Reactome | UniProt:P04085-2 PDGFA

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UniProt:P04085-2 PDGFA Show undefined attributes

chain	signal peptide:1-20 propeptide:21-86 chain:87-211
checksum	48633DDE558EFA43
comment	FUNCTION Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).SUBUNIT Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.INTERACTION Released by platelets upon wounding.ALTERNATIVE PRODUCTS The long form contains a basic insert which acts as a cell retention signal.SIMILARITY Belongs to the PDGF/VEGF growth factor family.
crossReference	[DatabaseIdentifier:12816251] ZINC target:P04085 [DatabaseIdentifier:12812865] ZINC - Substances:PDGFA_HUMAN [DatabaseIdentifier:12808511] ZINC - Predictions - Purchasable:PDGFA_HUMAN [DatabaseIdentifier:12390849] RefSeq:NP_002598.4 [DatabaseIdentifier:12390846] RefSeq:NP_001382295.1 [DatabaseIdentifier:12390847] RefSeq:XP_054214342.1 [DatabaseIdentifier:12390848] RefSeq:XP_047276413.1 [DatabaseIdentifier:12390850] RefSeq:NP_148983.1 [DatabaseIdentifier:12293068] Pharos - Targets:P04085 [DatabaseIdentifier:12276163] PRO:P04085 [DatabaseIdentifier:12228025] PDB:3MJK [DatabaseIdentifier:12132901] OpenTargets:ENSG00000197461 [DatabaseIdentifier:11848213] HPA:ENSG00000197461-PDGFA [DatabaseIdentifier:11811070] GlyGen:P04085 [DatabaseIdentifier:11795246] GeneCards:PDGFA [DatabaseIdentifier:11707220] ENSEMBL:ENST00000402802 [DatabaseIdentifier:11707221] ENSEMBL:ENST00000354513 [DatabaseIdentifier:11584522] ENSEMBL:ENSP00000383889 [DatabaseIdentifier:11584521] ENSEMBL:ENSP00000346508 [DatabaseIdentifier:11482797] ENSEMBL:ENSG00000197461
databaseName	UniProt
dbId	151910
description	recommendedName: Platelet-derived growth factor subunit A shortName: PDGF subunit A alternativeName: PDGF-1 alternativeName: Platelet-derived growth factor A chain alternativeName: Platelet-derived growth factor alpha polypeptide
displayName	UniProt:P04085-2 PDGFA
geneName	PDGFA PDGF1
identifier	P04085
isSequenceChanged	false
isoformParent	[ReferenceGeneProduct:uniprot:P04085] UniProt:P04085 PDGFA
keyword	3D-structure Alternative splicing Cleavage on pair of basic residues Developmental protein Disulfide bond Glycoprotein Growth factor Mitogen Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	PDGFA
physicalEntity	[EntityWithAccessionedSequence:R-HSA-381916] PDGFA-2 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8865269] N-ter PDGFA-2 fragment [Golgi lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-380742] PDGFA-2 [Golgi membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-380739] PDGFA-2 [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12694398] UCSC:P04085 PDGFA [ReferenceDNASequence:12117207] OMIM:173430 PDGFA [ReferenceDNASequence:12062136] NCBI Gene:5154 PDGFA [ReferenceDNASequence:11978043] Monarch:5154 PDGFA [ReferenceDNASequence:11888227] KEGG:hsa:5154 PDGFA [ReferenceDNASequence:11826944] HGNC:8799 PDGFA [ReferenceDNASequence:11429257] dbSNP Gene:5154 PDGFA [ReferenceDNASequence:11424170] CTD Gene:5154 PDGFA [ReferenceDNASequence:11393318] COSMIC - genes:PDGFA PDGFA [ReferenceDNASequence:11348254] BioGPS Gene:5154 PDGFA [ReferenceDNASequence:ensembl:ENSG00000197461] ENSEMBL:ENSG00000197461 PDGFA
referenceTranscript	[ReferenceRNASequence:12572599] RefSeq:NM_002607.5 PDGFA [ReferenceRNASequence:12572602] RefSeq:XM_054358367.1 PDGFA [ReferenceRNASequence:12572600] RefSeq:XM_047420457.1 PDGFA [ReferenceRNASequence:12572603] RefSeq:NM_033023.5 PDGFA [ReferenceRNASequence:12572601] RefSeq:NM_001395366.1 PDGFA
schemaClass	ReferenceIsoform
secondaryIdentifier	PDGFA_HUMAN B5BU73
sequenceLength	211
species	[Species:48887] Homo sapiens
stId	uniprot:P04085-2
url	http://purl.uniprot.org/uniprot/P04085-2
variantIdentifier	P04085-2

Referrals

(interactor)	[UndirectedInteraction:11223249] UniProt:P04085-2 <-> UniProt:Q99750 (IntAct) [UndirectedInteraction:11223247] UniProt:P04085-2 <-> UniProt:O95983-2 (IntAct) [UndirectedInteraction:11223245] UniProt:P04085-2 <-> UniProt:Q12797-6 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-381916] PDGFA-2 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8865269] N-ter PDGFA-2 fragment [Golgi lumen] [EntityWithAccessionedSequence:R-HSA-380742] PDGFA-2 [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-380739] PDGFA-2 [extracellular region]

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