Reactome | UniProt:O95347 SMC2

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UniProt:O95347 SMC2 Show undefined attributes

chain	chain:1-1197
checksum	15EBB56B31FC1364
comment	FUNCTION Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.SUBUNIT Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Interacts with BRD4 (isoform B), leading to insulate chromatin from DNA damage response pathway.INTERACTION In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.ALTERNATIVE PRODUCTS The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.SIMILARITY Belongs to the SMC family. SMC2 subfamily.
crossReference	[DatabaseIdentifier:11463303] ENSEMBL:ENSG00000136824 [DatabaseIdentifier:11557738] ENSEMBL:ENSP00000363925 [DatabaseIdentifier:11557736] ENSEMBL:ENSP00000363919 [DatabaseIdentifier:11557737] ENSEMBL:ENSP00000286398 [DatabaseIdentifier:11680436] ENSEMBL:ENST00000374793 [DatabaseIdentifier:11680435] ENSEMBL:ENST00000286398 [DatabaseIdentifier:11680437] ENSEMBL:ENST00000374787 [DatabaseIdentifier:11796051] GeneCards:SMC2 [DatabaseIdentifier:11811779] GlyGen:O95347 [DatabaseIdentifier:11849019] HPA:ENSG00000136824-SMC2 [DatabaseIdentifier:12133711] OpenTargets:ENSG00000136824 [DatabaseIdentifier:12227826] PDB:4U4P [DatabaseIdentifier:12139194] PDB:9F5W [DatabaseIdentifier:12256132] PRO:O95347 [DatabaseIdentifier:12293877] Pharos - Targets:O95347 [DatabaseIdentifier:12347379] RefSeq:XP_054217747.1 [DatabaseIdentifier:12347377] RefSeq:XP_011516451.1 [DatabaseIdentifier:12347371] RefSeq:XP_016869695.1 [DatabaseIdentifier:12347380] RefSeq:XP_054217758.1 [DatabaseIdentifier:12347382] RefSeq:XP_054217745.1 [DatabaseIdentifier:12347378] RefSeq:XP_054217746.1 [DatabaseIdentifier:12347383] RefSeq:XP_011516455.1 [DatabaseIdentifier:12347381] RefSeq:XP_054217744.1 [DatabaseIdentifier:12347385] RefSeq:XP_054217743.1 [DatabaseIdentifier:12347374] RefSeq:NP_001252531.1 [DatabaseIdentifier:12347376] RefSeq:XP_011516450.1 [DatabaseIdentifier:12347375] RefSeq:NP_001036015.1 [DatabaseIdentifier:12347369] RefSeq:NP_006435.2 [DatabaseIdentifier:12347373] RefSeq:NP_001036016.1 [DatabaseIdentifier:12347384] RefSeq:XP_054217742.1 [DatabaseIdentifier:12347370] RefSeq:XP_006716996.1 [DatabaseIdentifier:12347372] RefSeq:XP_016869697.1
databaseName	UniProt
dbId	101781
description	recommendedName: Structural maintenance of chromosomes protein 2 shortName: SMC protein 2 shortName: SMC-2 alternativeName: Chromosome-associated protein E shortName: hCAP-E alternativeName: XCAP-E homolog
displayName	UniProt:O95347 SMC2
geneName	SMC2 CAPE SMC2L1 PRO0324
identifier	O95347
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing ATP-binding Cell cycle Cell division Chromosome Coiled coil Cytoplasm DNA condensation Mitosis Nucleotide-binding Nucleus Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SMC2
