UniProt:O95429 BAG4

chain
  • chain:1-457
checksum B89D59E8118684A3
comment
  • FUNCTION Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.SUBUNIT Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12. Interacts with PRKN.INTERACTION Ubiquitous.
crossReference
databaseName UniProt
dbId 50677
description
  • recommendedName: BAG family molecular chaperone regulator 4 shortName: BAG-4 alternativeName: Bcl-2-associated athanogene 4 alternativeName: Silencer of death domains
displayName UniProt:O95429 BAG4
geneName
  • BAG4
  • SODD
identifier O95429
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Chaperone
  • Cytoplasm
  • Methylation
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • BAG4
otherIdentifier
  • 11743422_a_at
  • 11747805_a_at
  • 11759495_at
  • 17068003
  • 219624_PM_at
  • 219624_at
  • 222909_PM_s_at
  • 222909_s_at
  • 228189_PM_at
  • 228189_at
  • 2518866
  • 3094495
  • 3094496
  • 3094502
  • 3094503
  • 3094504
  • 3094505
  • 3094506
  • 3094507
  • 3094508
  • 3094509
  • 47063_at
  • 48414_at
  • 55982_at
  • 8145914
  • 9530
  • A_14_P113907
  • A_23_P146217
  • A_24_P930926
  • GE61962
  • GE87904
  • GO:0000774
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0005886
  • GO:0006457
  • GO:0010763
  • GO:0016020
  • GO:0030838
  • GO:0031625
  • GO:0043066
  • GO:0044877
  • GO:0045785
  • GO:0050821
  • GO:0051087
  • GO:0051496
  • GO:0051897
  • GO:0071356
  • GO:0071364
  • GO:0072659
  • GO:0090367
  • GO:0097178
  • GO:0098772
  • GO:1903215
  • HMNXSV003046383
  • Hs.7859.0.A1_3p_at
  • ILMN_1727996
  • ILMN_2221014
  • PH_hs_0011517
  • TC08000287.hg
  • g4160013_3p_a_at
  • g6631074_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BAG4_HUMAN
  • B4E217
  • O95818
sequenceLength 457
species [Species:48887] Homo sapiens
stId uniprot:O95429
url http://purl.uniprot.org/uniprot/O95429

Referrals

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