Reactome | UniProt:P05750 RPS3

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UniProt:P05750 RPS3 Show undefined attributes

chain	initiator methionine:1 chain:2-240
checksum	B85C0DFEB011745F
comment	FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.SUBUNIT Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:22096102, PubMed:9559554).INTERACTION Ubiquitinated at Lys-212 in response to stalled ribosomes (PubMed:28757607, PubMed:28943311, PubMed:30718516, PubMed:30893611, PubMed:31819057). Ubiquitination leads to activation of the No-Go Decay (NGD) pathway and degradation of non-functional 18S rRNA: first monoubiquitinated at Lys-212 by MAG2, followed by formation of 'Lys-63'-linked polyubiquitin chains on monoubiquitin by HEL2 and RSP5 (PubMed:30893611).MASS SPECTROMETRY The measured mass is that of the monomethylated protein.MISCELLANEOUS Present with 146000 molecules/cell in log phase SD medium.SIMILARITY Belongs to the universal ribosomal protein uS3 family.
crossReference	[DatabaseIdentifier:12142322] PDB:9F9S [DatabaseIdentifier:12444076] RefSeq:NP_014221.3 [DatabaseIdentifier:12259803] PRO:P05750 [DatabaseIdentifier:12142416] PDB:4U4R [DatabaseIdentifier:12142400] PDB:5DGV [DatabaseIdentifier:12142383] PDB:8P4V [DatabaseIdentifier:12142410] PDB:4U50 [DatabaseIdentifier:12142380] PDB:7ZRS [DatabaseIdentifier:12142398] PDB:8CDR [DatabaseIdentifier:12142369] PDB:8T3C [DatabaseIdentifier:12142397] PDB:4U3M [DatabaseIdentifier:12139503] PDB:6ZU9 [DatabaseIdentifier:12142370] PDB:8T3D [DatabaseIdentifier:12142412] PDB:5NDG [DatabaseIdentifier:12142377] PDB:8T2Y [DatabaseIdentifier:12142413] PDB:4U4Q [DatabaseIdentifier:12142425] PDB:7ZUX [DatabaseIdentifier:12142353] PDB:8ZHC [DatabaseIdentifier:12142346] PDB:3J78 [DatabaseIdentifier:12142367] PDB:8T3F [DatabaseIdentifier:12142396] PDB:8PNN [DatabaseIdentifier:12142393] PDB:8K2D [DatabaseIdentifier:12142403] PDB:5DGE [DatabaseIdentifier:12142357] PDB:3J77 [DatabaseIdentifier:12142395] PDB:5FCJ [DatabaseIdentifier:12142384] PDB:6Z6J [DatabaseIdentifier:12142401] PDB:8CDL [DatabaseIdentifier:12142352] PDB:8BQD [DatabaseIdentifier:12142404] PDB:5DGF [DatabaseIdentifier:12142361] PDB:8T3B [DatabaseIdentifier:12142351] PDB:8ZHB [DatabaseIdentifier:12142371] PDB:8ZGR [DatabaseIdentifier:12142423] PDB:5ON6 [DatabaseIdentifier:12142385] PDB:8CCS [DatabaseIdentifier:12142424] PDB:5TGM [DatabaseIdentifier:12142355] PDB:6ZVI [DatabaseIdentifier:12142408] PDB:4U4N [DatabaseIdentifier:12142342] PDB:7NRC [DatabaseIdentifier:12142402] PDB:5FCI [DatabaseIdentifier:12142378] PDB:5OBM [DatabaseIdentifier:12142375] PDB:8T2X [DatabaseIdentifier:12142359] PDB:8T3A [DatabaseIdentifier:12142418] PDB:5M1J [DatabaseIdentifier:12142391] PDB:8XU8 [DatabaseIdentifier:12142394] PDB:5TGA [DatabaseIdentifier:12142347] PDB:3J6X [DatabaseIdentifier:12142344] PDB:7MPI [DatabaseIdentifier:12142390] PDB:7A1G [DatabaseIdentifier:12142354] PDB:6GQ1 [DatabaseIdentifier:12142366] PDB:8T3E [DatabaseIdentifier:12142417] PDB:4U53 [DatabaseIdentifier:12142356] PDB:8ZGY [DatabaseIdentifier:12141513] PDB:6FAI [DatabaseIdentifier:12142411] PDB:4U51 [DatabaseIdentifier:12140964] PDB:4V5Z [DatabaseIdentifier:12139511] PDB:8CAH [DatabaseIdentifier:12142422] PDB:4U3U [DatabaseIdentifier:12142414] PDB:4U52 [DatabaseIdentifier:12142388] PDB:6GQV [DatabaseIdentifier:12142372] PDB:8ZH3 [DatabaseIdentifier:12154673] PDB:4BSZ [DatabaseIdentifier:12142415] PDB:7ZW0 [DatabaseIdentifier:12142409] PDB:4U4O [DatabaseIdentifier:12141519] PDB:8CBJ [DatabaseIdentifier:12142368] PDB:6TB3 [DatabaseIdentifier:12142386] PDB:8BQX [DatabaseIdentifier:12142341] PDB:7MPJ [DatabaseIdentifier:12142381] PDB:8T2Z [DatabaseIdentifier:12142426] PDB:7ZUW [DatabaseIdentifier:12142392] PDB:6GQB [DatabaseIdentifier:12152563] PDB:4V4B [DatabaseIdentifier:12142374] PDB:6WOO [DatabaseIdentifier:12142419] PDB:4V6I [DatabaseIdentifier:12142382] PDB:6Z6K [DatabaseIdentifier:12142348] PDB:3J6Y [DatabaseIdentifier:12142343] PDB:7NRD [DatabaseIdentifier:12140536] PDB:8YLR [DatabaseIdentifier:12142345] PDB:6SNT [DatabaseIdentifier:12142407] PDB:6T4Q [DatabaseIdentifier:12142399] PDB:4U3N [DatabaseIdentifier:12140532] PDB:8YLD [DatabaseIdentifier:12141518] PDB:6RBD [DatabaseIdentifier:12142293] PDB:5JUP [DatabaseIdentifier:12142327] PDB:5MEI [DatabaseIdentifier:12142329] PDB:6T7I [DatabaseIdentifier:12142338] PDB:8Z70 [DatabaseIdentifier:12142308] PDB:4U4Z [DatabaseIdentifier:12142312] PDB:6Q8Y [DatabaseIdentifier:12142306] PDB:4U56 [DatabaseIdentifier:12142295] PDB:5JUU [DatabaseIdentifier:12142317] PDB:6WDR [DatabaseIdentifier:12142303] PDB:4U55 [DatabaseIdentifier:12142330] PDB:5TBW [DatabaseIdentifier:12140535] PDB:8Z71 [DatabaseIdentifier:12139514] PDB:6ZCE [DatabaseIdentifier:12142299] PDB:5NDV [DatabaseIdentifier:12142290] PDB:4V7R [DatabaseIdentifier:12142320] PDB:5DAT [DatabaseIdentifier:11507243] ENSEMBL:YNL178W [DatabaseIdentifier:11620872] ENSEMBL:YNL178W [DatabaseIdentifier:11743571] ENSEMBL:YNL178W_mRNA [DatabaseIdentifier:12142335] PDB:7N8B [DatabaseIdentifier:12142297] PDB:8P85 [DatabaseIdentifier:12142305] PDB:4U4U [DatabaseIdentifier:12142333] PDB:8P9A [DatabaseIdentifier:12142315] PDB:4U6F [DatabaseIdentifier:12140531] PDB:7B7D [DatabaseIdentifier:12142336] PDB:4V8Z [DatabaseIdentifier:12142294] PDB:5JUS [DatabaseIdentifier:12142334] PDB:4V8Y [DatabaseIdentifier:12142307] PDB:4U4Y [DatabaseIdentifier:12142298] PDB:5MC6 [DatabaseIdentifier:12142321] PDB:6TNU [DatabaseIdentifier:12142332] PDB:8K82 [DatabaseIdentifier:12142331] PDB:5I4L [DatabaseIdentifier:12142309] PDB:6SV4 [DatabaseIdentifier:12142316] PDB:8BN3 [DatabaseIdentifier:12142296] PDB:5JUT [DatabaseIdentifier:12142291] PDB:6RBE [DatabaseIdentifier:12142300] PDB:6I7O [DatabaseIdentifier:12142310] PDB:4V92 [DatabaseIdentifier:12142304] PDB:5LYB [DatabaseIdentifier:12142313] PDB:5DC3 [DatabaseIdentifier:12142311] PDB:8UT0 [DatabaseIdentifier:12142302] PDB:5JUO [DatabaseIdentifier:12142337] PDB:7ZPQ [DatabaseIdentifier:12142325] PDB:6HHQ [DatabaseIdentifier:12142340] PDB:8T30 [DatabaseIdentifier:12142319] PDB:4V88 [DatabaseIdentifier:12139510] PDB:8CAS [DatabaseIdentifier:12142318] PDB:6S47 [DatabaseIdentifier:12142323] PDB:6T83 [DatabaseIdentifier:12142301] PDB:5NDW [DatabaseIdentifier:12142326] PDB:6T7T [DatabaseIdentifier:12142328] PDB:8UTI
databaseName	UniProt
dbId	100722
description	recommendedName: fullName evidence="15"Small ribosomal subunit protein uS3 alternativeName: fullName evidence="16"40S ribosomal protein S3 alternativeName: fullName evidence="16"RP13 alternativeName: fullName evidence="16"YS3
displayName	UniProt:P05750 RPS3
geneName	RPS3 SUF14 YNL178W N1653
identifier	P05750
isSequenceChanged	false
keyword	3D-structure Cytoplasm Direct protein sequencing Isopeptide bond Methylation Phosphoprotein Reference proteome Ribonucleoprotein Ribosomal protein RNA-binding Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPS3
otherIdentifier	855543 GO:0000054 GO:0000056 GO:0002181 GO:0003723 GO:0003735 GO:0003906 GO:0005198 GO:0005515 GO:0005575 GO:0005634 GO:0005737 GO:0005829 GO:0005840 GO:0006259 GO:0006401 GO:0006407 GO:0006412 GO:0008150 GO:0015935 GO:0019899 GO:0022626 GO:0022627 GO:0030686 GO:0030688 GO:0034236 GO:0051169 GO:0070651 GO:1990145 GO:1990904
physicalEntity	[EntityWithAccessionedSequence:R-SCE-72369] RPS3 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-9633213] RPS3 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-6798714] RPS3 [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11372450] BioGPS Gene:855543 RPS3 [ReferenceDNASequence:12707166] UCSC:P05750 RPS3 [ReferenceDNASequence:11910405] KEGG:sce:YNL178W RPS3 [ReferenceDNASequence:12002239] Monarch:855543 RPS3 [ReferenceDNASequence:12086332] NCBI Gene:855543 RPS3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RS3_YEAST D6W107
sequenceLength	240
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P05750
url	http://purl.uniprot.org/uniprot/P05750

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-SCE-72369] RPS3 [cytosol] [EntityWithAccessionedSequence:R-SCE-9633213] RPS3 [cytosol] [EntityWithAccessionedSequence:R-SCE-6798714] RPS3 [nucleoplasm]
(interactor)	[UndirectedInteraction:11210459] UniProt:P40160 <-> UniProt:P05750 (IntAct) [UndirectedInteraction:11255325] UniProt:P34078 <-> UniProt:P05750 (IntAct) [UndirectedInteraction:11297069] UniProt:P38333 <-> UniProt:P05750 (IntAct)

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