UniProt:P07195 LDHB

chain
  • initiator methionine:1
  • chain:2-334
checksum 3AD605DEED0D54A2
comment
  • FUNCTION Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).CATALYTIC ACTIVITY (S)-lactate + NAD(+) = pyruvate + NADH + H(+)PATHWAY Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.SUBUNIT Homotetramer (PubMed:11276087). Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria (PubMed:33406399).INTERACTION Predominantly expressed in aerobic tissues such as cardiac muscle.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the LDH/MDH superfamily. LDH family.ONLINE INFORMATION Lactate dehydrogenase entryONLINE INFORMATION Another dark horse - Issue 109 of September 2009
crossReference
databaseName UniProt
dbId 58469
description
  • recommendedName: L-lactate dehydrogenase B chain shortName: LDH-B ecNumber evidence="4 8"1.1.1.27 alternativeName: LDH heart subunit shortName evidence="16"LDH-H alternativeName: Renal carcinoma antigen NY-REN-46
displayName UniProt:P07195 LDHB
geneName
  • LDHB
identifier P07195
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • Membrane
  • Mitochondrion
  • Mitochondrion inner membrane
  • NAD
  • Oxidoreductase
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • LDHB
otherIdentifier
  • 11756099_a_at
  • 16762126
  • 201030_PM_x_at
  • 201030_x_at
  • 213564_PM_x_at
  • 213564_x_at
  • 33819_at
  • 3446869
  • 3446870
  • 3446871
  • 3446874
  • 3446875
  • 3446876
  • 3446877
  • 3446878
  • 3446879
  • 3446882
  • 3446884
  • 3446885
  • 3446886
  • 3446887
  • 3446892
  • 3446893
  • 3446894
  • 3446895
  • 3446896
  • 3446897
  • 3446898
  • 3446899
  • 3446908
  • 3446909
  • 3945
  • 4013160
  • 43827_s_at
  • 7961693
  • A_23_P53476
  • A_33_P3231432
  • GE80813
  • GO:0003824
  • GO:0004457
  • GO:0004459
  • GO:0005515
  • GO:0005737
  • GO:0005739
  • GO:0005743
  • GO:0005829
  • GO:0006089
  • GO:0016020
  • GO:0016491
  • GO:0016616
  • GO:0019674
  • GO:0019752
  • GO:0019900
  • GO:0042802
  • GO:0042867
  • GO:0045121
  • GO:0051287
  • GO:0055086
  • GO:0070062
  • GO:1990204
  • HMNXSV003017690
  • HMNXSV003036989
  • HMNXSV003043425
  • Hs.234489.1.A1_3p_a_at
  • ILMN_1728132
  • PH_hs_0029462
  • TC12001298.hg
  • X13794_rna1_at
  • g4557031_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • LDHB_HUMAN
sequenceLength 334
species [Species:48887] Homo sapiens
stId uniprot:P07195
url http://purl.uniprot.org/uniprot/P07195
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