UniProt:O75529 TAF5L

chain
  • chain:1-589
checksum BBF0A1CDD17EE22E
comment
  • FUNCTION Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity).SUBUNIT The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.INTERACTION May be due to an intron retention.SIMILARITY Belongs to the WD repeat TAF5 family.
created [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
crossReference
databaseName UniProt
dbId 154656
description
  • recommendedName: fullName evidence="7"TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L shortName evidence="7"TAF5L alternativeName: PCAF-associated factor 65 beta shortName: PAF65-beta
displayName UniProt:O75529 TAF5L
geneName
  • TAF5L
  • PAF65B
identifier O75529
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Direct protein sequencing
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
  • WD repeat
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • TAF5L
otherIdentifier
  • 11726472_at
  • 11736606_a_at
  • 1554415_PM_at
  • 1554415_at
  • 16700343
  • 213654_PM_at
  • 213654_at
  • 2459972
  • 2459973
  • 2459974
  • 2459975
  • 2459976
  • 2459977
  • 2459978
  • 2459980
  • 2459981
  • 2459983
  • 2459984
  • 2459987
  • 2459988
  • 27097
  • 35186_at
  • 7924969
  • 85119_r_at
  • A_23_P35309
  • A_24_P376441
  • A_33_P3242323
  • GE55184
  • GO:0000124
  • GO:0003713
  • GO:0005515
  • GO:0005634
  • GO:0006282
  • GO:0006351
  • GO:0006355
  • GO:0006357
  • GO:0006366
  • GO:0016607
  • GO:0033276
  • GO:0036464
  • GO:0043226
  • GO:0043484
  • GO:0045893
  • GO:1904672
  • HMNXSV003003327
  • HMNXSV003022097
  • HMNXSV003047404
  • Hs.26782.0.S2_3p_at
  • Hs2.26782.2.S1_3p_at
  • ILMN_1797056
  • ILMN_2252813
  • PH_hs_0002367
  • PH_hs_0040886
  • TC01003951.hg
  • TC01006180.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TAF5L_HUMAN
  • Q5TDI5
  • Q5TDI6
  • Q8IW31
sequenceLength 589
species [Species:48887] Homo sapiens
stId uniprot:O75529
url http://purl.uniprot.org/uniprot/O75529
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