Reactome | UniProt:P01132 Egf

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UniProt:P01132 Egf Show undefined attributes

chain	signal peptide:1-28 chain:29-1217 chain:977-1029
checksum	28F35C928280D31B
comment	FUNCTION EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).SUBUNIT Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). Interacts with RHBDF2.
crossReference	[DatabaseIdentifier:12447000] RefSeq:NP_034243.2 [DatabaseIdentifier:12260903] PRO:P01132 [DatabaseIdentifier:12161627] PDB:1EPG [DatabaseIdentifier:12161622] PDB:1EPJ [DatabaseIdentifier:12161621] PDB:1EGF [DatabaseIdentifier:12161623] PDB:3EGF [DatabaseIdentifier:12161625] PDB:1EPI [DatabaseIdentifier:12161603] PDB:1GK5 [DatabaseIdentifier:12161626] PDB:1EPH [DatabaseIdentifier:12161624] PDB:1A3P [DatabaseIdentifier:11930978] MGI:95290 [DatabaseIdentifier:11800310] GlyGen:P01132 [DatabaseIdentifier:11745793] ENSEMBL:ENSMUST00000029653 [DatabaseIdentifier:11623094] ENSEMBL:ENSMUSP00000029653 [DatabaseIdentifier:11508760] ENSEMBL:ENSMUSG00000028017
databaseName	UniProt
dbId	89745
description	recommendedName: Pro-epidermal growth factor shortName: EGF component recommendedName: Epidermal growth factor /component
displayName	UniProt:P01132 Egf
geneName	Egf
identifier	P01132
isSequenceChanged	false
keyword	3D-structure Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Growth factor Membrane Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	Egf
otherIdentifier	102774_at 10502105 13645 1418093_a_at 17410275 4320635 4336785 4416432 4485032 4524127 4525875 4551309 4553083 4564585 4621519 4629594 4652272 4665031 4709106 4711666 4725190 4731511 4744375 4772083 4781545 4819342 4833894 4853903 4862995 4896143 4911611 5075226 5109040 5160213 5188041 5217729 5286486 5291191 5373148 5390956 5392091 5463700 5482604 5486846 5487663 5499833 5513884 5515375 5521569 5562383 5570506 5570987 A_52_P38627 A_55_P2733187 A_55_P2736929 A_55_P2822952 GE35346 GO:0001525 GO:0001938 GO:0002092 GO:0005085 GO:0005154 GO:0005509 GO:0005515 GO:0005576 GO:0005615 GO:0005886 GO:0006355 GO:0006511 GO:0007173 GO:0008083 GO:0008283 GO:0008284 GO:0010595 GO:0010604 GO:0010628 GO:0016020 GO:0016567 GO:0021930 GO:0021940 GO:0030297 GO:0030335 GO:0038134 GO:0042059 GO:0042327 GO:0043388 GO:0043410 GO:0045840 GO:0045893 GO:0046425 GO:0048018 GO:0048513 GO:0048731 GO:0048754 GO:0048856 GO:0050673 GO:0050679 GO:0051048 GO:0051049 GO:0051223 GO:0051897 GO:0060749 GO:0070062 GO:0070086 GO:0070371 GO:0071944 GO:0080090 GO:0090263 GO:0090279 GO:0090370 GO:0098772 GO:1900127 GO:1902966 GO:1905278 GO:2000008 GO:2000060 ILMN_1240039 ILMN_2684104 mMC005392 v00741_s_at
physicalEntity	[EntityWithAccessionedSequence:R-MMU-8869086] Egf [clathrin-coated endocytic vesicle membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-54209] Egf [extracellular region] - Mus musculus [EntityWithAccessionedSequence:R-MMU-139875] Egf [platelet alpha granule lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-179794] EGF [extracellular region] - Mus musculus [EntityWithAccessionedSequence:R-MMU-179798] pro-EGF precursor [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-179863] Egf [extracellular region] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12761478] UCSC:P01132 Egf [ReferenceDNASequence:12087568] NCBI Gene:13645 Egf [ReferenceDNASequence:12003475] Monarch:13645 Egf [ReferenceDNASequence:11911488] KEGG:mmu:13645 Egf [ReferenceDNASequence:11373686] BioGPS Gene:13645 Egf
referenceTranscript	[ReferenceRNASequence:12628545] RefSeq:NM_010113.4 Egf
schemaClass	ReferenceGeneProduct
secondaryIdentifier	EGF_MOUSE E9QNX6 Q569W5 Q6P9J2
sequenceLength	1217
species	[Species:48892] Mus musculus
stId	uniprot:P01132
url	http://purl.uniprot.org/uniprot/P01132

Referrals

(interactor)

[UndirectedInteraction:11129853] UniProt:P01132 <-> UniProt:Q80WQ6 (IntAct)

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