Reactome | UniProt:P02679 FGG

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UniProt:P02679 FGG Show undefined attributes

chain	signal peptide:1-26 chain:27-453
checksum	1787204904E0D4BB
comment	FUNCTION Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.SUBUNIT Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.INTERACTION Detected in blood plasma (at protein level).DOMAIN A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.PTM Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.PTM Sulfation of C-terminal tyrosines increases affinity for thrombin.DISEASE The disease is caused by variants affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS The gamma-chain carries the main binding site for the platelet receptor.MISCELLANEOUS Present in about 10% of the fibrinogen molecules in plasma but absent from those in the platelets.ONLINE INFORMATION Fibrinogen entry
crossReference	[DatabaseIdentifier:12174864] PDB:2FFD [DatabaseIdentifier:12285162] Pharos - Targets:P02679 [DatabaseIdentifier:12244737] PRO:P02679 [DatabaseIdentifier:12174876] PDB:1FIC [DatabaseIdentifier:12174902] PDB:2OYH [DatabaseIdentifier:12174898] PDB:3BVH [DatabaseIdentifier:12174889] PDB:2VDR [DatabaseIdentifier:12174899] PDB:2FIB [DatabaseIdentifier:12174875] PDB:3FIB [DatabaseIdentifier:12174882] PDB:2HPC [DatabaseIdentifier:12174905] PDB:2HWL [DatabaseIdentifier:12174890] PDB:3GHG [DatabaseIdentifier:12174867] PDB:2A45 [DatabaseIdentifier:12174900] PDB:2OYI [DatabaseIdentifier:12174896] PDB:1LT9 [DatabaseIdentifier:12174895] PDB:1FZE [DatabaseIdentifier:12174870] PDB:1FZA [DatabaseIdentifier:12174885] PDB:2VDP [DatabaseIdentifier:12170144] PDB:4B60 [DatabaseIdentifier:12174866] PDB:1RE4 [DatabaseIdentifier:12174880] PDB:1N8E [DatabaseIdentifier:12174901] PDB:1RF1 [DatabaseIdentifier:12174879] PDB:1FIB [DatabaseIdentifier:12174891] PDB:1N86 [DatabaseIdentifier:12174878] PDB:2Q9I [DatabaseIdentifier:12174874] PDB:1DUG [DatabaseIdentifier:12174869] PDB:1FZB [DatabaseIdentifier:12174862] PDB:2H43 [DatabaseIdentifier:12174894] PDB:1FZF [DatabaseIdentifier:12174872] PDB:3H32 [DatabaseIdentifier:11492227] ENSEMBL:ENSG00000171557 [DatabaseIdentifier:11599320] ENSEMBL:ENSP00000336829 [DatabaseIdentifier:11599319] ENSEMBL:ENSP00000384860 [DatabaseIdentifier:11722019] ENSEMBL:ENST00000404648 [DatabaseIdentifier:11722018] ENSEMBL:ENST00000336098 [DatabaseIdentifier:11787244] GeneCards:FGG [DatabaseIdentifier:11802685] GlyGen:P02679 [DatabaseIdentifier:11831260] HMDB Protein:HMDBP01954 [DatabaseIdentifier:11840318] HPA:ENSG00000171557-FGG [DatabaseIdentifier:12124853] OpenTargets:ENSG00000171557 [DatabaseIdentifier:12136182] Orphanet:FGG [DatabaseIdentifier:12174863] PDB:2Y7L [DatabaseIdentifier:12174887] PDB:2VDQ [DatabaseIdentifier:12174873] PDB:2HLO [DatabaseIdentifier:12174884] PDB:1LTJ [DatabaseIdentifier:12174881] PDB:2VR3 [DatabaseIdentifier:12174904] PDB:2HOD [DatabaseIdentifier:12174868] PDB:1FZC [DatabaseIdentifier:12174897] PDB:2VDO [DatabaseIdentifier:12174893] PDB:1FZG [DatabaseIdentifier:12174903] PDB:1RF0 [DatabaseIdentifier:12174888] PDB:2XNY [DatabaseIdentifier:12174883] PDB:2Z4E [DatabaseIdentifier:12174865] PDB:1FID [DatabaseIdentifier:12174892] PDB:3E1I [DatabaseIdentifier:12174877] PDB:1RE3 [DatabaseIdentifier:12174886] PDB:2XNX [DatabaseIdentifier:12174871] PDB:3HUS
databaseName	UniProt
dbId	54844
description	recommendedName: Fibrinogen gamma chain
displayName	UniProt:P02679 FGG
