PDB:6T83 [DatabaseIdentifier:12142326] PDB:6T7T [DatabaseIdentifier:12142297] PDB:8P85 [DatabaseIdentifier:12142358] PDB:8EVS [DatabaseIdentifier:12142302] PDB:5JUO [DatabaseIdentifier:12142318] PDB:6S47 [DatabaseIdentifier:12141518] PDB:6RBD [DatabaseIdentifier:12142295] PDB:5JUU [DatabaseIdentifier:12142294] PDB:5JUS [DatabaseIdentifier:12142331] PDB:5I4L [DatabaseIdentifier:12142308] PDB:4U4Z [DatabaseIdentifier:12142348] PDB:3J6Y [DatabaseIdentifier:12142303] PDB:4U55 [DatabaseIdentifier:12140535] PDB:8Z71 [DatabaseIdentifier:12142341] PDB:7MPJ [DatabaseIdentifier:12142296] PDB:5JUT [DatabaseIdentifier:12142301] PDB:5NDW [DatabaseIdentifier:12142305] PDB:4U4U
databaseName	UniProt
dbId	99457
description	recommendedName: fullName evidence="7"Small ribosomal subunit protein eS19A alternativeName: fullName evidence="8"40S ribosomal protein S19-A alternativeName: RP55A alternativeName: S16a alternativeName: YP45 alternativeName: YS16A
displayName	UniProt:P07280 RPS19A
geneName	RPS19A RP55A RPS16AA YOL121C
identifier	P07280
isSequenceChanged	false
keyword	3D-structure Cytoplasm Direct protein sequencing Reference proteome Ribonucleoprotein Ribosomal protein Ribosome biogenesis
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPS19A
otherIdentifier	854028 GO:0000028 GO:0000054 GO:0002181 GO:0003723 GO:0003735 GO:0005198 GO:0005575 GO:0005737 GO:0005829 GO:0005840 GO:0006407 GO:0006412 GO:0008150 GO:0022627 GO:0042254 GO:0042274 GO:0051169 GO:1990904
physicalEntity	[EntityWithAccessionedSequence:R-SCE-72343] RPS19A [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-9633148] RPS19A [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-6798710] RPS19A [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11364044] BioGPS Gene:854028 RPS19A [ReferenceDNASequence:12701786] UCSC:P07280 RPS19A [ReferenceDNASequence:11902722] KEGG:sce:YOL121C RPS19A [ReferenceDNASequence:11993833] Monarch:854028 RPS19A [ReferenceDNASequence:12077926] NCBI Gene:854028 RPS19A
referenceTranscript	[ReferenceRNASequence:12606973] RefSeq:NM_001183375.1 RPS19A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RS19A_YEAST D6W1U7
sequenceLength	144
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P07280
url	http://purl.uniprot.org/uniprot/P07280

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-SCE-72343] RPS19A [cytosol] [EntityWithAccessionedSequence:R-SCE-9633148] RPS19A [cytosol] [EntityWithAccessionedSequence:R-SCE-6798710] RPS19A [nucleoplasm]
(interactor)	[UndirectedInteraction:11151259] UniProt:Q07381 <-> UniProt:P07280 (IntAct)

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