Reactome | UniProt:P04412

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
crossReference	[DatabaseIdentifier:11445245] ENSEMBL:FBgn0003731 [DatabaseIdentifier:12310796] RefSeq:NP_476759.1 [DatabaseIdentifier:12239354] PRO:P04412 [DatabaseIdentifier:12154577] PDB:3LTF [DatabaseIdentifier:12154578] PDB:3LTG [DatabaseIdentifier:12154576] PDB:3I2T [DatabaseIdentifier:11850084] IntEnz:2.7.10.1 [DatabaseIdentifier:11799445] GlyGen:P04412 [DatabaseIdentifier:11774842] FlyBase:FBgn0003731 [DatabaseIdentifier:11654704] ENSEMBL:FBtr0071654 [DatabaseIdentifier:11532005] ENSEMBL:FBpp0071571
databaseName	UniProt
dbId	10840709
displayName	UniProt:P04412
identifier	P04412
moleculeType	Protein
otherIdentifier	142966_at 151735_at 1633948_a_at 37455 GO:0000122 GO:0000166 GO:0001654 GO:0001742 GO:0001751 GO:0002009 GO:0003013 GO:0003015 GO:0003824 GO:0004672 GO:0004713 GO:0004714 GO:0005006 GO:0005515 GO:0005524 GO:0005886 GO:0006355 GO:0006468 GO:0007163 GO:0007169 GO:0007173 GO:0007298 GO:0007309 GO:0007367 GO:0007390 GO:0007391 GO:0007395 GO:0007422 GO:0007426 GO:0007431 GO:0007443 GO:0007444 GO:0007455 GO:0007472 GO:0007474 GO:0007476 GO:0007477 GO:0007479 GO:0007482 GO:0008071 GO:0008284 GO:0008340 GO:0008355 GO:0008406 GO:0008586 GO:0009653 GO:0009792 GO:0009880 GO:0009925 GO:0009966 GO:0010628 GO:0010629 GO:0010646 GO:0016020 GO:0016301 GO:0016318 GO:0016324 GO:0016330 GO:0016333 GO:0016740 GO:0022008 GO:0023051 GO:0030031 GO:0030154 GO:0030182 GO:0030381 GO:0030718 GO:0035088 GO:0035149 GO:0035159 GO:0035160 GO:0035225 GO:0035230 GO:0035277 GO:0035309 GO:0035310 GO:0038127 GO:0042127 GO:0042327 GO:0042675 GO:0043066 GO:0043235 GO:0043410 GO:0043703 GO:0045198 GO:0045199 GO:0045465 GO:0045572 GO:0045944 GO:0046530 GO:0046673 GO:0046843 GO:0046872 GO:0048149 GO:0048513 GO:0048546 GO:0048749 GO:0048856 GO:0048865 GO:0048870 GO:0050679 GO:0050877 GO:0051781 GO:0061331 GO:0070374 GO:0090303 GO:0140096 GO:1903688 GO:2000134 GO:2001234
physicalEntity	[EntityWithAccessionedSequence:R-DME-8869138] phospho-p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1254405] phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1254387] phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1252010] phospho-ERBB4jmAcyt2s80 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1252017] phospho-ERBB4jmAcyt1s80 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1251964] phospho-ERBB4jmAcyt1s80 [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1251987] phospho-ERBB4jmAcyt2s80 [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1251984] phospho-ERBB4jmAcyt2m80 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1252004] phospho-ERBB4jmAcyt1m80 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-8864084] phospho-p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-8864090] phospho-p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-180287] phospho-p-4Y-EGFR [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-8863841] phospho-p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-8864019] phospho-p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-8863836] phospho-p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-372889] ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-372885] ERBB3-1 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1810438] phospho-p-Y877-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-8864079] phospho-p-7Y,Y1112-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-179803] phospho-p-6Y-EGFR [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-8864081] phospho-p-6Y,Y1112-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1250313] phospho-p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1250319] phospho-p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1248698] phospho-p-7Y-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1963569] phospho-p-6Y-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1248742] phospho-p-10Y-ERBB3-1 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1810446] phospho-p-Y,Y877-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1678589] phospho-p-Y-ERBB2 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1233237] ERBB4 JM-A CYT-2 isoform [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1233232] ERBB4 JM-B CYT-1 isoform [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1227940] ERBB4 JM-A CYT-1 isoform [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-1250307] phospho-p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-179837] EGFR [plasma membrane] - Drosophila melanogaster
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12670218] UCSC:P04412 [ReferenceDNASequence:12024795] NCBI Gene:37455 [ReferenceDNASequence:11940702] Monarch:37455 [ReferenceDNASequence:11854598] KEGG:dme:Dmel_CG10079 [ReferenceDNASequence:11310913] BioGPS Gene:37455 [ReferenceDNASequence:ensembl:FBgn0003731] ENSEMBL:FBgn0003731 [ReferenceDNASequence:flybase:FBgn0003731] FlyBase:FBgn0003731
referenceTranscript	[ReferenceRNASequence:12492874] RefSeq:NM_057411.4
schemaClass	ReferenceGeneProduct
species	[Species:56210] Drosophila melanogaster
stId	uniprot:P04412
url	http://purl.uniprot.org/uniprot/P04412

