UniProt:P01139 Ngf

chain
  • signal peptide:1-18
  • propeptide:19-121
  • chain:122-241
checksum 164465E1DC550081
comment
  • FUNCTION Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:20036257). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:22649032). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786). In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (PubMed:20036257). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer (PubMed:22649032, PubMed:26144237). The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (PubMed:22649032).SUBUNIT Homodimer (PubMed:1956407, PubMed:20036257, PubMed:22649032, PubMed:26144237, PubMed:30061605, PubMed:8201620). The homodimer interacts with a single NTRK1 chain (PubMed:22649032). The homodimer interacts with a single NGFR chain (By similarity). The NGF dimer interacts with a single SORCS2 chain (via extracellular domain) (PubMed:30061605). The NGF precursor (proNGF) binds to a receptor complex formed by SORT1 and NGFR, which leads to NGF endocytosis (PubMed:20036257). Both mature NGF and the immature NGF precursor (proNGF) interact with SORCS2 and with the heterodimer formed by SORCS2 and NGFR (via extracellular domains) (PubMed:22155786, PubMed:30061605). The NGF precursor (proNGF) has much higher affinity for SORCS2 than mature NGF (PubMed:24908487). The NGF precursor (proNGF) has much higher affinity for SORT1 than mature NGF (PubMed:20036257). Interacts with ADAM10 in a divalent cation-dependent manner (By similarity). Interacts with SORCS3 (By similarity).SUBCELLULAR LOCATION ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR.TISSUE SPECIFICITY Detected in submaxillary gland (at protein level) (PubMed:1284621). Highly expressed in male submaxillary gland. Levels are much lower in female submaxillary gland (PubMed:1284621, PubMed:6336309).INDUCTION Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain.SIMILARITY Belongs to the NGF-beta family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.
crossReference
databaseName UniProt
dbId 96246
description
  • recommendedName: Beta-nerve growth factor shortName: Beta-NGF
displayName UniProt:P01139 Ngf
geneName
  • Ngf
  • Ngfb
identifier P01139
isSequenceChanged false
keyword
  • 3D-structure
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disulfide bond
  • Endosome
  • Glycoprotein
  • Growth factor
  • Lipid-binding
  • Metalloenzyme inhibitor
  • Metalloprotease inhibitor
  • Protease inhibitor
  • Reference proteome
  • Secreted
  • Signal
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • Ngf
otherIdentifier
  • 102298_at
  • 10494817
  • 1419675_at
  • 17401066
  • 18049
  • 4357502
  • 4398995
  • 4434209
  • 4486965
  • 4544663
  • 5129885
  • 5163657
  • 5196467
  • 5334168
  • 5533471
  • 5601758
  • A_51_P381208
  • A_55_P2074337
  • GE36704
  • GO:0004857
  • GO:0005102
  • GO:0005163
  • GO:0005576
  • GO:0005615
  • GO:0005768
  • GO:0005788
  • GO:0007165
  • GO:0007169
  • GO:0007422
  • GO:0007623
  • GO:0008021
  • GO:0008083
  • GO:0008191
  • GO:0008289
  • GO:0008625
  • GO:0010628
  • GO:0010976
  • GO:0014042
  • GO:0019233
  • GO:0021675
  • GO:0030297
  • GO:0030414
  • GO:0030424
  • GO:0030425
  • GO:0031175
  • GO:0031398
  • GO:0031410
  • GO:0031904
  • GO:0038180
  • GO:0043069
  • GO:0043524
  • GO:0045664
  • GO:0045773
  • GO:0046579
  • GO:0046928
  • GO:0048011
  • GO:0048018
  • GO:0048672
  • GO:0048675
  • GO:0048812
  • GO:0048856
  • GO:0050804
  • GO:0050877
  • GO:0051279
  • GO:0051388
  • GO:0051402
  • GO:0051897
  • GO:0070374
  • GO:0097192
  • GO:0098772
  • ILMN_2660233
  • ILMN_2937596
  • m14805_s_at
  • mMC017465
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NGF_MOUSE
  • Q63864
  • Q6LDB7
sequenceLength 241
species [Species:48892] Mus musculus
stId uniprot:P01139
url http://purl.uniprot.org/uniprot/P01139
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