UniProt:P03923 MT-ND6

chain
  • chain:1-174
checksum E50CD9F3FAFC600D
comment
  • FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:14595656, PubMed:8644732). Essential for the catalytic activity and assembly of complex I (PubMed:14595656, PubMed:8644732).CATALYTIC ACTIVITY a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)SUBUNIT Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I subunit 6 family.
crossReference
databaseName UniProt
dbId 60570
description
  • recommendedName: NADH-ubiquinone oxidoreductase chain 6 ecNumber evidence="7 12"7.1.1.2 alternativeName: NADH dehydrogenase subunit 6
displayName UniProt:P03923 MT-ND6
geneName
  • MT-ND6
  • MTND6
  • NADH6
  • ND6
identifier P03923
isSequenceChanged false
keyword
  • 3D-structure
  • Disease variant
  • Dystonia
  • Electron transport
  • Leber hereditary optic neuropathy
  • Leigh syndrome
  • MELAS syndrome
  • Membrane
  • Mitochondrion
  • Mitochondrion inner membrane
  • NAD
  • Primary mitochondrial disease
  • Proteomics identification
  • Reference proteome
  • Respiratory chain
  • Translocase
  • Transmembrane
  • Transmembrane helix
  • Transport
  • Ubiquinone
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • MT-ND6
otherIdentifier
  • 1553575_PM_at
  • 1553575_at
  • 17100697
  • 17100699
  • 2867408
  • 4037743
  • 4037744
  • 4037745
  • 4037746
  • 4037747
  • 4037748
  • 4037749
  • 4037750
  • 4037751
  • 4037752
  • 4037753
  • 4037754
  • 4541
  • 8113120
  • 8165705
  • 8165707
  • A_23_P317056
  • GO:0005739
  • GO:0005743
  • GO:0006091
  • GO:0006120
  • GO:0007005
  • GO:0008137
  • GO:0009060
  • GO:0016020
  • GO:0016491
  • GO:0031966
  • GO:0032981
  • GO:0042776
  • GO:0045271
  • GO:0055085
  • GO:0055086
  • GO:0065003
  • GO:1901135
  • GO:1902600
  • HMNXSV003052833
  • Hs2Affx.1.46.S1_3p_at
  • RNA143503|tRNA_420_69
  • RNA147303|p0407_imsncRNA822
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NU6M_HUMAN
  • Q34774
  • Q8HG30
sequenceLength 174
species [Species:48887] Homo sapiens
stId uniprot:P03923
url http://purl.uniprot.org/uniprot/P03923
Cite Us!