Reactome | UniProt:O95415 BRI3

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UniProt:O95415 BRI3 Show undefined attributes

chain	chain:1-125
checksum	ABBFADD00E91C52C
comment	FUNCTION Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055).SUBUNIT Interacts with BRI3BP (PubMed:11860200, PubMed:30983867). Interacts with MGAT1 and IFITM3 (PubMed:30983867).SUBUNIT Interacts with BRI3BP, MGAT1 and IFITM3; the interactions are weaker than with isoform 1.INTERACTION Co-localizes with MGAT1 and IFITM3 at the perinuclear region.SUBCELLULAR LOCATION Diffuse localization in the cytoplasm and nucleus.ALTERNATIVE PRODUCTS Up-regulated during TNF-mediated inflammation and immunity (By similarity). Up-regulated by beta-catenin and TCF4 (PubMed:20538055).SIMILARITY Belongs to the BRI3 family.
crossReference	[DatabaseIdentifier:12350471] RefSeq:NP_056194.1 [DatabaseIdentifier:12350472] RefSeq:NP_001152963.1 [DatabaseIdentifier:12294867] Pharos - Targets:O95415 [DatabaseIdentifier:12257448] PRO:O95415 [DatabaseIdentifier:12134705] OpenTargets:ENSG00000164713 [DatabaseIdentifier:11850003] HPA:ENSG00000164713-BRI3 [DatabaseIdentifier:11797036] GeneCards:BRI3 [DatabaseIdentifier:11682669] ENSEMBL:ENST00000297290 [DatabaseIdentifier:11682670] ENSEMBL:ENST00000539286 [DatabaseIdentifier:11559970] ENSEMBL:ENSP00000440936 [DatabaseIdentifier:11559971] ENSEMBL:ENSP00000297290 [DatabaseIdentifier:11464848] ENSEMBL:ENSG00000164713
databaseName	UniProt
dbId	50824
description	recommendedName: fullName evidence="8"Membrane protein BRI3 alternativeName: fullName evidence="10"Brain protein I3 alternativeName: pRGR2
displayName	UniProt:O95415 BRI3
geneName	BRI3
identifier	O95415
isSequenceChanged	false
keyword	Alternative splicing Cytoplasm Lysosome Membrane Nucleus Proteomics identification Reference proteome Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	BRI3
otherIdentifier	11715342_at 11719169_s_at 17048727 17048738 223376_PM_s_at 223376_s_at 2348851 239821_PM_at 239821_at 25798 3014231 3014232 3014238 3014239 3014240 3014242 3014243 3014244 3014245 3014246 3014247 3014252 3014253 3014254 3014255 3014256 3014257 3014258 3014259 3014260 3014290 3014292 3014293 64610_at 65685_at 8134454 8134460 A_21_P0000022 A_23_P122915 A_24_P76512 GE82004 GO:0005515 GO:0005634 GO:0005737 GO:0005764 GO:0005765 GO:0005886 GO:0016020 GO:0035577 GO:0042802 GO:0048471 HMNXSV003015888 HMNXSV003055850 Hs.188504.0.A1_3p_at ILMN_1653352 ILMN_1781580 PH_hs_0027513 TC07000584.hg TC07000585.hg TC07000586.hg g13094234_3p_at p25483
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6806260] BRI3 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6799127] BRI3 [azurophil granule membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12734082] UCSC:O95415 BRI3 [ReferenceDNASequence:12118850] OMIM:615628 BRI3 [ReferenceDNASequence:12042974] NCBI Gene:25798 BRI3 [ReferenceDNASequence:11958881] Monarch:25798 BRI3 [ReferenceDNASequence:11871196] KEGG:hsa:25798 BRI3 [ReferenceDNASequence:11828752] HGNC:1109 BRI3 [ReferenceDNASequence:11435831] dbSNP Gene:25798 BRI3 [ReferenceDNASequence:11426445] CTD Gene:25798 BRI3 [ReferenceDNASequence:11398939] COSMIC - genes:BRI3 BRI3 [ReferenceDNASequence:11329092] BioGPS Gene:25798 BRI3 [ReferenceDNASequence:ensembl:ENSG00000164713] ENSEMBL:ENSG00000164713 BRI3
referenceTranscript	[ReferenceRNASequence:12532327] RefSeq:NM_001159491.2 BRI3 [ReferenceRNASequence:12532328] RefSeq:NM_015379.5 BRI3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	BRI3_HUMAN D6W5R8 F5GXW6 Q8WV52 Q9UIC6
sequenceLength	125
species	[Species:48887] Homo sapiens
stId	uniprot:O95415
url	http://purl.uniprot.org/uniprot/O95415

Referrals

(interactor)	[UndirectedInteraction:11276945] UniProt:P26572 <-> UniProt:O95415 (IntAct) [UndirectedInteraction:11155785] UniProt:Q01628 <-> UniProt:O95415 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6806260] BRI3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-6799127] BRI3 [azurophil granule membrane]