UniProt:P03485 M

chain
  • chain:1-252
checksum 2A54EEC87C3D4638
comment
  • FUNCTION Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.FUNCTION Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.SUBUNIT Homodimer and homomultimer. Interacts with NEP. Binds ribonucleocapsid by both interacting with genomic RNA and NP protein. May interact with HA and NA. Cannot bind NP without genomic RNA.INTERACTION Only the first 9 residues are shared by the 2 isoforms.MISCELLANEOUS Most abundant protein in virion. When expressed alone can form virus-like particles in transfected cells.SIMILARITY Belongs to the influenza viruses Matrix protein M1 family.
created [InstanceEdit:169110] Gillespie, ME, 2005-11-22 21:39:50
crossReference
databaseName UniProt
dbId 169124
description
  • recommendedName: fullName evidence="1"Matrix protein 1 shortName evidence="1"M1
displayName UniProt:P03485 M
geneName
  • M
identifier P03485
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Host nucleus
  • Membrane
  • Reference proteome
  • RNA-binding
  • Viral matrix protein
  • Virion
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • M
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • M1_I34A1
  • A4GXH8
  • Q20N36
  • Q77HF4
sequenceLength 252
species [Species:9031716] Influenza A virus
stId uniprot:P03485
url http://purl.uniprot.org/uniprot/P03485
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