Reactome | UniProt:P07203 GPX1

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UniProt:P07203 GPX1 Show undefined attributes

chain	chain:1-203
checksum	5DB11579C66FE8E5
comment	FUNCTION Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:11115402, PubMed:36608588). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway (PubMed:11115402).CATALYTIC ACTIVITY 2 glutathione + H2O2 = glutathione disulfide + 2 H2OCATALYTIC ACTIVITY a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2OCATALYTIC ACTIVITY tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2OCATALYTIC ACTIVITY cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2OCATALYTIC ACTIVITY (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2OCATALYTIC ACTIVITY (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2OCATALYTIC ACTIVITY (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2OCATALYTIC ACTIVITY (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2OCATALYTIC ACTIVITY (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2OCATALYTIC ACTIVITY (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2OCATALYTIC ACTIVITY (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2OCATALYTIC ACTIVITY (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2OCATALYTIC ACTIVITY (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2OCATALYTIC ACTIVITY (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2OCATALYTIC ACTIVITY (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2OSUBUNIT Homotetramer. Interacts with MIEN1.INTERACTION Expressed in platelets (at protein level).PTM During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.SIMILARITY Belongs to the glutathione peroxidase family.ONLINE INFORMATION Glutathione peroxidase entry
crossReference	[DatabaseIdentifier:12422644] RefSeq:NP_958799.1 [DatabaseIdentifier:12422643] RefSeq:NP_000572.2 [DatabaseIdentifier:12288494] Pharos - Targets:P07203 [DatabaseIdentifier:12249757] PRO:P07203 [DatabaseIdentifier:12204202] PDB:2F8A [DatabaseIdentifier:12128273] OpenTargets:ENSG00000233276 [DatabaseIdentifier:11851108] IntEnz:1.11.1.12 [DatabaseIdentifier:11850292] IntEnz:1.11.1.9 [DatabaseIdentifier:11843658] HPA:ENSG00000233276-GPX1 [DatabaseIdentifier:11831906] HMDB Protein:HMDBP00828 [DatabaseIdentifier:11806605] GlyGen:P07203 [DatabaseIdentifier:11790654] GeneCards:GPX1 [DatabaseIdentifier:11728724] ENSEMBL:ENST00000703797 [DatabaseIdentifier:11728725] ENSEMBL:ENST00000419349 [DatabaseIdentifier:11728726] ENSEMBL:ENST00000419783 [DatabaseIdentifier:11728727] ENSEMBL:ENST00000704375 [DatabaseIdentifier:11606026] ENSEMBL:ENSP00000391316 [DatabaseIdentifier:11606025] ENSEMBL:ENSP00000515880 [DatabaseIdentifier:11606028] ENSEMBL:ENSP00000407375 [DatabaseIdentifier:11606027] ENSEMBL:ENSP00000515482 [DatabaseIdentifier:11497329] ENSEMBL:ENSG00000233276
databaseName	UniProt
dbId	55998
description	recommendedName: fullName evidence="19"Glutathione peroxidase 1 shortName evidence="17"GPx-1 shortName: GSHPx-1 ecNumber evidence="6 14"1.11.1.9 alternativeName: Cellular glutathione peroxidase alternativeName: fullName evidence="18"Phospholipid-hydroperoxide glutathione peroxidase GPX1 ecNumber evidence="6 14"1.11.1.12
displayName	UniProt:P07203 GPX1
geneName	GPX1
identifier	P07203
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Lipid metabolism Mitochondrion Oxidoreductase Peroxidase Phosphoprotein Proteomics identification Reference proteome Selenocysteine
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	GPX1
otherIdentifier	11725346_x_at 11757455_x_at 16954048 200736_PM_s_at 200736_s_at 2674230 2674231 2674232 2674233 2674234 2674235 2674236 2674237 2674238 2674239 2674240 2674241 2876 37033_s_at 4000050 4000052 4000056 4000064 8087405 8180346 A_23_P250671 A_33_P3239849 GE80927 GO:0000302 GO:0001659 GO:0001885 GO:0002862 GO:0003013 GO:0004601 GO:0004602 GO:0005515 GO:0005737 GO:0005739 GO:0005759 GO:0005829 GO:0006325 GO:0006575 GO:0006629 GO:0006641 GO:0006749 GO:0006790 GO:0006915 GO:0006979 GO:0007605 GO:0008631 GO:0009410 GO:0009609 GO:0009611 GO:0009636 GO:0009650 GO:0009725 GO:0009749 GO:0010269 GO:0010332 GO:0014902 GO:0016491 GO:0017124 GO:0019369 GO:0019372 GO:0030154 GO:0032355 GO:0032496 GO:0033194 GO:0033197 GO:0033599 GO:0034599 GO:0035094 GO:0040029 GO:0042311 GO:0042542 GO:0042744 GO:0043403 GO:0043534 GO:0045444 GO:0045445 GO:0045454 GO:0047066 GO:0048144 GO:0048741 GO:0048856 GO:0048870 GO:0050877 GO:0051402 GO:0051450 GO:0051593 GO:0051702 GO:0051897 GO:0060047 GO:0060055 GO:0061136 GO:0071333 GO:0090201 GO:0097413 GO:0098754 GO:0098869 GO:1902042 GO:1902176 GO:1902905 GO:1990782 ILMN_1749662 ILMN_1787412 PH_hs_0028977 PH_hs_0035460 TC03001407.hg Y00433_at g10834975_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-71673] L-selenocysteine residue-GPX1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3322994] L-selenoC49-GPX1 [mitochondrial matrix] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12701185] UCSC:P07203 GPX1 [ReferenceDNASequence:12113057] OMIM:138320 GPX1 [ReferenceDNASequence:12076716] NCBI Gene:2876 GPX1 [ReferenceDNASequence:11992623] Monarch:2876 GPX1 [ReferenceDNASequence:11901643] KEGG:hsa:2876 GPX1 [ReferenceDNASequence:11822315] HGNC:4553 GPX1 [ReferenceDNASequence:11430374] dbSNP Gene:2876 GPX1 [ReferenceDNASequence:11418132] CTD Gene:2876 GPX1 [ReferenceDNASequence:11394312] COSMIC - genes:GPX1 GPX1 [ReferenceDNASequence:11362834] BioGPS Gene:2876 GPX1 [ReferenceDNASequence:ensembl:ENSG00000233276] ENSEMBL:ENSG00000233276 GPX1
referenceTranscript	[ReferenceRNASequence:12604223] RefSeq:NM_000581.3 GPX1 [ReferenceRNASequence:12604222] RefSeq:NM_201397.3 GPX1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GPX1_HUMAN E9PAS1 Q7Z5H1 Q9BW12
sequenceLength	203
species	[Species:48887] Homo sapiens
stId	uniprot:P07203
url	http://purl.uniprot.org/uniprot/P07203

Referrals

(interactor)	[UndirectedInteraction:11148655] UniProt:P13569 <-> UniProt:P07203 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-71673] L-selenocysteine residue-GPX1 [cytosol] [EntityWithAccessionedSequence:R-HSA-3322994] L-selenoC49-GPX1 [mitochondrial matrix]
(referenceSequence)	[ModifiedResidue:71672] L-selenocysteine residue at 49

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