UniProt:P06312 IGKV4-1

chain
  • signal peptide:1-20
  • chain:21-121
checksum 9586AD4188D33974
comment
  • FUNCTION V segment of the variable domain of immunoglobulins light chain that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).SUBUNIT Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.SUBCELLULAR LOCATION There are several alleles. The sequence shown is that of IMGT allele IGKV4-1*01.CAUTION For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7.SEQUENCE CAUTION Chimeric DNA corresponding to regions V and J of immunoglobulin kappa light chain.SEQUENCE CAUTION Chimeric DNA corresponding to regions V and J of immunoglobulin kappa light chain.
crossReference
databaseName UniProt
dbId 58365
description
  • recommendedName: fullName evidence="5 10"Immunoglobulin kappa variable 4-1 alternativeName: fullName evidence="12"Ig kappa chain V-IV region B17 alternativeName: fullName evidence="13"Ig kappa chain V-IV region JI alternativeName: fullName evidence="13"Ig kappa chain V-IV region Len alternativeName: fullName evidence="14"Ig kappa chain V-IV region STH
displayName UniProt:P06312 IGKV4-1
geneName
  • IGKV4-1
identifier P06312
isSequenceChanged false
keyword
  • 3D-structure
  • Adaptive immunity
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Immunity
  • Immunoglobulin
  • Immunoglobulin domain
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Secreted
  • Signal
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • IGKV4-1
otherIdentifier
  • 16882710
  • 214777_3p_at
  • 214777_PM_at
  • 214777_at
  • 2493071
  • 2493073
  • 2493074
  • 2493075
  • 2493142
  • 2493144
  • 2493146
  • 2493148
  • 8043423
  • A_32_P157927
  • GO:0002250
  • GO:0002376
  • GO:0003823
  • GO:0005576
  • GO:0005886
  • GO:0006955
  • GO:0016020
  • GO:0019814
  • GO:0072562
  • HMNXSV003031556
  • Hs.248756.0.S1_3p_x_at
  • TC02000550.hg
  • TC02003394.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • KV401_HUMAN
  • P01625
  • P06313
  • P06314
  • P83593
sequenceLength 121
species [Species:48887] Homo sapiens
stId uniprot:P06312
url http://purl.uniprot.org/uniprot/P06312
Cite Us!