Reactome | UniProt:P05386 RPLP1

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UniProt:P05386 RPLP1 Show undefined attributes

chain	initiator methionine:1 chain:2-114
checksum	4C282AB8DCA079C8
comment	FUNCTION Plays an important role in the elongation step of protein synthesis.SUBUNIT Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.INTERACTION Ubiquitinated at Lys-92 and Lys-93 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).SIMILARITY Belongs to the eukaryotic ribosomal protein P1/P2 family.
crossReference	[DatabaseIdentifier:12349150] RefSeq:NP_000994.1 [DatabaseIdentifier:12349151] RefSeq:NP_998890.1 [DatabaseIdentifier:12294501] Pharos - Targets:P05386 [DatabaseIdentifier:12256898] PRO:P05386 [DatabaseIdentifier:12148697] PDB:4V6X [DatabaseIdentifier:12233999] PDB:2LBF [DatabaseIdentifier:12234000] PDB:4BEH [DatabaseIdentifier:12134337] OpenTargets:ENSG00000137818 [DatabaseIdentifier:11849639] HPA:ENSG00000137818-RPLP1 [DatabaseIdentifier:11812462] GlyGen:P05386 [DatabaseIdentifier:11796674] GeneCards:RPLP1 [DatabaseIdentifier:11681783] ENSEMBL:ENST00000260379 [DatabaseIdentifier:11681784] ENSEMBL:ENST00000357790 [DatabaseIdentifier:11559085] ENSEMBL:ENSP00000346037 [DatabaseIdentifier:11559084] ENSEMBL:ENSP00000350437 [DatabaseIdentifier:11464215] ENSEMBL:ENSG00000137818
databaseName	UniProt
dbId	72397
description	recommendedName: fullName evidence="6"Large ribosomal subunit protein P1 alternativeName: 60S acidic ribosomal protein P1
displayName	UniProt:P05386 RPLP1
geneName	RPLP1 RRP1
identifier	P05386
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Isopeptide bond Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPLP1
otherIdentifier	11715538_s_at 11715539_x_at 11741896_x_at 11744834_x_at 16802553 200763_PM_s_at 200763_s_at 2588504 31956_f_at 31957_r_at 3533389 3599858 3599859 3599860 3599861 3599862 3599863 3599864 3599865 3599866 3599867 3599869 3599870 6176 7984562 8180355 A_23_P37445 A_24_P305747 GE501881 GO:0002181 GO:0003735 GO:0005198 GO:0005515 GO:0005737 GO:0005829 GO:0005840 GO:0005925 GO:0006412 GO:0006414 GO:0022625 GO:0022626 GO:0030295 GO:0043021 GO:0098772 GO:1990904 HMNXSV003020992 ILMN_1689725 ILMN_2247594 ILMN_2386530 M17886_at TC15000639.hg g4506668_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-72398] RPLP1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12680374] UCSC:P05386 RPLP1 [ReferenceDNASequence:12118523] OMIM:180520 RPLP1 [ReferenceDNASequence:12042385] NCBI Gene:6176 RPLP1 [ReferenceDNASequence:11958292] Monarch:6176 RPLP1 [ReferenceDNASequence:11870672] KEGG:hsa:6176 RPLP1 [ReferenceDNASequence:11828384] HGNC:10372 RPLP1 [ReferenceDNASequence:11428029] dbSNP Gene:6176 RPLP1 [ReferenceDNASequence:11425951] CTD Gene:6176 RPLP1 [ReferenceDNASequence:11392264] COSMIC - genes:RPLP1 RPLP1 [ReferenceDNASequence:11392265] COSMIC - genes:RRP1 RPLP1 [ReferenceDNASequence:11328503] BioGPS Gene:6176 RPLP1 [ReferenceDNASequence:ensembl:ENSG00000137818] ENSEMBL:ENSG00000137818 RPLP1
referenceTranscript	[ReferenceRNASequence:12531003] RefSeq:NM_001003.3 RPLP1 [ReferenceRNASequence:12531004] RefSeq:NM_213725.2 RPLP1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RLA1_HUMAN A6NIB2
sequenceLength	114
species	[Species:48887] Homo sapiens
stId	uniprot:P05386
url	http://purl.uniprot.org/uniprot/P05386

Referrals

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(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-72398] RPLP1 [cytosol]

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