UniProt:P06126 CD1A

chain
  • signal peptide:1-16
  • chain:17-327
checksum C575C3C538F0AA29
comment
  • FUNCTION Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.SUBUNIT Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.INTERACTION Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838).TISSUE SPECIFICITY Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.MISCELLANEOUS During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.
crossReference
databaseName UniProt
dbId 51622
description
  • recommendedName: T-cell surface glycoprotein CD1a alternativeName: T-cell surface antigen T6/Leu-6 shortName: hTa1 thymocyte antigen cdAntigenNameCD1a/cdAntigenName
displayName UniProt:P06126 CD1A
geneName
  • CD1A
identifier P06126
isSequenceChanged false
keyword
  • 3D-structure
  • Adaptive immunity
  • Cell membrane
  • Disulfide bond
  • Endosome
  • Glycoprotein
  • Immunity
  • Immunoglobulin domain
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • CD1A
otherIdentifier
  • 11744970_a_at
  • 16672315
  • 210325_PM_at
  • 210325_at
  • 2362189
  • 2362190
  • 2362191
  • 2362192
  • 2362193
  • 2362194
  • 2362195
  • 2362196
  • 2362237
  • 2439293
  • 34926_at
  • 7906339
  • 909
  • A_14_P127974
  • A_23_P402670
  • A_23_P63167
  • GE79908
  • GO:0001916
  • GO:0002250
  • GO:0002376
  • GO:0005515
  • GO:0005615
  • GO:0005768
  • GO:0005886
  • GO:0006955
  • GO:0008289
  • GO:0009897
  • GO:0010008
  • GO:0016020
  • GO:0030883
  • GO:0030884
  • GO:0045121
  • GO:0048006
  • GO:0048007
  • GO:0071723
  • HMNXSV003038515
  • ILMN_1723520
  • M28825_at
  • PH_hs_0000176
  • TC01001338.hg
  • g180035_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CD1A_HUMAN
  • D3DVD7
  • Q13962
  • Q5TDJ8
  • Q9UMM4
  • Q9Y5M5
sequenceLength 327
species [Species:48887] Homo sapiens
stId uniprot:P06126
url http://purl.uniprot.org/uniprot/P06126
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