Reactome | UniProt:P02406 RPL28

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UniProt:P02406 RPL28 Show undefined attributes

chain	initiator methionine:1 chain:2-149
checksum	B34C325C01E14ACB
comment	FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.SUBUNIT Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:22096102, PubMed:9559554).SUBCELLULAR LOCATION Belongs to the universal ribosomal protein uL15 family.
crossReference	[DatabaseIdentifier:12142311] PDB:8UT0 [DatabaseIdentifier:12404408] RefSeq:NP_011412.1 [DatabaseIdentifier:12240885] PRO:P02406 [DatabaseIdentifier:12142389] PDB:8CKU [DatabaseIdentifier:12144989] PDB:8AGT [DatabaseIdentifier:12144999] PDB:5T6R [DatabaseIdentifier:12142368] PDB:6TB3 [DatabaseIdentifier:12144979] PDB:6YLG [DatabaseIdentifier:12142394] PDB:5TGA [DatabaseIdentifier:12145011] PDB:7OH3 [DatabaseIdentifier:12145006] PDB:6N8M [DatabaseIdentifier:12142353] PDB:8ZHC [DatabaseIdentifier:12144998] PDB:7UQZ [DatabaseIdentifier:12144990] PDB:8AGU [DatabaseIdentifier:12150868] PDB:7U0H [DatabaseIdentifier:12144983] PDB:5T62 [DatabaseIdentifier:12145004] PDB:6N8K [DatabaseIdentifier:12142346] PDB:3J78 [DatabaseIdentifier:12144986] PDB:8AGZ [DatabaseIdentifier:12142383] PDB:8P4V [DatabaseIdentifier:12142424] PDB:5TGM [DatabaseIdentifier:12144994] PDB:5APN [DatabaseIdentifier:12144980] PDB:7TOO [DatabaseIdentifier:12152564] PDB:8PFR [DatabaseIdentifier:12144982] PDB:8AGX [DatabaseIdentifier:12144995] PDB:6YLX [DatabaseIdentifier:12142400] PDB:5DGV [DatabaseIdentifier:12142348] PDB:3J6Y [DatabaseIdentifier:12144981] PDB:7UQB [DatabaseIdentifier:12142344] PDB:7MPI [DatabaseIdentifier:12144993] PDB:5APO [DatabaseIdentifier:12144991] PDB:6OIG [DatabaseIdentifier:12142345] PDB:6SNT [DatabaseIdentifier:12142351] PDB:8ZHB [DatabaseIdentifier:12145005] PDB:6N8J [DatabaseIdentifier:12145000] PDB:8HFR [DatabaseIdentifier:12144987] PDB:6YLY [DatabaseIdentifier:12142347] PDB:3J6X [DatabaseIdentifier:12142420] PDB:8CMJ [DatabaseIdentifier:12145001] PDB:6M62 [DatabaseIdentifier:12142364] PDB:6XIQ [DatabaseIdentifier:12142371] PDB:8ZGR [DatabaseIdentifier:12142343] PDB:7NRD [DatabaseIdentifier:12144984] PDB:8AGV [DatabaseIdentifier:12145012] PDB:5JCS [DatabaseIdentifier:12145002] PDB:8BJQ [DatabaseIdentifier:12145007] PDB:6N8L [DatabaseIdentifier:12145008] PDB:6N8O [DatabaseIdentifier:12142404] PDB:5DGF [DatabaseIdentifier:12142362] PDB:6XIR [DatabaseIdentifier:12144996] PDB:7OF1 [DatabaseIdentifier:12144978] PDB:6YLH [DatabaseIdentifier:12144997] PDB:6S05 [DatabaseIdentifier:12142407] PDB:6T4Q [DatabaseIdentifier:12142357] PDB:3J77 [DatabaseIdentifier:12142391] PDB:8XU8 [DatabaseIdentifier:12144977] PDB:7TOP [DatabaseIdentifier:12144985] PDB:8AGW [DatabaseIdentifier:12142356] PDB:8ZGY [DatabaseIdentifier:12144988] PDB:8BIP [DatabaseIdentifier:12144992] PDB:7AZY [DatabaseIdentifier:12145010] PDB:6N8N [DatabaseIdentifier:12142372] PDB:8ZH3 [DatabaseIdentifier:12142423] PDB:5ON6 [DatabaseIdentifier:12142403] PDB:5DGE [DatabaseIdentifier:12144975] PDB:7UOO [DatabaseIdentifier:12142312] PDB:6Q8Y [DatabaseIdentifier:12142410] PDB:4U50 [DatabaseIdentifier:12142308] PDB:4U4Z [DatabaseIdentifier:12142382] PDB:6Z6K [DatabaseIdentifier:12142399] PDB:4U3N [DatabaseIdentifier:12139467] PDB:4V91 [DatabaseIdentifier:12140964] PDB:4V5Z [DatabaseIdentifier:12142301] PDB:5NDW [DatabaseIdentifier:12144965] PDB:6HD7 [DatabaseIdentifier:12152563] PDB:4V4B [DatabaseIdentifier:12142327] PDB:5MEI [DatabaseIdentifier:12142325] PDB:6HHQ [DatabaseIdentifier:12144973] PDB:6FT6 [DatabaseIdentifier:12142292] PDB:8CG8 [DatabaseIdentifier:12142314] PDB:8CGN [DatabaseIdentifier:12142321] PDB:6TNU [DatabaseIdentifier:12142320] PDB:5DAT [DatabaseIdentifier:12142307] PDB:4U4Y [DatabaseIdentifier:12142413] PDB:4U4Q [DatabaseIdentifier:12142306] PDB:4U56 [DatabaseIdentifier:12142386] PDB:8BQX [DatabaseIdentifier:12144959] PDB:7ZS5 [DatabaseIdentifier:12144957] PDB:5H4P [DatabaseIdentifier:12142298] PDB:5MC6 [DatabaseIdentifier:12142425] PDB:7ZUX [DatabaseIdentifier:12142419] PDB:4V6I [DatabaseIdentifier:12142396] PDB:8PNN [DatabaseIdentifier:12144963] PDB:6R87 [DatabaseIdentifier:12144972] PDB:4V8T [DatabaseIdentifier:12142377] PDB:8T2Y [DatabaseIdentifier:12142378] PDB:5OBM [DatabaseIdentifier:12140531] PDB:7B7D [DatabaseIdentifier:12142415] PDB:7ZW0 [DatabaseIdentifier:12142409] PDB:4U4O [DatabaseIdentifier:12144961] PDB:7Z34 [DatabaseIdentifier:12142338] PDB:8Z70 [DatabaseIdentifier:12142315] PDB:4U6F [DatabaseIdentifier:12144958] PDB:9OFV [DatabaseIdentifier:12144968] PDB:6RZZ [DatabaseIdentifier:12142341] PDB:7MPJ [DatabaseIdentifier:12142379] PDB:8EVP [DatabaseIdentifier:12142392] PDB:6GQB [DatabaseIdentifier:12150872] PDB:7BT6 [DatabaseIdentifier:12144976] PDB:7V08 [DatabaseIdentifier:12142313] PDB:5DC3 [DatabaseIdentifier:12144967] PDB:8AAF [DatabaseIdentifier:12142401] PDB:8CDL [DatabaseIdentifier:12144971] PDB:6QIK [DatabaseIdentifier:12142397] PDB:4U3M [DatabaseIdentifier:12144970] PDB:8Y0U [DatabaseIdentifier:12142342] PDB:7NRC [DatabaseIdentifier:12142322] PDB:9F9S [DatabaseIdentifier:12144960] PDB:6QTZ [DatabaseIdentifier:12140535] PDB:8Z71 [DatabaseIdentifier:12142405] PDB:8CF5 [DatabaseIdentifier:12142381] PDB:8T2Z [DatabaseIdentifier:12142365] PDB:8EVR [DatabaseIdentifier:12142421] PDB:8CEH [DatabaseIdentifier:12142339] PDB:8CIV [DatabaseIdentifier:12142334] PDB:4V8Y [DatabaseIdentifier:12142290] PDB:4V7R [DatabaseIdentifier:12142412] PDB:5NDG [DatabaseIdentifier:12142369] PDB:8T3C [DatabaseIdentifier:12142330] PDB:5TBW [DatabaseIdentifier:12142393] PDB:8K2D [DatabaseIdentifier:12142388] PDB:6GQV [DatabaseIdentifier:12142418] PDB:5M1J [DatabaseIdentifier:12142414] PDB:4U52 [DatabaseIdentifier:12144974] PDB:3JCT [DatabaseIdentifier:12144964] PDB:6R86 [DatabaseIdentifier:12142384] PDB:6Z6J [DatabaseIdentifier:12142398] PDB:8CDR [DatabaseIdentifier:12142303] PDB:4U55 [DatabaseIdentifier:12142375] PDB:8T2X [DatabaseIdentifier:12142395] PDB:5FCJ [DatabaseIdentifier:12144969] PDB:4V7F [DatabaseIdentifier:12142380] PDB:7ZRS [DatabaseIdentifier:12142411] PDB:4U51 [DatabaseIdentifier:12142417] PDB:4U53 [DatabaseIdentifier:12142402] PDB:5FCI [DatabaseIdentifier:12142332] PDB:8K82 [DatabaseIdentifier:12142319] PDB:4V88 [DatabaseIdentifier:12142374] PDB:6WOO [DatabaseIdentifier:12142336] PDB:4V8Z [DatabaseIdentifier:12142408] PDB:4U4N [DatabaseIdentifier:12142370] PDB:8T3D [DatabaseIdentifier:12142416] PDB:4U4R [DatabaseIdentifier:12142361] PDB:8T3B [DatabaseIdentifier:12142426] PDB:7ZUW [DatabaseIdentifier:12142385] PDB:8CCS [DatabaseIdentifier:12142363] PDB:8EVQ [DatabaseIdentifier:12142422] PDB:4U3U [DatabaseIdentifier:12144966] PDB:6RI5 [DatabaseIdentifier:12144962] PDB:6R84 [DatabaseIdentifier:12142305] PDB:4U4U [DatabaseIdentifier:12142300] PDB:6I7O [DatabaseIdentifier:12142367] PDB:8T3F [DatabaseIdentifier:12142299] PDB:5NDV [DatabaseIdentifier:12142366] PDB:8T3E [DatabaseIdentifier:12142354] PDB:6GQ1 [DatabaseIdentifier:12142309] PDB:6SV4 [DatabaseIdentifier:12142335] PDB:7N8B [DatabaseIdentifier:12142350] PDB:8EWC [DatabaseIdentifier:12142323] PDB:6T83 [DatabaseIdentifier:12142337] PDB:7ZPQ [DatabaseIdentifier:11488245] ENSEMBL:YGL103W [DatabaseIdentifier:11593479] ENSEMBL:YGL103W [DatabaseIdentifier:11716178] ENSEMBL:YGL103W_mRNA [DatabaseIdentifier:12142302] PDB:5JUO [DatabaseIdentifier:12142349] PDB:8EWB [DatabaseIdentifier:12142293] PDB:5JUP [DatabaseIdentifier:12142333] PDB:8P9A [DatabaseIdentifier:12142360] PDB:8EVT [DatabaseIdentifier:12142295] PDB:5JUU [DatabaseIdentifier:12140536] PDB:8YLR [DatabaseIdentifier:12142304] PDB:5LYB [DatabaseIdentifier:12142352] PDB:8BQD [DatabaseIdentifier:12142326] PDB:6T7T [DatabaseIdentifier:12144956] PDB:9F58 [DatabaseIdentifier:12142329] PDB:6T7I [DatabaseIdentifier:12142324] PDB:8EUB [DatabaseIdentifier:12142328] PDB:8UTI [DatabaseIdentifier:12142316] PDB:8BN3 [DatabaseIdentifier:12144951] PDB:7OHQ [DatabaseIdentifier:12144954] PDB:7UG6 [DatabaseIdentifier:12152562] PDB:8P8M [DatabaseIdentifier:12144955] PDB:6QT0 [DatabaseIdentifier:12150861] PDB:7BTB [DatabaseIdentifier:12144952] PDB:8P8U [DatabaseIdentifier:12142340] PDB:8T30 [DatabaseIdentifier:12142294] PDB:5JUS [DatabaseIdentifier:12142331] PDB:5I4L [DatabaseIdentifier:12150864] PDB:6ELZ [DatabaseIdentifier:12142297] PDB:8P85 [DatabaseIdentifier:12142359] PDB:8T3A [DatabaseIdentifier:12144953] PDB:5GAK [DatabaseIdentifier:12152561] PDB:8P8N [DatabaseIdentifier:12142318] PDB:6S47 [DatabaseIdentifier:12142296] PDB:5JUT [DatabaseIdentifier:12142358] PDB:8EVS [DatabaseIdentifier:12140532] PDB:8YLD [DatabaseIdentifier:12150876] PDB:7OHV
databaseName	UniProt
dbId	100141
description	recommendedName: fullName evidence="6"Large ribosomal subunit protein uL15 alternativeName: fullName evidence="7"60S ribosomal protein L28 alternativeName: L27a alternativeName: L29 alternativeName: RP44 alternativeName: RP62 alternativeName: YL24
displayName	UniProt:P02406 RPL28
geneName	RPL28 CYH2 YGL103W
identifier	P02406
isSequenceChanged	false
keyword	3D-structure Cytoplasm Isopeptide bond Reference proteome Ribonucleoprotein Ribosomal protein Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPL28
otherIdentifier	852775 GO:0002181 GO:0003723 GO:0003735 GO:0005198 GO:0005575 GO:0005634 GO:0005737 GO:0005829 GO:0005840 GO:0006412 GO:0015934 GO:0022625 GO:1990904
physicalEntity	[EntityWithAccessionedSequence:R-SCE-72442] RPL28 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-9633254] RPL28 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-9630984] RPL28 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-9630970] RPL28 [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11353535] BioGPS Gene:852775 RPL28 [ReferenceDNASequence:12747097] UCSC:P02406 RPL28 [ReferenceDNASequence:11893160] KEGG:sce:YGL103W RPL28 [ReferenceDNASequence:11983324] Monarch:852775 RPL28 [ReferenceDNASequence:12067417] NCBI Gene:852775 RPL28
referenceTranscript	[ReferenceRNASequence:12586125] RefSeq:NM_001180968.1 RPL28
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RL28_YEAST D6VU43
sequenceLength	149
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P02406
url	http://purl.uniprot.org/uniprot/P02406

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-SCE-72442] RPL28 [cytosol] [EntityWithAccessionedSequence:R-SCE-9633254] RPL28 [cytosol] [EntityWithAccessionedSequence:R-SCE-9630984] RPL28 [nucleoplasm] [EntityWithAccessionedSequence:R-SCE-9630970] RPL28 [nucleoplasm]
(referenceSequence)	[ModifiedResidue:11104523] modified L-histidine residue at 39 (in Homo sapiens)
(interactor)	[UndirectedInteraction:11306529] UniProt:Q05468 <-> UniProt:P02406 (IntAct)

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