Reactome | UniProt:O75691 UTP20

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UniProt:O75691 UTP20 Show undefined attributes

chain	chain:1-2785
checksum	0CE63611C8440E0D
comment	FUNCTION Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.SUBUNIT Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797). Interacts with FBL and PPP1R26 (PubMed:16053918, PubMed:17498821).INTERACTION Colocalizes with NCL in the nucleolus.TISSUE SPECIFICITY Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.SIMILARITY Belongs to the UTP20 family.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12328158] RefSeq:NP_055318.2 [DatabaseIdentifier:12287709] Pharos - Targets:O75691 [DatabaseIdentifier:12248265] PRO:O75691 [DatabaseIdentifier:12140947] PDB:7MQ8 [DatabaseIdentifier:12140101] PDB:7MQA [DatabaseIdentifier:12140946] PDB:7MQ9 [DatabaseIdentifier:12127480] OpenTargets:ENSG00000120800 [DatabaseIdentifier:11842885] HPA:ENSG00000120800-UTP20 [DatabaseIdentifier:11805594] GlyGen:O75691 [DatabaseIdentifier:11789860] GeneCards:UTP20 [DatabaseIdentifier:11667173] ENSEMBL:ENST00000261637 [DatabaseIdentifier:11544474] ENSEMBL:ENSP00000261637 [DatabaseIdentifier:11454326] ENSEMBL:ENSG00000120800
databaseName	UniProt
dbId	254000
description	recommendedName: Small subunit processome component 20 homolog alternativeName: Down-regulated in metastasis protein alternativeName: Novel nucleolar protein 73 shortName: NNP73 alternativeName: Protein Key-1A6
displayName	UniProt:O75691 UTP20
geneName	UTP20 DRIM
identifier	O75691
isSequenceChanged	false
keyword	3D-structure Coiled coil Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat rRNA processing
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	UTP20
otherIdentifier	11731664_at 16755750 209725_PM_at 209725_at 27340 3428453 3428454 3428455 3428456 3428457 3428458 3428460 3428462 3428463 3428464 3428465 3428466 3428467 3428468 3428469 3428470 3428473 3428474 3428475 3428476 3428477 3428479 3428482 3428483 3428485 3428488 3428489 3428490 3428492 3428493 3428494 3428496 3428497 3428498 3428499 3428500 3428501 3428502 3428503 3428504 3428505 3428506 3428507 3428508 3428509 3428510 3428511 3428512 3428513 3428515 3428516 3428518 3428519 3428520 3428521 3428522 3428523 3428525 3428526 3428527 3428528 3428529 3428530 3428531 3428532 3428533 3428534 3428535 3428536 3428538 3428539 3428540 3428543 3428545 3428546 3428547 38560_at 7957890 A_14_P101912 A_14_P119341 A_23_P162525 GE61400 GO:0000447 GO:0000472 GO:0000480 GO:0003723 GO:0005515 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005886 GO:0006364 GO:0008285 GO:0030686 GO:0030688 GO:0032040 GO:0042274 HMNXSV003016798 HMNXSV003019327 ILMN_1724106 ILMN_2102580 PH_hs_0023565 TC12000781.hg g11464475_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6790692] UTP20 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12727503] UCSC:O75691 UTP20 [ReferenceDNASequence:12112353] OMIM:612822 UTP20 [ReferenceDNASequence:12033200] NCBI Gene:27340 UTP20 [ReferenceDNASequence:11949107] Monarch:27340 UTP20 [ReferenceDNASequence:11862269] KEGG:hsa:27340 UTP20 [ReferenceDNASequence:11821516] HGNC:17897 UTP20 [ReferenceDNASequence:11434785] dbSNP Gene:27340 UTP20 [ReferenceDNASequence:11416863] CTD Gene:27340 UTP20 [ReferenceDNASequence:11398015] COSMIC - genes:UTP20 UTP20 [ReferenceDNASequence:11319318] BioGPS Gene:27340 UTP20 [ReferenceDNASequence:ensembl:ENSG00000120800] ENSEMBL:ENSG00000120800 UTP20
referenceTranscript	[ReferenceRNASequence:12510068] RefSeq:NM_014503.3 UTP20
schemaClass	ReferenceGeneProduct
secondaryIdentifier	UTP20_HUMAN Q9H3H4
sequenceLength	2785
species	[Species:48887] Homo sapiens
stId	uniprot:O75691
url	http://purl.uniprot.org/uniprot/O75691

Referrals

(interactor)	[UndirectedInteraction:11304615] UniProt:P20333 <-> UniProt:O75691 (IntAct) [UndirectedInteraction:11293491] UniProt:Q9Y639 <-> UniProt:O75691 (IntAct) [UndirectedInteraction:11247341] UniProt:Q9NZQ7 <-> UniProt:O75691 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6790692] UTP20 [nucleoplasm]