UniProt:O95816 BAG2

chain
  • initiator methionine:1
  • chain:2-211
checksum CAF631F4578FCCA3
comment
  • FUNCTION Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).SUBUNIT Binds to the ATPase domain of HSP/HSC70 chaperones (PubMed:9873016). May interact with NWD1 (PubMed:24681825). Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8 (PubMed:24318877). May interact with DNJC9; the interaction seems to be histone-dependent (PubMed:33857403).
crossReference
databaseName UniProt
dbId 50673
description
  • recommendedName: BAG family molecular chaperone regulator 2 shortName: BAG-2 alternativeName: Bcl-2-associated athanogene 2
displayName UniProt:O95816 BAG2
geneName
  • BAG2
identifier O95816
isSequenceChanged false
keyword
  • Acetylation
  • Alternative splicing
  • Chaperone
  • Coiled coil
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • BAG2
otherIdentifier
  • 11742904_s_at
  • 11748602_a_at
  • 17009853
  • 209406_PM_at
  • 209406_at
  • 230750_PM_at
  • 230750_at
  • 2911373
  • 2911374
  • 2911382
  • 2911384
  • 2911385
  • 2911386
  • 2911390
  • 2911392
  • 2911394
  • 2911396
  • 2911397
  • 2911398
  • 2911399
  • 2911400
  • 2911402
  • 35291_at
  • 8120402
  • 9532
  • A_14_P124996
  • A_23_P356554
  • GE55675
  • GO:0000774
  • GO:0005515
  • GO:0005829
  • GO:0005874
  • GO:0006457
  • GO:0008092
  • GO:0010954
  • GO:0019538
  • GO:0030424
  • GO:0030425
  • GO:0031072
  • GO:0031397
  • GO:0031625
  • GO:0042802
  • GO:0044325
  • GO:0045862
  • GO:0048156
  • GO:0050821
  • GO:0051087
  • GO:0098772
  • GO:0101031
  • GO:1901588
  • GO:1901800
  • HMNXSV003024752
  • Hs.94769.2.A1_3p_at
  • TC06000684.hg
  • g4322819_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BAG2_HUMAN
  • B4DXE2
  • Q08AS9
  • Q6FID0
sequenceLength 211
species [Species:48887] Homo sapiens
stId uniprot:O95816
url http://purl.uniprot.org/uniprot/O95816

Referrals

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