UniProt:P06331 IGHV4-34

chain
  • signal peptide:1-26
  • chain:27-123
checksum 7E62E262496B3CBD
comment
  • FUNCTION V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).SUBUNIT Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.SUBCELLULAR LOCATION There are several alleles. The sequence shown is that of IMGT allele IGHV4-34*01.CAUTION For examples of full-length immunoglobulin heavy chains (of different isotypes) see AC P0DOX2, AC P0DOX3, AC P0DOX4, AC P0DOX5 and AC P0DOX6.
crossReference
databaseName UniProt
dbId 56770
description
  • recommendedName: fullName evidence="4 9"Immunoglobulin heavy variable 4-34 alternativeName: fullName evidence="11"Ig heavy chain V-II region ARH-77
displayName UniProt:P06331 IGHV4-34
geneName
  • IGHV4-34
identifier P06331
isSequenceChanged false
keyword
  • Adaptive immunity
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Immunity
  • Immunoglobulin
  • Immunoglobulin domain
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Secreted
  • Signal
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • IGHV4-34
otherIdentifier
  • 11763678_x_at
  • 16797520
  • 211639_3p_x_at
  • 211639_PM_x_at
  • 211639_x_at
  • 35607_at
  • 3582256
  • 3582292
  • 3582322
  • 3582323
  • 3582324
  • 3582325
  • 3582326
  • 3582329
  • 3582359
  • 3582360
  • 3582361
  • 3582478
  • 3582489
  • 3582513
  • GO:0002250
  • GO:0002376
  • GO:0003823
  • GO:0005576
  • GO:0005886
  • GO:0006955
  • GO:0016020
  • GO:0016064
  • GO:0019814
  • ILMN_1655940
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • HV434_HUMAN
  • A0A0A0MS12
  • A0A0G2JP38
sequenceLength 123
species [Species:48887] Homo sapiens
stId uniprot:P06331
url http://purl.uniprot.org/uniprot/P06331
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