Reactome | UniProt:P05160 F13B

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UniProt:P05160 F13B Show undefined attributes

chain	signal peptide:1-20 chain:21-661
checksum	57A2FD2A0E35B812
comment	FUNCTION The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.SUBUNIT Tetramer of two A chains (F13A1) and two B (F13B) chains.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION Factor XIII entry
crossReference	[DatabaseIdentifier:12348650] RefSeq:NP_001985.2 [DatabaseIdentifier:12294302] Pharos - Targets:P05160 [DatabaseIdentifier:12256669] PRO:P05160 [DatabaseIdentifier:12188965] PDB:8CMT [DatabaseIdentifier:12188966] PDB:8CMU [DatabaseIdentifier:12137629] Orphanet:F13B [DatabaseIdentifier:12134137] OpenTargets:ENSG00000143278 [DatabaseIdentifier:11849440] HPA:ENSG00000143278-F13B [DatabaseIdentifier:11812236] GlyGen:P05160 [DatabaseIdentifier:11796472] GeneCards:F13B [DatabaseIdentifier:11681365] ENSEMBL:ENST00000367412 [DatabaseIdentifier:11681366] ENSEMBL:ENST00000709526 [DatabaseIdentifier:11558667] ENSEMBL:ENSP00000517743 [DatabaseIdentifier:11558666] ENSEMBL:ENSP00000356382 [DatabaseIdentifier:11463922] ENSEMBL:ENSG00000143278 [DatabaseIdentifier:11463921] ENSEMBL:ENSG00000291998
databaseName	UniProt
dbId	54562
description	recommendedName: Coagulation factor XIII B chain alternativeName: Fibrin-stabilizing factor B subunit alternativeName: Protein-glutamine gamma-glutamyltransferase B chain alternativeName: Transglutaminase B chain
displayName	UniProt:P05160 F13B
geneName	F13B
identifier	P05160
isSequenceChanged	false
keyword	3D-structure Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Proteomics identification Reference proteome Repeat Secreted Signal Sushi
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	F13B
otherIdentifier	11737202_at 16697528 207810_PM_at 207810_at 2165 2449537 2449538 2449539 2449540 2449542 2449543 2449544 2449545 2449547 2449548 2449549 2449550 2449551 2449552 2449553 2449554 2449555 2449556 34616_at 7923073 A_23_P46549 A_33_P3397496 GE80531 GO:0005576 GO:0005615 GO:0007596 GO:0007599 GO:0051604 GO:0072378 GO:1990234 HMNXSV003048388 ILMN_1735489 M64554_rna1_at PH_hs_0025436 TC01003661.hg X51823_s_at g9961356_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-140605] F13B [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12680256] UCSC:P05160 F13B [ReferenceDNASequence:12118329] OMIM:134580 F13B [ReferenceDNASequence:12042118] NCBI Gene:2165 F13B [ReferenceDNASequence:11958025] Monarch:2165 F13B [ReferenceDNASequence:11870417] KEGG:hsa:2165 F13B [ReferenceDNASequence:11828181] HGNC:3534 F13B [ReferenceDNASequence:11428015] dbSNP Gene:2165 F13B [ReferenceDNASequence:11425706] CTD Gene:2165 F13B [ReferenceDNASequence:11392250] COSMIC - genes:F13B F13B [ReferenceDNASequence:11328236] BioGPS Gene:2165 F13B [ReferenceDNASequence:ensembl:ENSG00000143278] ENSEMBL:ENSG00000143278 F13B
referenceTranscript	[ReferenceRNASequence:12530502] RefSeq:NM_001994.3 F13B
schemaClass	ReferenceGeneProduct
secondaryIdentifier	F13B_HUMAN A8K3E5 Q5VYL5
sequenceLength	661
species	[Species:48887] Homo sapiens
stId	uniprot:P05160
url	http://purl.uniprot.org/uniprot/P05160

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-140605] F13B [extracellular region]