Reactome | UniProt:P07143 CYT1

Schema > ReferenceGeneProduct > Entries

UniProt:P07143 CYT1 Show undefined attributes

chain	transit peptide:1-61 chain:62-309
checksum	6CB7A0813AA06AF5
comment	FUNCTION Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable). Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c (PubMed:18390544).CATALYTIC ACTIVITY a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)COFACTOR Binds 1 heme c group covalently per subunit.SUBUNIT Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10764779, PubMed:10775262, PubMed:30598554, PubMed:30598556). CYT1 interacts with COX5A at the CIII-CIV interface (PubMed:30598554).SUBCELLULAR LOCATION Present with 39900 molecules/cell in log phase SD medium.SIMILARITY Belongs to the cytochrome c family.
crossReference	[DatabaseIdentifier:12424103] RefSeq:NP_014708.1 [DatabaseIdentifier:12250340] PRO:P07143 [DatabaseIdentifier:12168674] PDB:1P84 [DatabaseIdentifier:12149752] PDB:6YMX [DatabaseIdentifier:12168673] PDB:1KYO [DatabaseIdentifier:12168676] PDB:8ZMT [DatabaseIdentifier:12149747] PDB:6GIQ [DatabaseIdentifier:12149755] PDB:6T15 [DatabaseIdentifier:12168677] PDB:4PD4 [DatabaseIdentifier:12168671] PDB:1KB9 [DatabaseIdentifier:12149749] PDB:9BPB [DatabaseIdentifier:12168672] PDB:1EZV [DatabaseIdentifier:12168681] PDB:8YIN [DatabaseIdentifier:12149753] PDB:9ETZ [DatabaseIdentifier:12149750] PDB:8E7S [DatabaseIdentifier:12168682] PDB:8YIO [DatabaseIdentifier:12168678] PDB:3CX5 [DatabaseIdentifier:12168675] PDB:8YHQ [DatabaseIdentifier:12149756] PDB:6HU9 [DatabaseIdentifier:12168680] PDB:3CXH [DatabaseIdentifier:12149754] PDB:6T0B [DatabaseIdentifier:12168679] PDB:2IBZ [DatabaseIdentifier:12149748] PDB:8EC0 [DatabaseIdentifier:12168683] PDB:8YIL [DatabaseIdentifier:11729687] ENSEMBL:YOR065W_mRNA [DatabaseIdentifier:11606988] ENSEMBL:YOR065W [DatabaseIdentifier:11497913] ENSEMBL:YOR065W
databaseName	UniProt
dbId	88550
description	recommendedName: Cytochrome c1, heme protein, mitochondrial ecNumber evidence="6"7.1.1.8 alternativeName: Complex III subunit 4 alternativeName: Complex III subunit IV alternativeName: Cytochrome b-c1 complex subunit 4 alternativeName: Ubiquinol-cytochrome c oxidoreductase cytochrome c1 subunit shortName: Cytochrome c-1
displayName	UniProt:P07143 CYT1
geneName	CYT1 CTC1 YOR065W YOR29-16
identifier	P07143
isSequenceChanged	false
keyword	3D-structure Electron transport Heme Iron Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Reference proteome Respiratory chain Transit peptide Translocase Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
moleculeType	Protein
name	CYT1
otherIdentifier	854231 GO:0003674 GO:0005575 GO:0005739 GO:0005743 GO:0005750 GO:0005758 GO:0005829 GO:0006091 GO:0006122 GO:0006811 GO:0008121 GO:0009055 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022857 GO:0042776 GO:0043167 GO:0045153 GO:0045275 GO:0045333 GO:0046872 GO:0055085 GO:0055086 GO:1902600
physicalEntity	[EntityWithAccessionedSequence:R-SCE-9866129] CYT1 [mitochondrial inner membrane] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252109] CYT1 [mitochondrial intermembrane space] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-1252090] CYT1 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-164277] CYC1 [mitochondrial inner membrane] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12701490] UCSC:P07143 CYT1 [ReferenceDNASequence:12077329] NCBI Gene:854231 CYT1 [ReferenceDNASequence:11993236] Monarch:854231 CYT1 [ReferenceDNASequence:11902200] KEGG:sce:YOR065W CYT1 [ReferenceDNASequence:11363447] BioGPS Gene:854231 CYT1
referenceTranscript	[ReferenceRNASequence:12605693] RefSeq:NM_001183484.1 CYT1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CY1_YEAST D6W2C8
sequenceLength	309
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P07143
url	http://purl.uniprot.org/uniprot/P07143

Referrals

(interactor)

(referenceEntity)