Reactome | UniProt:P04746 AMY2A

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UniProt:P04746 AMY2A Show undefined attributes

chain	signal peptide:1-15 chain:16-511
checksum	A77B1A34EACB3C2A
comment	CATALYTIC ACTIVITY Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.COFACTOR Binds 1 Ca(2+) ion per subunit.COFACTOR Binds 1 Cl(-) ion per subunit.SUBUNIT Monomer. Binds to the sea anemone inhibitor helianthamide (PubMed:27066537).SUBCELLULAR LOCATION Detected in pancreas (at protein level).SIMILARITY Belongs to the glycosyl hydrolase 13 family.ONLINE INFORMATION Amylase entry
crossReference	[DatabaseIdentifier:12163858] PDB:3IJ9 [DatabaseIdentifier:12816952] ZINC target:P04746 [DatabaseIdentifier:12813536] ZINC - Substances:AMYP_HUMAN [DatabaseIdentifier:12314562] RefSeq:XP_047274041.1 [DatabaseIdentifier:12314561] RefSeq:NP_000690.1 [DatabaseIdentifier:12283097] Pharos - Targets:P04746 [DatabaseIdentifier:12241356] PRO:P04746 [DatabaseIdentifier:12163888] PDB:1XH0 [DatabaseIdentifier:12163892] PDB:3BAX [DatabaseIdentifier:12163884] PDB:3OLG [DatabaseIdentifier:12163887] PDB:6OBX [DatabaseIdentifier:12163893] PDB:3BAY [DatabaseIdentifier:12163883] PDB:3OLE [DatabaseIdentifier:12163885] PDB:5KEZ [DatabaseIdentifier:12163890] PDB:4X9Y [DatabaseIdentifier:12163886] PDB:5TD4 [DatabaseIdentifier:12163891] PDB:3BAW [DatabaseIdentifier:12163889] PDB:1KB3 [DatabaseIdentifier:12163871] PDB:1XD0 [DatabaseIdentifier:12163856] PDB:3IJ8 [DatabaseIdentifier:12163851] PDB:1U30 [DatabaseIdentifier:12163860] PDB:3BAJ [DatabaseIdentifier:12163853] PDB:3IJ7 [DatabaseIdentifier:12163865] PDB:1BSI [DatabaseIdentifier:12163859] PDB:1KGU [DatabaseIdentifier:12163868] PDB:3OLI [DatabaseIdentifier:12163867] PDB:5E0F [DatabaseIdentifier:12163877] PDB:1XCW [DatabaseIdentifier:12163875] PDB:1XCX [DatabaseIdentifier:12163861] PDB:3BAK [DatabaseIdentifier:12163843] PDB:5VA9 [DatabaseIdentifier:11447158] ENSEMBL:ENSG00000243480 [DatabaseIdentifier:11534904] ENSEMBL:ENSP00000397582 [DatabaseIdentifier:11657603] ENSEMBL:ENST00000414303 [DatabaseIdentifier:11780086] Guide to Pharmacology - Targets:2596 [DatabaseIdentifier:11785186] GeneCards:AMY2A [DatabaseIdentifier:11800703] GlyGen:P04746 [DatabaseIdentifier:11833365] HMDB Protein:HMDBP02084 [DatabaseIdentifier:11838270] HPA:ENSG00000243480-AMY2A [DatabaseIdentifier:12122777] OpenTargets:ENSG00000243480 [DatabaseIdentifier:12163873] PDB:1XH2 [DatabaseIdentifier:12163876] PDB:4GQQ [DatabaseIdentifier:12163882] PDB:3CPU [DatabaseIdentifier:12163847] PDB:1CPU [DatabaseIdentifier:12163848] PDB:2QMK [DatabaseIdentifier:12163852] PDB:5U3A [DatabaseIdentifier:12163874] PDB:1XH1 [DatabaseIdentifier:12163866] PDB:1HNY [DatabaseIdentifier:12163845] PDB:1KBK [DatabaseIdentifier:12163849] PDB:2QV4 [DatabaseIdentifier:12163872] PDB:4W93 [DatabaseIdentifier:12163862] PDB:5EMY [DatabaseIdentifier:12163844] PDB:2CPU [DatabaseIdentifier:12163878] PDB:3OLD [DatabaseIdentifier:12163846] PDB:6OCN [DatabaseIdentifier:12163880] PDB:1KBB [DatabaseIdentifier:12163863] PDB:1B2Y [DatabaseIdentifier:12163850] PDB:1U33 [DatabaseIdentifier:12163879] PDB:4GQR [DatabaseIdentifier:12163854] PDB:1KGX [DatabaseIdentifier:12163869] PDB:6Z8L [DatabaseIdentifier:12163881] PDB:1XGZ [DatabaseIdentifier:12163857] PDB:1KGW [DatabaseIdentifier:12163855] PDB:1U2Y [DatabaseIdentifier:12163864] PDB:3BAI [DatabaseIdentifier:12163870] PDB:1XD1
