UniProt:O94822 LTN1

chain
  • chain:1-1766
checksum 9312CB2283C50AEE
comment
  • FUNCTION E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875, PubMed:28757607). Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase LTN1, TCF25 and NEMF associated with the 60S ribosomal subunit (PubMed:25578875). The complex probably also contains VCP/p97 and its ubiquitin-binding cofactors (By similarity).INTERACTION Autoubiquitinated.SIMILARITY Belongs to the LTN1 family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.
crossReference
databaseName UniProt
dbId 68016
description
  • recommendedName: E3 ubiquitin-protein ligase listerin ecNumber evidence="16"2.3.2.27 alternativeName: RING finger protein 160 alternativeName: fullName evidence="15"RING-type E3 ubiquitin transferase listerin alternativeName: Zinc finger protein 294
displayName UniProt:O94822 LTN1
geneName
  • LTN1
  • C21orf10
  • C21orf98
  • KIAA0714
  • RNF160
  • ZNF294
  • HSPC087
identifier O94822
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cytoplasm
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transferase
  • Ubl conjugation
  • Ubl conjugation pathway
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • LTN1
otherIdentifier
  • 11724925_at
  • 11724926_at
  • 16924668
  • 215596_PM_s_at
  • 215596_s_at
  • 233818_PM_at
  • 233818_at
  • 233819_PM_s_at
  • 233819_s_at
  • 26046
  • 39005_s_at
  • 3927956
  • 3927957
  • 3927958
  • 3927959
  • 3927960
  • 3927961
  • 3927962
  • 3927963
  • 3927964
  • 3927966
  • 3927967
  • 3927968
  • 3927973
  • 3927974
  • 3927975
  • 3927977
  • 3927978
  • 3927979
  • 3927980
  • 3927981
  • 3927982
  • 3927984
  • 3927985
  • 3927986
  • 3927987
  • 3927988
  • 3927989
  • 3927990
  • 3927991
  • 3927992
  • 3927993
  • 3927994
  • 3927995
  • 3927996
  • 3927997
  • 3927999
  • 3928000
  • 3928001
  • 3928002
  • 3928003
  • 3928004
  • 3928005
  • 3928006
  • 3928008
  • 3928009
  • 3928010
  • 3928011
  • 3928012
  • 3928013
  • 3928014
  • 3928015
  • 3928019
  • 3928020
  • 3928021
  • 8069711
  • A_32_P115505
  • A_33_P3304865
  • GE53438
  • GO:0003824
  • GO:0004842
  • GO:0005515
  • GO:0005737
  • GO:0005829
  • GO:0005840
  • GO:0008270
  • GO:0016567
  • GO:0016740
  • GO:0022626
  • GO:0030163
  • GO:0043023
  • GO:0043161
  • GO:0046872
  • GO:0051865
  • GO:0061630
  • GO:0072344
  • GO:0140096
  • GO:1990112
  • GO:1990116
  • HMNXSV003000209
  • HMNXSV003043140
  • Hs.288773.1.S1_3p_a_at
  • Hs.288773.2.S1_3p_a_at
  • ILMN_1760360
  • ILMN_2077504
  • PH_hs_0014996
  • TC21000351.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • LTN1_HUMAN
  • A6NL41
  • A7E2D0
  • B2RTS0
  • C9J7U3
  • J3KPL4
  • Q05C47
  • Q9H8M4
  • Q9NUY5
  • Q9P0E9
sequenceLength 1766
species [Species:48887] Homo sapiens
stId uniprot:O94822
url http://purl.uniprot.org/uniprot/O94822

Referrals

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