UniProt:P03508 NS

chain
  • chain:1-121
checksum ABFAC522B4F14854
comment
  • FUNCTION Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.SUBUNIT Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.INTERACTION Average number present in a viral particle is estimated to be 130-200 molecules.SIMILARITY Belongs to the influenza viruses NEP family.
created [InstanceEdit:169110] Gillespie, ME, 2005-11-22 21:39:50
crossReference
databaseName UniProt
dbId 169126
description
  • recommendedName: fullName evidence="1"Nuclear export protein shortName evidence="1"NEP alternativeName: fullName evidence="1"Non-structural protein 2 shortName evidence="1"NS2
displayName UniProt:P03508 NS
geneName
  • NS
identifier P03508
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Host nucleus
  • Host-virus interaction
  • Reference proteome
  • Transport
  • Virion
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • NS
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NEP_I34A1
  • A4GXG8
  • Q20N33
  • Q67266
  • Q71QT4
sequenceLength 121
species [Species:9031716] Influenza A virus
stId uniprot:P03508
url http://purl.uniprot.org/uniprot/P03508
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