Reactome | UniProt:P02468 Lamc1

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UniProt:P02468 Lamc1 Show undefined attributes

chain	signal peptide:1-33 chain:34-1607
checksum	81B7B08E4869F242
comment	FUNCTION Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway (PubMed:9454835).SUBUNIT Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) (PubMed:9454835). Gamma-1 is also a subunit of laminin-2 (laminin-211 or merosin), laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6 (laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9 (laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521). Interacts with SVEP1 (PubMed:36792666).INTERACTION Found in the basement membranes (major component).DOMAIN The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.DOMAIN Domains VI and IV are globular.
crossReference	[DatabaseIdentifier:12240705] PRO:P02468 [DatabaseIdentifier:12161583] PDB:1KLO [DatabaseIdentifier:12161581] PDB:1NPE [DatabaseIdentifier:12161574] PDB:5MC9 [DatabaseIdentifier:12161582] PDB:4AQT [DatabaseIdentifier:12161584] PDB:1TLE [DatabaseIdentifier:11930977] MGI:99914 [DatabaseIdentifier:11800305] GlyGen:P02468
databaseName	UniProt
dbId	94529
description	recommendedName: Laminin subunit gamma-1 alternativeName: Laminin B2 chain alternativeName: Laminin-1 subunit gamma alternativeName: Laminin-10 subunit gamma alternativeName: Laminin-11 subunit gamma alternativeName: Laminin-2 subunit gamma alternativeName: Laminin-3 subunit gamma alternativeName: Laminin-4 subunit gamma alternativeName: Laminin-6 subunit gamma alternativeName: Laminin-7 subunit gamma alternativeName: Laminin-8 subunit gamma alternativeName: Laminin-9 subunit gamma alternativeName: S-laminin subunit gamma shortName: S-LAM gamma
displayName	UniProt:P02468 Lamc1
geneName	Lamc1 Lamb-2 Lamc-1
identifier	P02468
isSequenceChanged	false
keyword	3D-structure Basement membrane Cell adhesion Coiled coil Disulfide bond Extracellular matrix Glycoprotein Laminin EGF-like domain Phosphoprotein Reference proteome Repeat Secreted Signal
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	Lamc1
physicalEntity	[EntityWithAccessionedSequence:R-MMU-2533905] Laminin gamma-1 C-term fragment [extracellular region] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2533941] Laminin gamma-1 N-term fragment [extracellular region] - Mus musculus [EntityWithAccessionedSequence:R-MMU-443597] Lamc1 [extracellular region] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12746928] UCSC:P02468 Lamc1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	LAMC1_MOUSE
sequenceLength	1607
species	[Species:48892] Mus musculus
stId	uniprot:P02468
url	http://purl.uniprot.org/uniprot/P02468

Referrals

(interactor)	[UndirectedInteraction:11144603] UniProt:P10493 <-> UniProt:P02468 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-2533905] Laminin gamma-1 C-term fragment [extracellular region] [EntityWithAccessionedSequence:R-MMU-2533941] Laminin gamma-1 N-term fragment [extracellular region] [EntityWithAccessionedSequence:R-MMU-443597] Lamc1 [extracellular region]