databaseName	UniProt
dbId	49964
description	recommendedName: Pancreatic alpha-amylase shortName: PA ecNumber evidence="1 2 3 4"3.2.1.1 alternativeName: 1,4-alpha-D-glucan glucanohydrolase
displayName	UniProt:P04746 AMY2A
geneName	AMY2A
identifier	P04746
isSequenceChanged	false
keyword	3D-structure Alternative splicing Calcium Carbohydrate metabolism Chloride Disulfide bond Glycoprotein Glycosidase Hydrolase Metal-binding Proteomics identification Pyrrolidone carboxylic acid Reference proteome Secreted Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	AMY2A
otherIdentifier	11715490_s_at 11744433_x_at 11758637_x_at 16667850 16667881 208498_PM_s_at 208498_s_at 2349418 2349419 2349421 2349423 2349424 2349426 2349427 2349429 2349432 2349435 2349436 2349456 2349457 2349458 2349459 2349460 2349461 2349463 2349464 2349465 2349466 2349467 2349469 2349470 2349471 2349478 2349494 2349495 2349496 2349497 2349498 2349499 2349501 2349504 2349507 2349508 2349511 2349513 2349514 2349519 2349523 2349524 2349530 2349532 2349534 2349536 2349550 2349551 2349552 2349553 2349554 2349555 2349558 2349560 2349563 2349566 2349567 2349570 2425962 2425963 2425966 2425969 2425970 2425972 2425975 2425977 2425979 2425980 2425981 2425982 2425983 2425984 279 36680_at 7903414 7903425 7903440 7918134 89031_at A_14_P130443 D90097_at GO:0003824 GO:0004556 GO:0005509 GO:0005576 GO:0005615 GO:0005975 GO:0016052 GO:0016160 GO:0016787 GO:0016798 GO:0031404 GO:0043169 GO:0044245 GO:0046872 GO:0070062 HMNXSV003008426 ILMN_1719031 ILMN_1751102 ILMN_1801303 ILMN_2094262 ILMN_2131123 PH_hs_0032565 TC01000918.hg TC01000920.hg g4757749_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9922553] AMY2A [secretory granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-189041] AMY2A [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000243480] ENSEMBL:ENSG00000243480 AMY2A [ReferenceDNASequence:12671275] UCSC:P04746 AMY2A [ReferenceDNASequence:11312733] BioGPS Gene:279 AMY2A [ReferenceDNASequence:11391264] COSMIC - genes:AMY2A AMY2A [ReferenceDNASequence:11409529] CTD Gene:279 AMY2A [ReferenceDNASequence:11426869] dbSNP Gene:279 AMY2A [ReferenceDNASequence:11816810] HGNC:477 AMY2A [ReferenceDNASequence:11856300] KEGG:hsa:279 AMY2A [ReferenceDNASequence:11942522] Monarch:279 AMY2A [ReferenceDNASequence:12026615] NCBI Gene:279 AMY2A [ReferenceDNASequence:12108361] OMIM:104650 AMY2A
referenceTranscript	[ReferenceRNASequence:12496635] RefSeq:NM_000699.4 AMY2A [ReferenceRNASequence:12496634] RefSeq:XM_047418085.1 AMY2A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	AMYP_HUMAN B9EJG1 Q9UBH3
sequenceLength	511
species	[Species:48887] Homo sapiens
stId	uniprot:P04746
url	http://purl.uniprot.org/uniprot/P04746

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