UniProt:O75593 FOXH1

chain
  • chain:1-365
checksum 27A13F39C089F722
comment
  • FUNCTION Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).SUBUNIT Interacts with the MH2 domains of SMAD2 and SMAD3.INTERACTION Ubiquitous.DOMAIN The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex (By similarity).
crossReference
databaseName UniProt
dbId 55106
description
  • recommendedName: Forkhead box protein H1 alternativeName: Forkhead activin signal transducer 1 shortName: Fast-1 shortName: hFAST-1 alternativeName: Forkhead activin signal transducer 2 shortName: Fast-2
displayName UniProt:O75593 FOXH1
geneName
  • FOXH1
  • FAST1
  • FAST2
identifier O75593
isSequenceChanged false
keyword
  • 3D-structure
  • Activator
  • DNA-binding
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • FOXH1
otherIdentifier
  • 11732008_a_at
  • 17082752
  • 207644_PM_at
  • 207644_at
  • 231407_PM_s_at
  • 231407_s_at
  • 3158742
  • 3158743
  • 3158744
  • 3158745
  • 3158746
  • 3158747
  • 3158748
  • 3158749
  • 3158750
  • 3158751
  • 3158752
  • 31912_at
  • 3231251
  • 50227_s_at
  • 8153828
  • 8928
  • GE79568
  • GO:0000122
  • GO:0000785
  • GO:0000976
  • GO:0000981
  • GO:0000987
  • GO:0001228
  • GO:0001947
  • GO:0003139
  • GO:0003140
  • GO:0003151
  • GO:0003215
  • GO:0003222
  • GO:0003677
  • GO:0003700
  • GO:0003714
  • GO:0005515
  • GO:0005634
  • GO:0005667
  • GO:0006355
  • GO:0006357
  • GO:0007179
  • GO:0007368
  • GO:0009952
  • GO:0019904
  • GO:0032444
  • GO:0035054
  • GO:0035909
  • GO:0038092
  • GO:0043425
  • GO:0043565
  • GO:0045893
  • GO:0045944
  • GO:0046332
  • GO:0048318
  • GO:0048856
  • GO:0050681
  • GO:0060766
  • GO:0070365
  • GO:0070410
  • GO:0070412
  • GO:0071345
  • GO:0140297
  • HMNXSV003009175
  • Hs.92679.0.A1_3p_at
  • ILMN_1798808
  • PH_hs_0009678
  • TC08001753.hg
  • g4503656_3p_at
  • g4503656_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • FOXH1_HUMAN
  • D3DWM4
sequenceLength 365
species [Species:48887] Homo sapiens
stId uniprot:O75593
url http://purl.uniprot.org/uniprot/O75593

Referrals

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