Reactome | UniProt:O75475 PSIP1

Schema > ReferenceGeneProduct > Entries

UniProt:O75475 PSIP1 Show undefined attributes

chain	chain:1-530
checksum	4B653D02B1D0E174
comment	FUNCTION Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.SUBUNIT Monomer (PubMed:15895093). Interacts with IFRD1/PC4 (PubMed:9822615). Isoform 2 interacts with SFRS1 (PubMed:9885563). Isoform 1 interacts (via IBD domain) with POGZ (via IBM motif) and CDCA7L (via IBM motifs) (PubMed:19244240, PubMed:25082813, PubMed:29997176). Interacts (via IBD domain) with KMT2A (via IBM motifs) with a moderate affinity whereas interacts with the KMT2A-MEN1 complex with a greater affinity; MEN1 enhances interaction of KMT2A with PSIP1 (PubMed:22327296, PubMed:25082813, PubMed:25305204, PubMed:29997176). Interacts with fusion protein KMT2A-MLLT3 (PubMed:25305204). Interacts (via IBD domain) with IWS1 (via IBM motif), MED1 (via IBM motif) and DBF4 (via IBM motifs) (PubMed:29997176).SUBUNIT (Microbial infection) Interacts (via IBD domain) with human HIV-1 integrase protein (HIV-1 IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome.SUBUNIT (Microbial infection) Interacts with HIV-2 IN.INTERACTION Remains chromatin-associated throughout the cell cycle.ALTERNATIVE PRODUCTS Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.PTM Citrullinated by PADI4.DISEASE A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4.MISCELLANEOUS Less active than isoform 2 as transcriptional coactivator, but more abundant in cells.SIMILARITY Belongs to the HDGF family.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:12163926] PDB:6EMR [DatabaseIdentifier:12331266] RefSeq:NP_001121689.1 [DatabaseIdentifier:12331269] RefSeq:NP_150091.2 [DatabaseIdentifier:12331263] RefSeq:NP_001425315.1 [DatabaseIdentifier:12331262] RefSeq:NP_001425318.1 [DatabaseIdentifier:12331264] RefSeq:NP_001425314.1 [DatabaseIdentifier:12331267] RefSeq:NP_001304829.1 [DatabaseIdentifier:12331268] RefSeq:NP_066967.3 [DatabaseIdentifier:12331265] RefSeq:NP_001304827.1 [DatabaseIdentifier:12288258] Pharos - Targets:O75475 [DatabaseIdentifier:12249358] PRO:O75475 [DatabaseIdentifier:12203010] PDB:3HPH [DatabaseIdentifier:12202995] PDB:7OUF [DatabaseIdentifier:12203004] PDB:6EMQ [DatabaseIdentifier:12203006] PDB:2B4J [DatabaseIdentifier:12203007] PDB:9BW9 [DatabaseIdentifier:12191730] PDB:6EMP [DatabaseIdentifier:12202997] PDB:2M16 [DatabaseIdentifier:12203005] PDB:2MSR [DatabaseIdentifier:12202996] PDB:7Z1Z [DatabaseIdentifier:12166091] PDB:8PC5 [DatabaseIdentifier:12203009] PDB:3HPG [DatabaseIdentifier:12166093] PDB:8PC6 [DatabaseIdentifier:12202998] PDB:5OYM [DatabaseIdentifier:12202993] PDB:7OUG [DatabaseIdentifier:12203011] PDB:7PEL [DatabaseIdentifier:12166137] PDB:8PEP [DatabaseIdentifier:12191731] PDB:2N3A [DatabaseIdentifier:11455764] ENSEMBL:ENSG00000164985 [DatabaseIdentifier:11546496] ENSEMBL:ENSP00000370091 [DatabaseIdentifier:11546492] ENSEMBL:ENSP00000370109 [DatabaseIdentifier:11546493] ENSEMBL:ENSP00000380653 [DatabaseIdentifier:11546495] ENSEMBL:ENSP00000370092 [DatabaseIdentifier:11546494] ENSEMBL:ENSP00000370114 [DatabaseIdentifier:11669192] ENSEMBL:ENST00000380738 [DatabaseIdentifier:11669195] ENSEMBL:ENST00000397519 [DatabaseIdentifier:11669194] ENSEMBL:ENST00000380733 [DatabaseIdentifier:11669191] ENSEMBL:ENST00000380715 [DatabaseIdentifier:11669193] ENSEMBL:ENST00000380716 [DatabaseIdentifier:11790415] GeneCards:PSIP1 [DatabaseIdentifier:11806328] GlyGen:O75475 [DatabaseIdentifier:11843425] HPA:ENSG00000164985-PSIP1 [DatabaseIdentifier:12128034] OpenTargets:ENSG00000164985 [DatabaseIdentifier:12202988] PDB:2MTN [DatabaseIdentifier:12166112] PDB:6S01 [DatabaseIdentifier:12165999] PDB:8CBQ [DatabaseIdentifier:12166135] PDB:8PEO [DatabaseIdentifier:12202994] PDB:7OUH [DatabaseIdentifier:12202989] PDB:4FU6 [DatabaseIdentifier:12202999] PDB:3U88 [DatabaseIdentifier:12203003] PDB:6EMO [DatabaseIdentifier:12202992] PDB:6TRJ [DatabaseIdentifier:12203012] PDB:3F9K [DatabaseIdentifier:12203008] PDB:3ZEH [DatabaseIdentifier:12203000] PDB:5N88 [DatabaseIdentifier:12166004] PDB:8CBN [DatabaseIdentifier:12202991] PDB:5YI9 [DatabaseIdentifier:12203001] PDB:1Z9E [DatabaseIdentifier:12202990] PDB:6TVM [DatabaseIdentifier:12203002] PDB:6ZV0
