Reactome | UniProt:O75448 MED24

chain	chain:1-989
checksum	CCEDE7D4E74D890C
comment	FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR.INTERACTION Ubiquitous. Abundant in skeletal muscle, heart and placenta.SIMILARITY Belongs to the Mediator complex subunit 24 family.
crossReference	[DatabaseIdentifier:11455859] ENSEMBL:ENSG00000008838 [DatabaseIdentifier:12331469] RefSeq:NP_055630.2 [DatabaseIdentifier:12331467] RefSeq:NP_001254726.1 [DatabaseIdentifier:12331468] RefSeq:NP_001072986.1 [DatabaseIdentifier:12288304] Pharos - Targets:O75448 [DatabaseIdentifier:12249449] PRO:O75448 [DatabaseIdentifier:12139978] PDB:8TQW [DatabaseIdentifier:12139975] PDB:7ENJ [DatabaseIdentifier:12139983] PDB:7EMF [DatabaseIdentifier:12139976] PDB:8GXS [DatabaseIdentifier:12139980] PDB:7ENC [DatabaseIdentifier:12139982] PDB:7ENA [DatabaseIdentifier:12139984] PDB:8T9D [DatabaseIdentifier:12139979] PDB:8TRH [DatabaseIdentifier:12138290] PDB:7LBM [DatabaseIdentifier:12139977] PDB:8GXQ [DatabaseIdentifier:12128080] OpenTargets:ENSG00000008838 [DatabaseIdentifier:11546641] ENSEMBL:ENSP00000377685 [DatabaseIdentifier:11546643] ENSEMBL:ENSP00000348610 [DatabaseIdentifier:11546642] ENSEMBL:ENSP00000377686 [DatabaseIdentifier:11669341] ENSEMBL:ENST00000394128 [DatabaseIdentifier:11669342] ENSEMBL:ENST00000356271 [DatabaseIdentifier:11669340] ENSEMBL:ENST00000394127 [DatabaseIdentifier:11790462] GeneCards:MED24 [DatabaseIdentifier:11806397] GlyGen:O75448 [DatabaseIdentifier:11843469] HPA:ENSG00000008838-MED24
databaseName	UniProt
dbId	65500
description	recommendedName: Mediator of RNA polymerase II transcription subunit 24 alternativeName: Activator-recruited cofactor 100 kDa component shortName: ARC100 alternativeName: Cofactor required for Sp1 transcriptional activation subunit 4 shortName: CRSP complex subunit 4 alternativeName: Mediator complex subunit 24 alternativeName: Thyroid hormone receptor-associated protein 4 alternativeName: Thyroid hormone receptor-associated protein complex 100 kDa component shortName: Trap100 shortName: hTRAP100 alternativeName: Vitamin D3 receptor-interacting protein complex 100 kDa component shortName: DRIP100
displayName	UniProt:O75448 MED24
geneName	MED24 ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100
identifier	O75448
isSequenceChanged	false
keyword	3D-structure Activator Alternative splicing Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	MED24
otherIdentifier	11747336_x_at 11750617_x_at 11752472_a_at 11752473_x_at 11752617_a_at 11752618_x_at 11753634_a_at 11753635_x_at 11753701_x_at 11755946_x_at 11763917_at 16844248 16844292 213043_PM_s_at 213043_s_at 34289_f_at 34290_f_at 3755977 3755978 3755979 3755980 3755981 3755982 3755983 3755984 3755985 3755986 3755987 3755988 3755989 3755990 3755991 3755992 3755993 3755994 3755995 3755996 3755997 3755998 3755999 3756000 3756001 3756002 3756003 3756004 3756005 3756006 3756007 3756008 3756010 3756011 3756012 3756013 3756014 3756015 3756016 3756017 3756018 3756019 3756020 3756021 3756022 3756023 3756024 3756025 3756028 3756029 3756030 3756031 3756032 3756033 3756034 3756035 74837_r_at 8014925 9862 A_23_P124760 A_33_P3755633 D50920_at GE57256 GE649929 GO:0003712 GO:0003713 GO:0005515 GO:0005634 GO:0005654 GO:0006351 GO:0006355 GO:0006366 GO:0016592 GO:0032968 GO:0035019 GO:0042809 GO:0045893 GO:0046966 GO:0051123 GO:0060261 GO:0065003 GO:0070847 HMNXSV003040211 HMNXSV003042548 HMNXSV003049395 HMNXSV003056229 Hs.23106.1.A1_3p_a_at ILMN_1711853 ILMN_2388272 PH_hs_0002027 RNA33553\|snoRNA_scaRNA_149_104 TC17001457.hg TC17001458.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-212331] MED24 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11950497] Monarch:9862 MED24 [ReferenceDNASequence:12728383] UCSC:O75448 MED24 [ReferenceDNASequence:12112886] OMIM:607000 MED24 [ReferenceDNASequence:12034590] NCBI Gene:9862 MED24 [ReferenceDNASequence:ensembl:ENSG00000008838] ENSEMBL:ENSG00000008838 MED24 [ReferenceDNASequence:11320708] BioGPS Gene:9862 MED24 [ReferenceDNASequence:11398151] COSMIC - genes:MED24 MED24 [ReferenceDNASequence:11417847] CTD Gene:9862 MED24 [ReferenceDNASequence:11434935] dbSNP Gene:9862 MED24 [ReferenceDNASequence:11822123] HGNC:22963 MED24 [ReferenceDNASequence:11863508] KEGG:hsa:9862 MED24
referenceTranscript	[ReferenceRNASequence:12513374] RefSeq:NM_001267797.2 MED24 [ReferenceRNASequence:12513372] RefSeq:NM_001079518.2 MED24 [ReferenceRNASequence:12513373] RefSeq:NM_014815.3 MED24
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MED24_HUMAN A8K4S5 B3KMR9 Q14143 Q9NNY5
sequenceLength	989
species	[Species:48887] Homo sapiens
stId	uniprot:O75448
url	http://purl.uniprot.org/uniprot/O75448

UniProt:O75448 MED24 Show undefined attributes

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