UniProt:P06729 CD2

chain
  • signal peptide:1-24
  • chain:25-351
checksum A03D853C3B618917
comment
  • FUNCTION CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.SUBUNIT Interacts with CD48 (By similarity). Interacts with CD58 (LFA-3) (PubMed:10380930). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (PubMed:9857189). Interacts with FCGR3A; this interaction modulates NK cell activation and cytotoxicity.INTERACTION Expressed in natural killer cells (at protein level).ONLINE INFORMATION CD2 entry
crossReference
databaseName UniProt
dbId 51640
description
  • recommendedName: T-cell surface antigen CD2 alternativeName: Erythrocyte receptor alternativeName: LFA-2 alternativeName: LFA-3 receptor alternativeName: Rosette receptor alternativeName: T-cell surface antigen T11/Leu-5 cdAntigenNameCD2/cdAntigenName
displayName UniProt:P06729 CD2
geneName
  • CD2
  • SRBC
identifier P06729
isSequenceChanged false
keyword
  • 3D-structure
  • Cell adhesion
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Immunoglobulin domain
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • CD2
otherIdentifier
  • 11733736_a_at
  • 16669169
  • 205831_PM_at
  • 205831_at
  • 2353670
  • 2353671
  • 2353672
  • 2353673
  • 2353675
  • 2353676
  • 2353681
  • 2353685
  • 2353686
  • 2353687
  • 2353688
  • 2353689
  • 2353690
  • 2353691
  • 2353692
  • 2353693
  • 40738_at
  • 7904287
  • 914
  • A_14_P112244
  • A_23_P161076
  • A_33_P3278013
  • GE81066
  • GO:0001766
  • GO:0002376
  • GO:0005102
  • GO:0005515
  • GO:0005576
  • GO:0005654
  • GO:0005794
  • GO:0005886
  • GO:0005911
  • GO:0006915
  • GO:0006955
  • GO:0007155
  • GO:0007166
  • GO:0009897
  • GO:0009898
  • GO:0009986
  • GO:0016020
  • GO:0019901
  • GO:0030101
  • GO:0030887
  • GO:0030971
  • GO:0032729
  • GO:0032757
  • GO:0032760
  • GO:0032991
  • GO:0034113
  • GO:0038023
  • GO:0042110
  • GO:0042267
  • GO:0042802
  • GO:0045580
  • GO:0061024
  • GO:0098609
  • HMNXSV003009623
  • HMNXSV003011198
  • ILMN_1695025
  • M16336_s_at
  • PH_hs_0004986
  • TC01001022.hg
  • g4502652_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CD2_HUMAN
  • Q96TE5
sequenceLength 351
species [Species:48887] Homo sapiens
stId uniprot:P06729
url http://purl.uniprot.org/uniprot/P06729
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