UniProt:O95677 EYA4

chain
  • chain:1-639
checksum CC59A8FB1527A0EC
comment
  • FUNCTION Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateCOFACTOR Binds 1 Mg(2+) ion per subunit.SUBUNIT Interacts with SIX3; translocates EYA4 from the cytoplasm to the nucleus and promotes activation of their target genes.SUBCELLULAR LOCATION Highly expressed in heart and skeletal muscle.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the HAD-like hydrolase superfamily. EYA family.
crossReference
databaseName UniProt
dbId 54552
description
  • recommendedName: fullName evidence="14"Protein phosphatase EYA4 ecNumber evidence="2"3.1.3.48 alternativeName: Eyes absent homolog 4
displayName UniProt:O95677 EYA4
geneName
  • EYA4
identifier O95677
isSequenceChanged false
keyword
  • Acetylation
  • Activator
  • Alternative splicing
  • Cardiomyopathy
  • Chromatin regulator
  • Cytoplasm
  • Deafness
  • Developmental protein
  • Disease variant
  • DNA damage
  • DNA repair
  • Hydrolase
  • Isopeptide bond
  • Magnesium
  • Metal-binding
  • Non-syndromic deafness
  • Nucleus
  • Phosphoprotein
  • Protein phosphatase
  • Proteomics identification
  • Reference proteome
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • EYA4
otherIdentifier
  • 11732793_a_at
  • 11732794_a_at
  • 11741541_a_at
  • 1561088_PM_at
  • 1561088_at
  • 17012721
  • 2070
  • 207327_PM_at
  • 207327_at
  • 238877_PM_at
  • 238877_at
  • 2926324
  • 2926325
  • 2926326
  • 2926327
  • 2926329
  • 2926330
  • 2926332
  • 2926333
  • 2926340
  • 2926344
  • 2926347
  • 2926357
  • 2926359
  • 2926362
  • 2926363
  • 2926364
  • 2926365
  • 2926366
  • 2926367
  • 2926368
  • 2926369
  • 2926371
  • 2926372
  • 2926373
  • 2926374
  • 2926378
  • 2926380
  • 2926382
  • 2926383
  • 2926384
  • 2926385
  • 2926386
  • 2926387
  • 2926388
  • 2926389
  • 2926390
  • 2926391
  • 2926392
  • 2926393
  • 2926394
  • 2926395
  • 2926396
  • 2926397
  • 34631_at
  • 64963_at
  • 8122150
  • 85598_at
  • A_14_P103124
  • A_23_P145507
  • A_32_P219620
  • A_33_P3252281
  • GE805112
  • GE81348
  • GO:0003824
  • GO:0004721
  • GO:0004725
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0006281
  • GO:0006325
  • GO:0006974
  • GO:0007275
  • GO:0007601
  • GO:0009653
  • GO:0016787
  • GO:0030154
  • GO:0045739
  • GO:0046872
  • GO:0048839
  • GO:0048856
  • GO:0050877
  • GO:0140096
  • GO:2001240
  • HMNXSV003031313
  • HMNXSV003040692
  • Hs.102408.0.A1_3p_at
  • Hs2.374689.1.S1_3p_at
  • ILMN_1671844
  • ILMN_1693319
  • ILMN_2324734
  • PH_hs_0022251
  • TC06000999.hg
  • TC06003060.hg
  • TC06003061.hg
  • g4758319_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • EYA4_HUMAN
  • B7Z7F7
  • O95464
  • O95679
  • Q8IW39
  • Q9NTR7
sequenceLength 639
species [Species:48887] Homo sapiens
stId uniprot:O95677
url http://purl.uniprot.org/uniprot/O95677
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