UniProt:O95497 VNN1

chain
  • signal peptide:1-21
  • chain:22-491
  • propeptide:492-513
checksum 018D2417C12E403F
comment
  • FUNCTION Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.CATALYTIC ACTIVITY (R)-pantetheine + H2O = cysteamine + (R)-pantothenateSUBUNIT Monomer.SUBCELLULAR LOCATION Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.INDUCTION By Th17/Th1 type cytokines, but not by Th2-type.SIMILARITY Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
crossReference
databaseName UniProt
dbId 67218
description
  • recommendedName: Pantetheinase ecNumber evidence="4 11"3.5.1.92 alternativeName: Pantetheine hydrolase alternativeName: Tiff66 alternativeName: Vascular non-inflammatory molecule 1 shortName: Vanin-1
displayName UniProt:O95497 VNN1
geneName
  • VNN1
identifier O95497
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • Glycoprotein
  • GPI-anchor
  • Hydrolase
  • Lipoprotein
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Signal
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • VNN1
otherIdentifier
  • 11729842_at
  • 11729843_s_at
  • 11729844_at
  • 11729845_at
  • 11758233_s_at
  • 11758361_s_at
  • 1558549_3p_s_at
  • 1558549_PM_s_at
  • 1558549_s_at
  • 17023707
  • 205844_PM_at
  • 205844_at
  • 2974591
  • 2974593
  • 2974594
  • 2974595
  • 2974596
  • 2974597
  • 2974598
  • 2974599
  • 2974600
  • 2974601
  • 2974602
  • 2974603
  • 2974604
  • 2974605
  • 37526_at
  • 52189_s_at
  • 52192_r_at
  • 8129618
  • 8876
  • A_23_P255345
  • A_24_P337700
  • A_33_P3399571
  • GE55222
  • GE628273
  • GO:0002376
  • GO:0002526
  • GO:0002544
  • GO:0005576
  • GO:0005886
  • GO:0006575
  • GO:0006790
  • GO:0006954
  • GO:0006979
  • GO:0015938
  • GO:0015939
  • GO:0016020
  • GO:0016787
  • GO:0016811
  • GO:0017159
  • GO:0033089
  • GO:0035577
  • GO:0045087
  • GO:0055086
  • GO:0098542
  • GO:0098552
  • GO:0098609
  • GO:1902177
  • HMNXSV003006980
  • Hs2.379831.1.S1_3p_s_at
  • ILMN_1674574
  • PH_hs_0001141
  • TC06002119.hg
  • g4759311_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • VNN1_HUMAN
  • A8K310
  • Q4JFW6
  • Q4VAS7
  • Q4VAS8
  • Q4VAS9
  • Q9UF16
  • Q9UJF4
sequenceLength 513
species [Species:48887] Homo sapiens
stId uniprot:O95497
url http://purl.uniprot.org/uniprot/O95497
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