UniProt:O95298 NDUFC2

chain
  • chain:1-119
checksum 9A47DEE33DC9244D
comment
  • FUNCTION Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SUBUNIT Complex I is composed of 45 different subunits. Interacts with TMEM242 (PubMed:33753518).SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I NDUFC2 subunit family.
crossReference
databaseName UniProt
dbId 59861
description
  • recommendedName: fullName evidence="10"NADH dehydrogenase [ubiquinone] 1 subunit C2 alternativeName: Complex I-B14.5b shortName: CI-B14.5b alternativeName: Human lung cancer oncogene 1 protein shortName: HLC-1 alternativeName: NADH-ubiquinone oxidoreductase subunit B14.5b
displayName UniProt:O95298 NDUFC2
geneName
  • NDUFC2
  • HLC1
identifier O95298
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Disease variant
  • Electron transport
  • Membrane
  • Mitochondrion
  • Mitochondrion inner membrane
  • Primary mitochondrial disease
  • Proteomics identification
  • Reference proteome
  • Respiratory chain
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • NDUFC2
otherIdentifier
  • 11717626_a_at
  • 11748433_x_at
  • 11755526_x_at
  • 206936_PM_x_at
  • 206936_x_at
  • 218101_PM_s_at
  • 218101_s_at
  • 222521_3p_x_at
  • 222521_PM_x_at
  • 222521_x_at
  • 3383144
  • 3383145
  • 3383146
  • 3383147
  • 3383148
  • 3383149
  • 3383150
  • 3383152
  • 3383153
  • 3383158
  • 3383159
  • 4718
  • 48417_r_at
  • 49576_f_at
  • 53749_at
  • 7950644
  • 89456_at
  • A_23_P2152
  • A_24_P364236
  • A_33_P3336652
  • GE81407
  • GO:0005515
  • GO:0005737
  • GO:0005739
  • GO:0005743
  • GO:0005886
  • GO:0006091
  • GO:0006120
  • GO:0007005
  • GO:0008137
  • GO:0009060
  • GO:0010918
  • GO:0016020
  • GO:0016491
  • GO:0032981
  • GO:0035577
  • GO:0042776
  • GO:0045271
  • GO:0055085
  • GO:0055086
  • GO:0065003
  • GO:1901135
  • GO:1901223
  • GO:1902600
  • GO:1903427
  • GO:2001171
  • HMNXSV003057011
  • Hs.193313.0.A2_3p_x_at
  • ILMN_1694274
  • PH_hs_0019446
  • g11641234_3p_s_at
  • g4758783_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NDUC2_HUMAN
  • E9PNU8
  • E9PRB2
  • Q549M5
  • Q6FIH8
  • Q9UBJ9
sequenceLength 119
species [Species:48887] Homo sapiens
stId uniprot:O95298
url http://purl.uniprot.org/uniprot/O95298
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