Reactome | UniProt:P07148 FABP1

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UniProt:P07148 FABP1 Show undefined attributes

chain	chain:1-127
checksum	065DCEFB08DAB6B6
comment	FUNCTION Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).INTERACTION Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.SIMILARITY Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
crossReference	[DatabaseIdentifier:12206381] PDB:2LKK [DatabaseIdentifier:12816370] ZINC target:P07148 [DatabaseIdentifier:12424142] RefSeq:NP_001434.1 [DatabaseIdentifier:12288937] Pharos - Targets:P07148 [DatabaseIdentifier:12250345] PRO:P07148 [DatabaseIdentifier:12206353] PDB:7DZE [DatabaseIdentifier:12206350] PDB:7DZG [DatabaseIdentifier:12206364] PDB:2L67 [DatabaseIdentifier:12206355] PDB:7DZK [DatabaseIdentifier:12206386] PDB:7FXO [DatabaseIdentifier:12206380] PDB:7G00 [DatabaseIdentifier:12206360] PDB:3VG5 [DatabaseIdentifier:12206374] PDB:3B2I [DatabaseIdentifier:12206369] PDB:3B2L [DatabaseIdentifier:12206362] PDB:2L68 [DatabaseIdentifier:12206356] PDB:7DZL [DatabaseIdentifier:12206379] PDB:2F73 [DatabaseIdentifier:12206378] PDB:6MP4 [DatabaseIdentifier:11497925] ENSEMBL:ENSG00000163586 [DatabaseIdentifier:11607002] ENSEMBL:ENSP00000295834 [DatabaseIdentifier:11729701] ENSEMBL:ENST00000295834 [DatabaseIdentifier:11779198] Guide to Pharmacology - Targets:2531 [DatabaseIdentifier:11791093] GeneCards:FABP1 [DatabaseIdentifier:11807054] GlyGen:P07148 [DatabaseIdentifier:11844098] HPA:ENSG00000163586-FABP1 [DatabaseIdentifier:12128716] OpenTargets:ENSG00000163586 [DatabaseIdentifier:12206367] PDB:6DO7 [DatabaseIdentifier:12206382] PDB:7FYA [DatabaseIdentifier:12206357] PDB:7DZI [DatabaseIdentifier:12206375] PDB:3B2J [DatabaseIdentifier:12206373] PDB:3B2H [DatabaseIdentifier:12206368] PDB:3B2K [DatabaseIdentifier:12206370] PDB:3VG2 [DatabaseIdentifier:12206385] PDB:7FY8 [DatabaseIdentifier:12206365] PDB:6DO6 [DatabaseIdentifier:12206372] PDB:6DRG [DatabaseIdentifier:12206359] PDB:3VG4 [DatabaseIdentifier:12206363] PDB:3VG7 [DatabaseIdentifier:12206376] PDB:3STM [DatabaseIdentifier:12206383] PDB:7G1X [DatabaseIdentifier:12206352] PDB:7DZH [DatabaseIdentifier:12206371] PDB:3VG3 [DatabaseIdentifier:12206366] PDB:7G0W [DatabaseIdentifier:12206358] PDB:7DZJ [DatabaseIdentifier:12206377] PDB:3STN [DatabaseIdentifier:12206351] PDB:2PY1 [DatabaseIdentifier:12206361] PDB:3VG6 [DatabaseIdentifier:12206384] PDB:3STK [DatabaseIdentifier:12206354] PDB:7DZF
databaseName	UniProt
dbId	54626
description	recommendedName: Fatty acid-binding protein, liver alternativeName: Fatty acid-binding protein 1 alternativeName: Liver-type fatty acid-binding protein shortName: L-FABP
displayName	UniProt:P07148 FABP1
geneName	FABP1 FABPL
identifier	P07148
isSequenceChanged	false
keyword	3D-structure Acetylation Cytoplasm Lipid-binding Phosphoprotein Proteomics identification Reference proteome Transport
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	FABP1
otherIdentifier	11723040_a_at 11723041_s_at 11758878_x_at 16900030 205892_PM_s_at 205892_s_at 2168 2563538 2563539 2563540 2563541 2563542 2563543 2563544 2563545 2563546 2563547 2563548 2563550 2563554 2563555 38586_at 8053654 A_23_P79562 A_33_P3326962 GE81021 GO:0003682 GO:0005504 GO:0005515 GO:0005634 GO:0005654 GO:0005737 GO:0005782 GO:0005829 GO:0008289 GO:0015908 GO:0016209 GO:0070062 GO:0070301 GO:0071456 GO:0098754 GO:0098869 GO:1990748 HMNXSV003007276 HMNXSV003020505 ILMN_1678965 M10050_at PH_hs_0018467 PH_hs_0038783 TC02002069.hg TC02004392.hg g4557576_3p_at g4557576_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-1989743] FABP1 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2026981] FABP1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000163586] ENSEMBL:ENSG00000163586 FABP1 [ReferenceDNASequence:12701499] UCSC:P07148 FABP1 [ReferenceDNASequence:11363459] BioGPS Gene:2168 FABP1 [ReferenceDNASequence:11394379] COSMIC - genes:FABP1 FABP1 [ReferenceDNASequence:11418697] CTD Gene:2168 FABP1 [ReferenceDNASequence:11430444] dbSNP Gene:2168 FABP1 [ReferenceDNASequence:11822759] HGNC:3555 FABP1 [ReferenceDNASequence:11902208] KEGG:hsa:2168 FABP1 [ReferenceDNASequence:11993248] Monarch:2168 FABP1 [ReferenceDNASequence:12077341] NCBI Gene:2168 FABP1 [ReferenceDNASequence:12113450] OMIM:134650 FABP1
referenceTranscript	[ReferenceRNASequence:12605732] RefSeq:NM_001443.3 FABP1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	FABPL_HUMAN
sequenceLength	127
species	[Species:48887] Homo sapiens
stId	uniprot:P07148
url	http://purl.uniprot.org/uniprot/P07148

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-1989743] FABP1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2026981] FABP1 [cytosol]
(interactor)	[UndirectedInteraction:11188379] UniProt:P54764 <-> UniProt:P07148 (IntAct) [UndirectedInteraction:11293545] UniProt:P07148 <-> UniProt:Q96EK6 (IntAct) [UndirectedInteraction:11293549] UniProt:P07148 <-> UniProt:FLNA (IntAct) [UndirectedInteraction:11293551] UniProt:P07148 <-> UniProt:P21333-2 (IntAct)

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