databaseName	UniProt
dbId	401858
description	recommendedName: PC4 and SFRS1-interacting protein alternativeName: CLL-associated antigen KW-7 alternativeName: Dense fine speckles 70 kDa protein shortName: DFS 70 alternativeName: Lens epithelium-derived growth factor alternativeName: Transcriptional coactivator p75/p52
displayName	UniProt:O75475 PSIP1
geneName	PSIP1 DFS70 LEDGF PSIP2
identifier	O75475
isSequenceChanged	false
keyword	3D-structure Alternative splicing Chromosomal rearrangement Citrullination Coiled coil Direct protein sequencing DNA-binding Host-virus interaction Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	PSIP1
otherIdentifier	11168 11734600_a_at 11742933_a_at 11761869_at 1554933_PM_at 1554933_at 17092615 205961_PM_s_at 205961_s_at 209337_PM_at 209337_at 210758_PM_at 210758_at 3163066 3199789 3199791 3199792 3199793 3199796 3199798 3199799 3199800 3199801 3199802 3199803 3199804 3199805 3199806 3199807 3199808 3199809 3199810 3199812 3199814 3199815 3199816 3199817 3199818 3199820 3199822 3199823 3199824 3199825 3199826 3199827 3199828 37622_r_at 39243_s_at 70817_r_at 8160238 8180299 A_23_P256384 A_24_P929106 A_24_P98371 A_32_P22702 A_32_P32043 A_33_P3226605 A_33_P3226610 GE54580 GO:0000395 GO:0000791 GO:0000792 GO:0003677 GO:0003682 GO:0003713 GO:0003723 GO:0005515 GO:0005634 GO:0005654 GO:0005829 GO:0006325 GO:0006338 GO:0006355 GO:0006979 GO:0009408 GO:0034399 GO:0045944 GO:0065003 GO:0097100 GO:0140297 HMNXSV003010046 HMNXSV003042644 Hs2.375073.1.S1_3p_x_at ILMN_1679319 ILMN_1788701 PH_hs_0023938 TC09000925.hg U94319_at g3283351_3p_at g4050033_3p_at g4758869_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-3008840] PSIP1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-3008841] PSIP1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000164985] ENSEMBL:ENSG00000164985 PSIP1 [ReferenceDNASequence:12728351] UCSC:O75475 PSIP1 [ReferenceDNASequence:11320613] BioGPS Gene:11168 PSIP1 [ReferenceDNASequence:11398142] COSMIC - genes:PSIP1 PSIP1 [ReferenceDNASequence:11417786] CTD Gene:11168 PSIP1 [ReferenceDNASequence:11434925] dbSNP Gene:11168 PSIP1 [ReferenceDNASequence:11822076] HGNC:9527 PSIP1 [ReferenceDNASequence:11863419] KEGG:hsa:11168 PSIP1 [ReferenceDNASequence:11950402] Monarch:11168 PSIP1 [ReferenceDNASequence:12034495] NCBI Gene:11168 PSIP1 [ReferenceDNASequence:12112841] OMIM:603620 PSIP1
referenceTranscript	[ReferenceRNASequence:12513168] RefSeq:NM_001438389.1 PSIP1 [ReferenceRNASequence:12513171] RefSeq:NM_001128217.3 PSIP1 [ReferenceRNASequence:12513172] RefSeq:NM_001438386.1 PSIP1 [ReferenceRNASequence:12513173] RefSeq:NM_033222.4 PSIP1 [ReferenceRNASequence:12513174] RefSeq:NM_001317900.1 PSIP1 [ReferenceRNASequence:12513167] RefSeq:NM_001438385.1 PSIP1 [ReferenceRNASequence:12513169] RefSeq:NM_001317898.3 PSIP1 [ReferenceRNASequence:12513170] RefSeq:NM_021144.3 PSIP1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PSIP1_HUMAN D3DRI9 O00256 O95368 Q6P391 Q86YB9 Q9NZI3 Q9UER6
sequenceLength	530
species	[Species:48887] Homo sapiens
stId	uniprot:O75475
url	http://purl.uniprot.org/uniprot/O75475

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-3008840] PSIP1 [cytosol] [EntityWithAccessionedSequence:R-HSA-3008841] PSIP1 [nucleoplasm]
(interactor)	[UndirectedInteraction:11221217] UniProt:O75475 <-> UniProt:Q99708 (IntAct) [UndirectedInteraction:11221219] UniProt:O75475 <-> UniProt:Q03164 (IntAct)