geneName	FGG PRO2061
identifier	P02679
isSequenceChanged	false
keyword	3D-structure Alternative splicing Blood coagulation Calcium Coiled coil Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Isopeptide bond Metal-binding Phosphoprotein Proteomics identification Reference proteome Secreted Signal Sulfation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	FGG
otherIdentifier	11724508_s_at 11743159_x_at 16980849 219612_PM_s_at 219612_s_at 2266 2790653 2790654 2790655 2790656 2790657 2790658 2790659 2790662 2790663 2790664 2790666 2790667 2790668 2790669 2790670 2790671 2790672 2790673 2790674 2790675 2790676 2790677 2790678 2790679 2790680 2790681 2790683 2790684 2790685 2790686 2790687 36622_at 64306_at 74775_s_at 8103326 A_23_P148088 GE58226 GE63243 GO:0003013 GO:0005102 GO:0005198 GO:0005201 GO:0005515 GO:0005576 GO:0005577 GO:0005615 GO:0005788 GO:0005886 GO:0007155 GO:0007160 GO:0007596 GO:0007599 GO:0009306 GO:0009897 GO:0009986 GO:0030168 GO:0030312 GO:0031012 GO:0031091 GO:0031093 GO:0031639 GO:0034116 GO:0042730 GO:0045907 GO:0045921 GO:0046872 GO:0050714 GO:0050839 GO:0051258 GO:0051592 GO:0051604 GO:0065003 GO:0070062 GO:0070374 GO:0070527 GO:0072378 GO:0072562 GO:0090277 GO:1900026 GO:1902042 GO:2000352 HMNXSV003023104 ILMN_1703188 ILMN_1737683 ILMN_2315044 M10014_cds1_at PH_hs_0004325 PH_hs_0031320 TC04001663.hg TC04002794.hg g11761634_3p_at g11761634_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-140585] FGG [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-140918] FGG [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-140922] FGG [platelet alpha granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956692] FGG [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956993] p-FGG [endoplasmic reticulum lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000171557] ENSEMBL:ENSG00000171557 FGG [ReferenceDNASequence:12750881] UCSC:P02679 FGG [ReferenceDNASequence:11357747] BioGPS Gene:2266 FGG [ReferenceDNASequence:11401602] COSMIC - genes:FGG FGG [ReferenceDNASequence:11412850] CTD Gene:2266 FGG [ReferenceDNASequence:11438963] dbSNP Gene:2266 FGG [ReferenceDNASequence:11818882] HGNC:3694 FGG [ReferenceDNASequence:11897070] KEGG:hsa:2266 FGG [ReferenceDNASequence:11987536] Monarch:2266 FGG [ReferenceDNASequence:12071629] NCBI Gene:2266 FGG [ReferenceDNASequence:12110218] OMIM:134850 FGG
referenceTranscript	[ReferenceRNASequence:12594455] RefSeq:NM_021870.3 FGG [ReferenceRNASequence:12594456] RefSeq:NM_000509.6 FGG
schemaClass	ReferenceGeneProduct
secondaryIdentifier	FIBG_HUMAN A8K057 P04469 P04470 Q53Y18 Q96A14 Q96KJ3 Q9UC62 Q9UC63 Q9UCF3
sequenceLength	453
species	[Species:48887] Homo sapiens
stId	uniprot:P02679
url	http://purl.uniprot.org/uniprot/P02679

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-140585] FGG [extracellular region] [EntityWithAccessionedSequence:R-HSA-140918] FGG [plasma membrane] [EntityWithAccessionedSequence:R-HSA-140922] FGG [platelet alpha granule lumen] [EntityWithAccessionedSequence:R-HSA-8956692] FGG [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8956993] p-FGG [endoplasmic reticulum lumen]
(referenceSequence)	[ModifiedResidue:8956986] phosphorylated residue at unknown position
(interactor)	[UndirectedInteraction:11167179] UniProt:P02671 <-> UniProt:P02679 (IntAct) [UndirectedInteraction:11245285] UniProt:P78423 <-> UniProt:P02679 (IntAct) [UndirectedInteraction:11285317] UniProt:O60341 <-> UniProt:P02679 (IntAct)