UniProt:O95391 SLU7

chain
  • initiator methionine:1
  • chain:2-586
checksum 237B8C8014EEAB6E
comment
  • FUNCTION Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154). Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.SUBUNIT Component of pre-catalytic, catalytic and post-catalytic spliceosomes (PubMed:10197984, PubMed:28502770, PubMed:30705154). Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I (PubMed:10197984).INTERACTION Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.DOMAIN The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.SIMILARITY Belongs to the SLU7 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 248542
description
  • recommendedName: Pre-mRNA-splicing factor SLU7 shortName: hSlu7
displayName UniProt:O95391 SLU7
geneName
  • SLU7
identifier O95391
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cytoplasm
  • Isopeptide bond
  • Metal-binding
  • mRNA processing
  • mRNA splicing
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Spliceosome
  • Ubl conjugation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • SLU7
otherIdentifier
  • 10569
  • 11724469_at
  • 11757348_s_at
  • 17002402
  • 227990_PM_at
  • 227990_at
  • 231718_PM_at
  • 231718_at
  • 2884659
  • 2884660
  • 2884661
  • 2884663
  • 2884664
  • 2884665
  • 2884666
  • 2884667
  • 2884668
  • 2884669
  • 2884671
  • 2884672
  • 2884673
  • 2884674
  • 2884675
  • 2884676
  • 2884678
  • 2884679
  • 2884680
  • 2884681
  • 2884682
  • 2884683
  • 2884684
  • 2884685
  • 2884686
  • 2884687
  • 2884688
  • 43358_r_at
  • 48520_at
  • 52217_s_at
  • 52219_r_at
  • 57018_at
  • 8115606
  • A_23_P110704
  • A_24_P174824
  • A_24_P377328
  • GE79256
  • GE88616
  • GO:0000375
  • GO:0000380
  • GO:0000386
  • GO:0000389
  • GO:0000398
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005681
  • GO:0005737
  • GO:0005829
  • GO:0006397
  • GO:0006886
  • GO:0008270
  • GO:0008380
  • GO:0016020
  • GO:0016071
  • GO:0016607
  • GO:0030532
  • GO:0030628
  • GO:0034605
  • GO:0046872
  • GO:0065003
  • GO:0071013
  • HMNXSV003044116
  • Hs.76325.0.A1_3p_at
  • Hs.76325.2.A1_3p_at
  • ILMN_1685369
  • PH_hs_0020409
  • TC05002010.hg
  • TC05003330.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SLU7_HUMAN
  • D3DQK2
  • Q3LUJ0
  • Q3LUJ1
  • Q6RXQ5
  • Q96FM9
sequenceLength 586
species [Species:48887] Homo sapiens
stId uniprot:O95391
url http://purl.uniprot.org/uniprot/O95391

Referrals

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