Reactome | UniProt:O88410 Cxcr3

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UniProt:O88410 Cxcr3 Show undefined attributes

chain	chain:1-367
checksum	EF0348A8358AD951
comment	FUNCTION Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Binds to CCL21. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling.SUBUNIT Homomer. Forms heteromers with ACKR4 (By similarity). Interacts with PF4/CXCL4 (By similarity).SUBCELLULAR LOCATION Expresses in lymphoid organs and Th1 cells.PTM Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding.PTM N-glycosylated.SIMILARITY Belongs to the G-protein coupled receptor 1 family.
crossReference	[DatabaseIdentifier:12816189] ZINC target:O88410 [DatabaseIdentifier:12812806] ZINC - Substances:CXCR3_MOUSE [DatabaseIdentifier:12808418] ZINC - Predictions - Purchasable:CXCR3_MOUSE [DatabaseIdentifier:12368668] RefSeq:NP_034040.1 [DatabaseIdentifier:12265107] PRO:O88410 [DatabaseIdentifier:11935092] MGI:1277207 [DatabaseIdentifier:11803320] GlyGen:O88410 [DatabaseIdentifier:11692910] ENSEMBL:ENSMUST00000056614 [DatabaseIdentifier:11570211] ENSEMBL:ENSMUSP00000052444 [DatabaseIdentifier:11472536] ENSEMBL:ENSMUSG00000050232
databaseName	UniProt
dbId	86873
description	recommendedName: C-X-C chemokine receptor type 3 shortName: CXC-R3 shortName: CXCR-3 alternativeName: Interferon-inducible protein 10 receptor shortName: IP-10 receptor cdAntigenNameCD183/cdAntigenName
displayName	UniProt:O88410 Cxcr3
geneName	Cxcr3 Cmkar3
identifier	O88410
isSequenceChanged	false
keyword	Angiogenesis Cell membrane Chemotaxis Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Sulfation Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
moleculeType	Protein
name	Cxcr3
otherIdentifier	10606058 12766 1449925_at 17543625 4557221 4696121 5165244 94173_at A_51_P319022 GE1499991 GO:0001525 GO:0002376 GO:0002685 GO:0004930 GO:0004950 GO:0005886 GO:0006935 GO:0006954 GO:0006955 GO:0007165 GO:0007166 GO:0007186 GO:0007204 GO:0008284 GO:0009897 GO:0009986 GO:0010818 GO:0016020 GO:0016493 GO:0016494 GO:0019722 GO:0019956 GO:0019957 GO:0019958 GO:0030155 GO:0038023 GO:0045766 GO:0048870 GO:0050921 GO:0051281 GO:0060326 GO:0070098 GO:1900118 ILMN_2658786 mMC016480
physicalEntity	[EntityWithAccessionedSequence:R-MMU-9943756] Cxcr3 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2980699] Cxcr3 [plasma membrane] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12738353] UCSC:O88410 Cxcr3 [ReferenceDNASequence:12051522] NCBI Gene:12766 Cxcr3 [ReferenceDNASequence:11967429] Monarch:12766 Cxcr3 [ReferenceDNASequence:11878633] KEGG:mmu:12766 Cxcr3 [ReferenceDNASequence:11337640] BioGPS Gene:12766 Cxcr3
referenceTranscript	[ReferenceRNASequence:12550488] RefSeq:NM_009910.3 Cxcr3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CXCR3_MOUSE Q4V9Y6 Q9QWN6
sequenceLength	367
species	[Species:48892] Mus musculus
stId	uniprot:O88410
url	http://purl.uniprot.org/uniprot/O88410

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