Reactome | UniProt:P02656 APOC3

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UniProt:P02656 APOC3 Show undefined attributes

chain	signal peptide:1-20 chain:21-99
checksum	D4E806339FAE4DA7
comment	FUNCTION Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013).INTERACTION Liver.PTM The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the apolipoprotein C3 family.
crossReference	[DatabaseIdentifier:12413511] RefSeq:NP_000031.1 [DatabaseIdentifier:12285385] Pharos - Targets:P02656 [DatabaseIdentifier:12245024] PRO:P02656 [DatabaseIdentifier:12177235] PDB:2JQ3 [DatabaseIdentifier:12136388] Orphanet:APOC3 [DatabaseIdentifier:12125077] OpenTargets:ENSG00000110245 [DatabaseIdentifier:11840537] HPA:ENSG00000110245-APOC3 [DatabaseIdentifier:11831579] HMDB Protein:HMDBP01987 [DatabaseIdentifier:11802899] GlyGen:P02656 [DatabaseIdentifier:11787466] GeneCards:APOC3 [DatabaseIdentifier:11722559] ENSEMBL:ENST00000227667 [DatabaseIdentifier:11599860] ENSEMBL:ENSP00000227667 [DatabaseIdentifier:11492619] ENSEMBL:ENSG00000110245
databaseName	UniProt
dbId	50114
description	recommendedName: Apolipoprotein C-III shortName: Apo-CIII shortName: ApoC-III alternativeName: Apolipoprotein C3
displayName	UniProt:P02656 APOC3
geneName	APOC3
identifier	P02656
isSequenceChanged	false
keyword	3D-structure Chylomicron Direct protein sequencing Disease variant Glycoprotein Lipid degradation Lipid metabolism Lipid transport Proteomics identification Reference proteome Secreted Sialic acid Signal Transport VLDL
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	APOC3
otherIdentifier	11723791_s_at 16731575 205820_PM_s_at 205820_s_at 3350656 3350657 3350658 3350659 3350660 3350661 3350662 3350664 3350665 3350666 3350668 345 36106_at 7944035 8077204 A_14_P105582 A_23_P203183 GE79025 GO:0005515 GO:0005543 GO:0005576 GO:0005615 GO:0005768 GO:0005769 GO:0006629 GO:0006641 GO:0006869 GO:0007186 GO:0008289 GO:0010897 GO:0010903 GO:0010916 GO:0010987 GO:0010989 GO:0015485 GO:0016042 GO:0019433 GO:0032489 GO:0033344 GO:0033700 GO:0034361 GO:0034363 GO:0034366 GO:0034375 GO:0034379 GO:0034382 GO:0042157 GO:0042627 GO:0042632 GO:0043691 GO:0045717 GO:0045833 GO:0048261 GO:0050995 GO:0055102 GO:0060621 GO:0065003 GO:0070062 GO:0070328 GO:0070653 GO:0098772 HMNXSV003041616 ILMN_1722070 TC11001042.hg TC11002891.hg X01388_at g4557322_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2429646] APOC3 [early endosome] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-174725] APOC3 [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12751236] UCSC:P02656 APOC3 [ReferenceDNASequence:12110425] OMIM:107720 APOC3 [ReferenceDNASequence:12072027] NCBI Gene:345 APOC3 [ReferenceDNASequence:11987934] Monarch:345 APOC3 [ReferenceDNASequence:11897429] KEGG:hsa:345 APOC3 [ReferenceDNASequence:11819106] HGNC:610 APOC3 [ReferenceDNASequence:11439027] dbSNP Gene:345 APOC3 [ReferenceDNASequence:11413191] CTD Gene:345 APOC3 [ReferenceDNASequence:11401661] COSMIC - genes:APOC3 APOC3 [ReferenceDNASequence:11358145] BioGPS Gene:345 APOC3 [ReferenceDNASequence:ensembl:ENSG00000110245] ENSEMBL:ENSG00000110245 APOC3
referenceTranscript	[ReferenceRNASequence:12595213] RefSeq:NM_000040.3 APOC3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	APOC3_HUMAN Q08E83 Q6Q786
sequenceLength	99
species	[Species:48887] Homo sapiens
stId	uniprot:P02656
url	http://purl.uniprot.org/uniprot/P02656

Referrals

(interactor)	[UndirectedInteraction:11153627] UniProt:P02656 <-> UniProt:Q5JX71 (IntAct) [UndirectedInteraction:11153625] UniProt:P02656 <-> UniProt:Q9Y282 (IntAct) [UndirectedInteraction:11153623] UniProt:P02656 <-> UniProt:Q8TED1 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2429646] APOC3 [early endosome] [EntityWithAccessionedSequence:R-HSA-174725] APOC3 [extracellular region]