otherIdentifier	10592 11736527_a_at 11736528_a_at 11740118_a_at 11740119_x_at 11740120_a_at 11744868_a_at 11745424_a_at 1559444_PM_at 1559444_at 17087716 204240_PM_s_at 204240_s_at 213253_PM_at 213253_at 3182782 3182783 3182784 3182785 3182786 3182787 3182788 3182789 3182790 3182792 3182793 3182794 3182795 3182796 3182797 3182798 3182799 3182800 3182801 3182802 3182803 3182804 3182806 3182807 3182809 3182810 3182811 3182812 3182814 3182815 3182817 3182818 3182819 3182820 3182821 3182824 3182825 3182826 3182827 3182828 3182829 3182830 3182831 37502_at 62730_at 62760_at 79366_at 8156982 A_14_P104087 A_14_P139774 A_23_P60271 A_33_P3357322 A_33_P3378334 GE55807 GE902034 GO:0000166 GO:0000228 GO:0000280 GO:0000785 GO:0000793 GO:0000794 GO:0000796 GO:0003677 GO:0003682 GO:0003697 GO:0005515 GO:0005524 GO:0005634 GO:0005654 GO:0005694 GO:0005730 GO:0005737 GO:0005829 GO:0007076 GO:0010032 GO:0016787 GO:0016887 GO:0022414 GO:0030261 GO:0045132 GO:0051276 GO:0051301 GO:0051383 GO:0051984 GO:0070062 GO:0098813 GO:1905820 GO:1905821 HMNXSV003009056 Hs.119023.2.S1_3p_at Hs2.376925.1.S1_3p_at ILMN_1748923 ILMN_2296422 ILMN_2411190 PH_hs_0006569 TC09000526.hg g5453590_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2517875] SMC2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1629792] SMC2 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000136824] ENSEMBL:ENSG00000136824 SMC2 [ReferenceDNASequence:12732914] UCSC:O95347 SMC2 [ReferenceDNASequence:11327683] BioGPS Gene:10592 SMC2 [ReferenceDNASequence:11398744] COSMIC - genes:SMC2 SMC2 [ReferenceDNASequence:11425173] CTD Gene:10592 SMC2 [ReferenceDNASequence:11435602] dbSNP Gene:10592 SMC2 [ReferenceDNASequence:11827756] HGNC:14011 SMC2 [ReferenceDNASequence:11869904] KEGG:hsa:10592 SMC2 [ReferenceDNASequence:11957472] Monarch:10592 SMC2 [ReferenceDNASequence:12041565] NCBI Gene:10592 SMC2 [ReferenceDNASequence:12117952] OMIM:605576 SMC2
referenceTranscript	[ReferenceRNASequence:12529243] RefSeq:XM_011518153.2 SMC2 [ReferenceRNASequence:12529239] RefSeq:XM_054361770.1 SMC2 [ReferenceRNASequence:12529228] RefSeq:XM_011518148.3 SMC2 [ReferenceRNASequence:12529238] RefSeq:XM_054361771.1 SMC2 [ReferenceRNASequence:12529227] RefSeq:XM_011518149.4 SMC2 [ReferenceRNASequence:12529236] RefSeq:NM_001042550.2 SMC2 [ReferenceRNASequence:12529233] RefSeq:NM_006444.3 SMC2 [ReferenceRNASequence:12529241] RefSeq:XM_054361772.1 SMC2 [ReferenceRNASequence:12529230] RefSeq:XM_017014208.2 SMC2 [ReferenceRNASequence:12529240] RefSeq:XM_006716933.4 SMC2 [ReferenceRNASequence:12529237] RefSeq:XM_054361769.1 SMC2 [ReferenceRNASequence:12529231] RefSeq:XM_017014206.2 SMC2 [ReferenceRNASequence:12529229] RefSeq:NM_001042551.2 SMC2 [ReferenceRNASequence:12529232] RefSeq:NM_001265602.2 SMC2 [ReferenceRNASequence:12529235] RefSeq:XM_054361767.1 SMC2 [ReferenceRNASequence:12529242] RefSeq:XM_054361783.1 SMC2 [ReferenceRNASequence:12529234] RefSeq:XM_054361768.1 SMC2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SMC2_HUMAN Q6IEE0 Q9P1P2
sequenceLength	1197
species	[Species:48887] Homo sapiens
stId	uniprot:O95347
url	http://purl.uniprot.org/uniprot/O95347

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2517875] SMC2 [cytosol] [EntityWithAccessionedSequence:R-HSA-1629792] SMC2 [nucleoplasm]
(interactor)	[UndirectedInteraction:11208211] UniProt:P01106 <-> UniProt:O95347 (IntAct)