Reactome | UniProt:O76061 STC2

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UniProt:O76061 STC2 Show undefined attributes

chain	signal peptide:1-24 chain:25-302
checksum	9B90D8911524FA22
comment	FUNCTION Has an anti-hypocalcemic action on calcium and phosphate homeostasis.SUBUNIT Homodimer; disulfide-linked.SUBCELLULAR LOCATION Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.SIMILARITY Belongs to the stanniocalcin family.
crossReference	[DatabaseIdentifier:12451974] RefSeq:NP_003705.1 [DatabaseIdentifier:12284406] Pharos - Targets:O76061 [DatabaseIdentifier:12262914] PRO:O76061 [DatabaseIdentifier:12171264] PDB:7Y5Q [DatabaseIdentifier:12171265] PDB:8HGH [DatabaseIdentifier:12171266] PDB:8A7D [DatabaseIdentifier:12171267] PDB:8A7E [DatabaseIdentifier:12124090] OpenTargets:ENSG00000113739 [DatabaseIdentifier:11839565] HPA:ENSG00000113739-STC2 [DatabaseIdentifier:11829776] HMDB Protein:HMDBP08014 [DatabaseIdentifier:11801983] GlyGen:O76061 [DatabaseIdentifier:11786488] GeneCards:STC2 [DatabaseIdentifier:11749571] ENSEMBL:ENST00000265087 [DatabaseIdentifier:11626872] ENSEMBL:ENSP00000265087 [DatabaseIdentifier:11511531] ENSEMBL:ENSG00000113739
databaseName	UniProt
dbId	65178
description	recommendedName: Stanniocalcin-2 shortName: STC-2 alternativeName: Stanniocalcin-related protein shortName: STC-related protein shortName: STCRP
displayName	UniProt:O76061 STC2
geneName	STC2
identifier	O76061
isSequenceChanged	false
keyword	3D-structure Disulfide bond Glycoprotein Hormone Phosphoprotein Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	STC2
otherIdentifier	11721435_at 11721436_a_at 11721437_a_at 17002898 203438_PM_at 203438_at 203439_PM_s_at 203439_s_at 2887483 2887494 2887495 2887496 2887497 2887498 2887499 2887504 2887505 2887506 2887510 2887511 2887517 2887518 2887519 32043_at 43045_at 8115851 8614 A_23_P110686 A_23_P416395 GE79742 GO:0005179 GO:0005576 GO:0005615 GO:0005783 GO:0005788 GO:0005794 GO:0006874 GO:0006979 GO:0007165 GO:0007566 GO:0010629 GO:0019899 GO:0020037 GO:0022414 GO:0030968 GO:0033280 GO:0034976 GO:0040015 GO:0042803 GO:0043434 GO:0046697 GO:0046885 GO:0048018 GO:0048471 GO:0048856 GO:0055074 GO:0071456 GO:0098772 GO:2001256 HMNXSV003022430 Hs.155223.0.S4_3p_at ILMN_1691884 PH_hs_0009352 TC05002075.hg g12653744_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8957078] p-STC2 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8956705] STC2 [endoplasmic reticulum lumen] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12763014] UCSC:O76061 STC2 [ReferenceDNASequence:12109534] OMIM:603665 STC2 [ReferenceDNASequence:12090089] NCBI Gene:8614 STC2 [ReferenceDNASequence:12005996] Monarch:8614 STC2 [ReferenceDNASequence:11913728] KEGG:hsa:8614 STC2 [ReferenceDNASequence:11818124] HGNC:11374 STC2 [ReferenceDNASequence:11440787] dbSNP Gene:8614 STC2 [ReferenceDNASequence:11411576] CTD Gene:8614 STC2 [ReferenceDNASequence:11403200] COSMIC - genes:STC2 STC2 [ReferenceDNASequence:11376207] BioGPS Gene:8614 STC2 [ReferenceDNASequence:ensembl:ENSG00000113739] ENSEMBL:ENSG00000113739 STC2
referenceTranscript	[ReferenceRNASequence:12633516] RefSeq:NM_003714.3 STC2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	STC2_HUMAN
sequenceLength	302
species	[Species:48887] Homo sapiens
stId	uniprot:O76061
url	http://purl.uniprot.org/uniprot/O76061

Referrals

(interactor)	[UndirectedInteraction:11152935] UniProt:P0DTC8 <-> UniProt:O76061 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8957078] p-STC2 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8956705] STC2 [endoplasmic reticulum lumen]
(referenceSequence)	[ModifiedResidue:8956948] phosphorylated residue at unknown position