(referenceEntity)	[EntityWithAccessionedSequence:R-DME-8869138] phospho-p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] [EntityWithAccessionedSequence:R-DME-1254405] phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] [EntityWithAccessionedSequence:R-DME-1254387] phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] [EntityWithAccessionedSequence:R-DME-1252010] phospho-ERBB4jmAcyt2s80 [nucleoplasm] [EntityWithAccessionedSequence:R-DME-1252017] phospho-ERBB4jmAcyt1s80 [nucleoplasm] [EntityWithAccessionedSequence:R-DME-1251964] phospho-ERBB4jmAcyt1s80 [cytosol] [EntityWithAccessionedSequence:R-DME-1251987] phospho-ERBB4jmAcyt2s80 [cytosol] [EntityWithAccessionedSequence:R-DME-1251984] phospho-ERBB4jmAcyt2m80 [plasma membrane] [EntityWithAccessionedSequence:R-DME-1252004] phospho-ERBB4jmAcyt1m80 [plasma membrane] [EntityWithAccessionedSequence:R-DME-8864084] phospho-p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-8864090] phospho-p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-180287] phospho-p-4Y-EGFR [plasma membrane] [EntityWithAccessionedSequence:R-DME-8863841] phospho-p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-8864019] phospho-p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] [EntityWithAccessionedSequence:R-DME-8863836] phospho-p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-372889] ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-372885] ERBB3-1 [plasma membrane] [EntityWithAccessionedSequence:R-DME-1810438] phospho-p-Y877-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-8864079] phospho-p-7Y,Y1112-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-179803] phospho-p-6Y-EGFR [plasma membrane] [EntityWithAccessionedSequence:R-DME-8864081] phospho-p-6Y,Y1112-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-1250313] phospho-p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform [plasma membrane] [EntityWithAccessionedSequence:R-DME-1250319] phospho-p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform [plasma membrane] [EntityWithAccessionedSequence:R-DME-1248698] phospho-p-7Y-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-1963569] phospho-p-6Y-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-1248742] phospho-p-10Y-ERBB3-1 [plasma membrane] [EntityWithAccessionedSequence:R-DME-1810446] phospho-p-Y,Y877-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-1678589] phospho-p-Y-ERBB2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-1233237] ERBB4 JM-A CYT-2 isoform [plasma membrane] [EntityWithAccessionedSequence:R-DME-1233232] ERBB4 JM-B CYT-1 isoform [plasma membrane] [EntityWithAccessionedSequence:R-DME-1227940] ERBB4 JM-A CYT-1 isoform [plasma membrane] [EntityWithAccessionedSequence:R-DME-1250307] phospho-p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform [plasma membrane] [EntityWithAccessionedSequence:R-DME-179837] EGFR [plasma membrane]
(referenceSequence)	[ModifiedResidue:10861269] O4'-phospho-L-tyrosine at 1248 (in Homo sapiens) [ModifiedResidue:10861268] O4'-phospho-L-tyrosine at 1221 (in Homo sapiens) [ModifiedResidue:10861255] O4'-phospho-L-tyrosine at 877 (in Homo sapiens) [ModifiedResidue:10861265] O4'-phospho-L-tyrosine at 1112 (in Homo sapiens) [ModifiedResidue:10861264] O4'-phospho-L-tyrosine at 1023 (in Homo sapiens) [ModifiedResidue:10861267] O4'-phospho-L-tyrosine at 1196 (in Homo sapiens) [ModifiedResidue:10861266] O4'-phospho-L-tyrosine at 1139 (in Homo sapiens) [ModifiedResidue:10861240] O4'-phospho-L-tyrosine at 1222 (in Homo sapiens) [ModifiedResidue:10840749] O4'-phospho-L-tyrosine at 1110 (in Homo sapiens) [ModifiedResidue:10840748] O4'-phospho-L-tyrosine at 1092 (in Homo sapiens) [ModifiedResidue:10840751] O4'-phospho-L-tyrosine at 1197 (in Homo sapiens) [ModifiedResidue:10840750] O4'-phospho-L-tyrosine at 1172 (in Homo sapiens) [ModifiedResidue:10840747] O4'-phospho-L-tyrosine at 1069 (in Homo sapiens) [ModifiedResidue:10840746] O4'-phospho-L-tyrosine at 1016 (in Homo sapiens) [ModifiedResidue:10861289] O4'-phospho-L-tyrosine at 1178 (in Homo sapiens) [ModifiedResidue:10861288] O4'-phospho-L-tyrosine at 1046 (in Homo sapiens) [ModifiedResidue:10861290] O4'-phospho-L-tyrosine at 1232 (in Homo sapiens) [ModifiedResidue:10861285] O4'-phospho-L-tyrosine at 1242 (in Homo sapiens) [ModifiedResidue:10861284] O4'-phospho-L-tyrosine at 1188 (in Homo sapiens) [ModifiedResidue:10861283] O4'-phospho-L-tyrosine at 1056 (in Homo sapiens) [ModifiedResidue:10861237] O4'-phospho-L-tyrosine at 1328 (in Homo sapiens) [ModifiedResidue:10861239] O4'-phospho-L-tyrosine at 1199 (in Homo sapiens) [ModifiedResidue:10861238] O4'-phospho-L-tyrosine at 1054 (in Homo sapiens) [ModifiedResidue:10861245] O4'-phospho-L-tyrosine at 1289 (in Homo sapiens) [ModifiedResidue:10861244] O4'-phospho-L-tyrosine at 1276 (in Homo sapiens) [ModifiedResidue:10861241] O4'-phospho-L-tyrosine at 1224 (in Homo sapiens) [ModifiedResidue:10861243] O4'-phospho-L-tyrosine at 1262 (in Homo sapiens) [ModifiedResidue:10861242] O4'-phospho-L-tyrosine at 1260 (in Homo sapiens) [ModifiedResidue:10861250] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:10861274] O4'-phospho-L-tyrosine at 1226 (in Homo sapiens)
(interactor)	[UndirectedInteraction:11245697] UniProt:P04412 <-> UniProt:O46034 (IntAct) [UndirectedInteraction:11245693] UniProt:P04412 <-> UniProt:Q01083 (IntAct)

UniProt:P04412 Show undefined attributes

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