Reactome | UniProt:O75694 NUP155

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UniProt:O75694 NUP155 Show undefined attributes

chain	initiator methionine:1 chain:2-1391
checksum	7F07A103AFF7EE1D
comment	FUNCTION Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.SUBUNIT Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUP42 in vitro. Forms a complex with NUP35, NUP93, NUP205 and lamin B.INTERACTION In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis.ALTERNATIVE PRODUCTS Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.PTM Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).PTM Disulfide-linked to NUP62. The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the non-repetitive/WGA-negative nucleoporin family.SEQUENCE CAUTION Extended N-terminus.
crossReference	[DatabaseIdentifier:12328150] RefSeq:NP_004289.1 [DatabaseIdentifier:12328149] RefSeq:NP_705618.1 [DatabaseIdentifier:12287706] Pharos - Targets:O75694 [DatabaseIdentifier:12248258] PRO:O75694 [DatabaseIdentifier:12192332] PDB:7EYE [DatabaseIdentifier:12160447] PDB:7PER [DatabaseIdentifier:12192334] PDB:7R1Y [DatabaseIdentifier:12140500] PDB:7R5J [DatabaseIdentifier:12140501] PDB:7R5K [DatabaseIdentifier:12160445] PDB:5IJO [DatabaseIdentifier:12160446] PDB:5IJN [DatabaseIdentifier:12192333] PDB:7EYF [DatabaseIdentifier:12155016] PDB:5A9Q [DatabaseIdentifier:12192335] PDB:7EYQ [DatabaseIdentifier:12135455] Orphanet:NUP155 [DatabaseIdentifier:12127477] OpenTargets:ENSG00000113569 [DatabaseIdentifier:11842882] HPA:ENSG00000113569-NUP155 [DatabaseIdentifier:11805590] GlyGen:O75694 [DatabaseIdentifier:11789857] GeneCards:NUP155 [DatabaseIdentifier:11667166] ENSEMBL:ENST00000381843 [DatabaseIdentifier:11667165] ENSEMBL:ENST00000231498 [DatabaseIdentifier:11544466] ENSEMBL:ENSP00000231498 [DatabaseIdentifier:11544467] ENSEMBL:ENSP00000371265 [DatabaseIdentifier:11454319] ENSEMBL:ENSG00000113569
databaseName	UniProt
dbId	69914
description	recommendedName: Nuclear pore complex protein Nup155 alternativeName: 155 kDa nucleoporin alternativeName: Nucleoporin Nup155
displayName	UniProt:O75694 NUP155
geneName	NUP155 KIAA0791
identifier	O75694
isSequenceChanged	false
keyword	3D-structure Alternative splicing Atrial fibrillation Disease variant Disulfide bond Glycoprotein Isopeptide bond Membrane mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Translocation Transport Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	NUP155
otherIdentifier	11737301_a_at 1559006_PM_at 1559006_at 1559007_PM_s_at 1559007_s_at 16995409 206550_PM_s_at 206550_s_at 2853763 2853765 2853767 2853769 2853770 2853771 2853772 2853773 2853774 2853775 2853776 2853777 2853778 2853779 2853781 2853782 2853783 2853784 2853785 2853786 2853787 2853788 2853789 2853790 2853791 2853792 2853793 2853794 2853795 2853796 2853798 2853799 2853800 2853801 2853803 2853804 2853806 2853807 2853808 2853809 2853810 2853811 2853812 2853813 2853814 2853815 2853816 2853817 2853819 2853820 2853821 2976709 34659_at 51983_at 58163_i_at 58167_r_at 8111629 9631 A_23_P7679 A_32_P142149 GE53491 GE819508 GO:0000972 GO:0005515 GO:0005634 GO:0005635 GO:0005643 GO:0005829 GO:0006405 GO:0006406 GO:0006606 GO:0006886 GO:0006913 GO:0006998 GO:0015031 GO:0016020 GO:0017056 GO:0031965 GO:0034504 GO:0035196 GO:0036228 GO:0044611 GO:0051028 GO:0061024 GO:0086014 HMNXSV003050694 Hs2.397001.1.S1_3p_s_at ILMN_1761772 ILMN_1768293 PH_hs_0002047 PH_hs_0008527 TC05001275.hg g4758843_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9634170] NUP155 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-157690] NUP155 [nuclear envelope] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12727495] UCSC:O75694 NUP155 [ReferenceDNASequence:12112351] OMIM:606694 NUP155 [ReferenceDNASequence:12033192] NCBI Gene:9631 NUP155 [ReferenceDNASequence:11949099] Monarch:9631 NUP155 [ReferenceDNASequence:11862263] KEGG:hsa:9631 NUP155 [ReferenceDNASequence:11821513] HGNC:8063 NUP155 [ReferenceDNASequence:11434782] dbSNP Gene:9631 NUP155 [ReferenceDNASequence:11416859] CTD Gene:9631 NUP155 [ReferenceDNASequence:11398012] COSMIC - genes:NUP155 NUP155 [ReferenceDNASequence:11319310] BioGPS Gene:9631 NUP155 [ReferenceDNASequence:ensembl:ENSG00000113569] ENSEMBL:ENSG00000113569 NUP155
referenceTranscript	[ReferenceRNASequence:12510060] RefSeq:NM_153485.3 NUP155 [ReferenceRNASequence:12510059] RefSeq:NM_004298.4 NUP155
schemaClass	ReferenceGeneProduct
secondaryIdentifier	NU155_HUMAN Q9UBE9 Q9UFL5
sequenceLength	1391
species	[Species:48887] Homo sapiens
stId	uniprot:O75694
url	http://purl.uniprot.org/uniprot/O75694

Referrals

(interactor)	[UndirectedInteraction:11292747] UniProt:P43353 <-> UniProt:O75694 (IntAct) [UndirectedInteraction:11245267] UniProt:Q13519 <-> UniProt:O75694 (IntAct) [UndirectedInteraction:11240077] UniProt:P02545 <-> UniProt:O75694 (IntAct) [UndirectedInteraction:11149387] UniProt:P13569 <-> UniProt:O75694 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9634170] NUP155 [cytosol] [EntityWithAccessionedSequence:R-HSA-157690] NUP155 [nuclear envelope]