UniProt:O76324 dco

chain
  • chain:1-440
checksum 0B67B83E44213902
comment
  • FUNCTION Serine/threonine-protein kinase which is involved in the circadian rhythm pathway, viability and planar cell polarity (PubMed:10556065, PubMed:26082158, PubMed:32750048, PubMed:9674430, PubMed:9674431). In the circadian rhythm pathway, phosphorylates the clock gene period (per) and targets it for degradation in the absence of timeless (tim), thus contributing to production of the circadian oscillations of the clock genes (PubMed:26082158, PubMed:32750048, PubMed:9674430, PubMed:9674431). Together with CkIalpha, regulates processing of ci by phosphorylating it, which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase (PubMed:16326393). Involved in the inhibition of apoptosis during cell proliferation and growth arrest in imaginal disks (PubMed:10556065). Also functions in planar cell polarity (PubMed:32750048).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Forms a complex with per (PubMed:9674431). Interacts with Dlish (PubMed:27692068). Interacts (via nuclear localization signal) with Bdbt (PubMed:26082158).SUBCELLULAR LOCATION Detected in the nucleus and cytoplasm of the small and large lateral neurons (sLNv and lLNv).TISSUE SPECIFICITY Detected in the head (at protein level) (PubMed:26082158). Expressed in photoreceptor cells of the eyes as well as in the region situated between the optic lobe and the central brain (PubMed:10556065).SIMILARITY Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
crossReference
databaseName UniProt
dbId 88842
description
  • recommendedName: Discs overgrown protein kinase ecNumber: 2.7.11.1 alternativeName: Protein double-time
displayName UniProt:O76324 dco
geneName
  • dco
  • dbt
  • CG2048
identifier O76324
isSequenceChanged false
keyword
  • ATP-binding
  • Biological rhythms
  • Cytoplasm
  • Kinase
  • Nucleotide-binding
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Serine/threonine-protein kinase
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • dco
otherIdentifier
  • 143635_at
  • 153528_at
  • 1624447_s_at
  • 1638726_at
  • 43673
  • GO:0000166
  • GO:0001933
  • GO:0003824
  • GO:0004672
  • GO:0004674
  • GO:0005515
  • GO:0005524
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005829
  • GO:0005886
  • GO:0006468
  • GO:0006897
  • GO:0007154
  • GO:0007165
  • GO:0007446
  • GO:0007555
  • GO:0007623
  • GO:0016192
  • GO:0016301
  • GO:0016310
  • GO:0016740
  • GO:0030177
  • GO:0030307
  • GO:0030838
  • GO:0032436
  • GO:0035332
  • GO:0042752
  • GO:0043066
  • GO:0044297
  • GO:0045475
  • GO:0045732
  • GO:0045879
  • GO:0045880
  • GO:0048148
  • GO:0048511
  • GO:0051781
  • GO:0071482
  • GO:0090175
  • GO:0090263
  • GO:0106310
  • GO:0140096
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DCO_DROME
  • A4V3P5
  • Q0KHY4
  • Q9V462
sequenceLength 440
species [Species:56210] Drosophila melanogaster
stId uniprot:O76324
url http://purl.uniprot.org/uniprot/O76324
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