Reactome | UniProt:P00128 QCR7

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UniProt:P00128 QCR7 Show undefined attributes

chain	chain:1-127
checksum	1F1BA3DB6C4067B4
comment	FUNCTION Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.SUBUNIT Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III(2)IV and III(2)IV(2)) (PubMed:10764779, PubMed:10775262, PubMed:30598554, PubMed:30598556).SUBCELLULAR LOCATION Present with 10100 molecules/cell in log phase SD medium.SIMILARITY Belongs to the UQCRB/QCR7 family.CAUTION Was originally thought to be the ubiquinone-binding protein (QP-C).
crossReference	[DatabaseIdentifier:12318221] RefSeq:NP_010818.1 [DatabaseIdentifier:12243420] PRO:P00128 [DatabaseIdentifier:12168682] PDB:8YIO [DatabaseIdentifier:12168681] PDB:8YIN [DatabaseIdentifier:12168680] PDB:3CXH [DatabaseIdentifier:12168683] PDB:8YIL [DatabaseIdentifier:12149755] PDB:6T15 [DatabaseIdentifier:12149754] PDB:6T0B [DatabaseIdentifier:12168672] PDB:1EZV [DatabaseIdentifier:12168674] PDB:1P84 [DatabaseIdentifier:12168679] PDB:2IBZ [DatabaseIdentifier:12149749] PDB:9BPB [DatabaseIdentifier:12168675] PDB:8YHQ [DatabaseIdentifier:12168678] PDB:3CX5 [DatabaseIdentifier:12168676] PDB:8ZMT [DatabaseIdentifier:12149750] PDB:8E7S [DatabaseIdentifier:12149753] PDB:9ETZ [DatabaseIdentifier:12149747] PDB:6GIQ [DatabaseIdentifier:12149748] PDB:8EC0 [DatabaseIdentifier:12149756] PDB:6HU9 [DatabaseIdentifier:12149752] PDB:6YMX [DatabaseIdentifier:12168673] PDB:1KYO [DatabaseIdentifier:12168677] PDB:4PD4 [DatabaseIdentifier:12168671] PDB:1KB9 [DatabaseIdentifier:11659970] ENSEMBL:YDR529C_mRNA [DatabaseIdentifier:11537271] ENSEMBL:YDR529C [DatabaseIdentifier:11448744] ENSEMBL:YDR529C
databaseName	UniProt
dbId	104332
description	recommendedName: Cytochrome b-c1 complex subunit 7, mitochondrial alternativeName: Complex III subunit 7 alternativeName: Complex III subunit VII alternativeName: Ubiquinol-cytochrome c oxidoreductase subunit 7 alternativeName: Ubiquinol-cytochrome c reductase 14 kDa protein
displayName	UniProt:P00128 QCR7
geneName	QCR7 CRO1 UCR7 YDR529C D9719.32
identifier	P00128
isSequenceChanged	false
keyword	3D-structure Electron transport Membrane Mitochondrion Mitochondrion inner membrane Reference proteome Respiratory chain Transport
modified	[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
moleculeType	Protein
name	QCR7
otherIdentifier	852142 GO:0003674 GO:0005575 GO:0005739 GO:0005743 GO:0005750 GO:0006091 GO:0006122 GO:0006811 GO:0007005 GO:0008121 GO:0009060 GO:0016020 GO:0016491 GO:0022857 GO:0034551 GO:0045275 GO:0045333 GO:0055085 GO:0099617 GO:1902600
physicalEntity	[EntityWithAccessionedSequence:R-SCE-9866111] QCR7 [mitochondrial inner membrane] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-164287] QCR7 [mitochondrial inner membrane] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12724191] UCSC:P00128 QCR7 [ReferenceDNASequence:12028215] NCBI Gene:852142 QCR7 [ReferenceDNASequence:11944122] Monarch:852142 QCR7 [ReferenceDNASequence:11857832] KEGG:sce:YDR529C QCR7 [ReferenceDNASequence:11314333] BioGPS Gene:852142 QCR7
referenceTranscript	[ReferenceRNASequence:12500240] RefSeq:NM_001180837.1 QCR7
schemaClass	ReferenceGeneProduct
secondaryIdentifier	QCR7_YEAST D6VTF0
sequenceLength	127
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P00128
url	http://purl.uniprot.org/uniprot/P00128

Referrals

(interactor)	[UndirectedInteraction:11306545] UniProt:P00128 <-> UniProt:P18239 (IntAct) [UndirectedInteraction:11306543] UniProt:P00128 <-> UniProt:P07143 (IntAct) [UndirectedInteraction:11306541] UniProt:P00128 <-> UniProt:Q01519 (IntAct) [UndirectedInteraction:11268873] UniProt:P07257 <-> UniProt:P00128 (IntAct) [UndirectedInteraction:11220667] UniProt:P07256 <-> UniProt:P00128 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-SCE-9866111] QCR7 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-SCE-164287] QCR7 [mitochondrial inner membrane]