Reactome | UniProt:P01833 PIGR

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UniProt:P01833 PIGR Show undefined attributes

chain	signal peptide:1-18 chain:19-764 chain:19-603
checksum	927461F4EB3B05C7
comment	FUNCTION Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.FUNCTION Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244).SUBUNIT Interacts (mainly via CDR1-like domain) with dimeric IgA (PubMed:15530357). Interacts (mainly via CDR2-like domain) with pentameric IgM (PubMed:10229845, PubMed:32029689).SUBUNIT Either free or part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteolytic product of PIGR) (PubMed:16543244, PubMed:19079336, PubMed:32029686, PubMed:8292260). Free secretory component interacts with bacterial antigens toxA of C.difficile and eaeA of E.coli (PubMed:16543244).INTERACTION The Ig-like V-type 1/D1 domain contains three complementarity determining region-like loops CDR1-3, which mediate interaction with IgA and IgM.PTM N-glycosylated. N-glycosylation is required for anchoring IgA molecules to mucus, but is not necessary for Ig binding.
crossReference	[DatabaseIdentifier:12457407] RefSeq:XP_011507931.1 [DatabaseIdentifier:12457408] RefSeq:NP_002635.2 [DatabaseIdentifier:12457406] RefSeq:XP_054193006.1 [DatabaseIdentifier:12285791] Pharos - Targets:P01833 [DatabaseIdentifier:12265246] PRO:P01833 [DatabaseIdentifier:12180936] PDB:1XED [DatabaseIdentifier:12178897] PDB:3CHN [DatabaseIdentifier:12178894] PDB:3CM9 [DatabaseIdentifier:12171036] PDB:6UE9 [DatabaseIdentifier:12171014] PDB:6KXS [DatabaseIdentifier:12171015] PDB:6LXW [DatabaseIdentifier:12171016] PDB:7YSG [DatabaseIdentifier:12171034] PDB:6UE7 [DatabaseIdentifier:12171027] PDB:7K0C [DatabaseIdentifier:12180937] PDB:5D4K [DatabaseIdentifier:12171029] PDB:6UEA [DatabaseIdentifier:12180935] PDB:2OCW [DatabaseIdentifier:12171033] PDB:6LX3 [DatabaseIdentifier:12171028] PDB:8SKU [DatabaseIdentifier:12171037] PDB:6UE8 [DatabaseIdentifier:12171026] PDB:8SKV [DatabaseIdentifier:12125506] OpenTargets:ENSG00000162896 [DatabaseIdentifier:11840959] HPA:ENSG00000162896-PIGR [DatabaseIdentifier:11803410] GlyGen:P01833 [DatabaseIdentifier:11787890] GeneCards:PIGR [DatabaseIdentifier:11753385] ENSEMBL:ENST00000356495 [DatabaseIdentifier:11630686] ENSEMBL:ENSP00000348888 [DatabaseIdentifier:11514336] ENSEMBL:ENSG00000162896
databaseName	UniProt
dbId	61726
description	recommendedName: Polymeric immunoglobulin receptor shortName: PIgR shortName: Poly-Ig receptor alternativeName: Hepatocellular carcinoma-associated protein TB6 component recommendedName: Secretory component /component
displayName	UniProt:P01833 PIGR
geneName	PIGR
identifier	P01833
isSequenceChanged	false
keyword	3D-structure Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	PIGR
otherIdentifier	11716109_a_at 11716110_s_at 11716111_x_at 11716112_at 16698718 204213_PM_at 204213_at 226147_PM_s_at 226147_s_at 2453002 2453007 2453008 2453009 2453010 2453011 2453012 2453013 2453015 2453016 2453017 2453018 2453019 2453020 2453021 2453022 2453023 2453024 2453025 2453027 34005_at 45294_at 5284 7923929 A_24_P844984 GE61415 GO:0001580 GO:0001790 GO:0001792 GO:0002415 GO:0004888 GO:0005576 GO:0005615 GO:0005886 GO:0007165 GO:0007173 GO:0012505 GO:0016020 GO:0030659 GO:0035577 GO:0038093 GO:0043113 GO:0043235 GO:0070062 GO:0071751 GO:0098588 HMNXSV003017713 Hs.205126.0.A1_3p_a_at ILMN_1685387 PH_hs_0012007 TC01003768.hg X73079_at g11342673_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-197861] PIGR(19-603) [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6799166] PIGR(19-603) [azurophil granule membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12764575] UCSC:P01833 PIGR [ReferenceDNASequence:12110806] OMIM:173880 PIGR [ReferenceDNASequence:12092627] NCBI Gene:5284 PIGR [ReferenceDNASequence:12008534] Monarch:5284 PIGR [ReferenceDNASequence:11915980] KEGG:hsa:5284 PIGR [ReferenceDNASequence:11819539] HGNC:8968 PIGR [ReferenceDNASequence:11441013] dbSNP Gene:5284 PIGR [ReferenceDNASequence:11413868] CTD Gene:5284 PIGR [ReferenceDNASequence:11403402] COSMIC - genes:PIGR PIGR [ReferenceDNASequence:11378745] BioGPS Gene:5284 PIGR [ReferenceDNASequence:ensembl:ENSG00000162896] ENSEMBL:ENSG00000162896 PIGR
referenceTranscript	[ReferenceRNASequence:12638881] RefSeq:NM_002644.3 PIGR [ReferenceRNASequence:12638880] RefSeq:XM_011509629.2 PIGR [ReferenceRNASequence:12638879] RefSeq:XM_054337031.1 PIGR
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PIGR_HUMAN Q68D81 Q8IZY7
sequenceLength	764
species	[Species:48887] Homo sapiens
stId	uniprot:P01833
url	http://purl.uniprot.org/uniprot/P01833

Referrals

(interactor)	[UndirectedInteraction:11225347] UniProt:Q00403 <-> UniProt:P01833 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-197861] PIGR(19-603) [plasma membrane] [EntityWithAccessionedSequence:R-HSA-6799166] PIGR(19-603) [azurophil granule membrane]