UniProt:O75386 TULP3

chain
  • chain:1-442
checksum 13DBC83305BFAC1D
comment
  • FUNCTION Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes.SUBUNIT Associates with the IFT complex A (IFT-A) (PubMed:20889716, PubMed:27932497). Interacts with SIRT1 (PubMed:35397207).INTERACTION Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha.ALTERNATIVE PRODUCTS Expressed at high levels in testis, ovaries, thyroid, and spinal cord.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TUB family.
crossReference
databaseName UniProt
dbId 66565
description
  • recommendedName: fullName evidence="10"Tubby-related protein 3 alternativeName: Tubby-like protein 3
displayName UniProt:O75386 TULP3
geneName
  • TULP3
  • TUBL3
identifier O75386
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Ciliopathy
  • Cilium
  • Cytoplasm
  • Developmental protein
  • Disease variant
  • Membrane
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Secreted
modified [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType Protein
name
  • TULP3
otherIdentifier
  • 11739643_a_at
  • 11739644_a_at
  • 11739645_x_at
  • 11739646_a_at
  • 11748397_x_at
  • 11751660_a_at
  • 11751661_x_at
  • 16746878
  • 16746904
  • 205854_PM_at
  • 205854_at
  • 221964_PM_at
  • 221964_at
  • 31942_at
  • 31943_g_at
  • 31944_at
  • 3401200
  • 3401218
  • 3401219
  • 3401220
  • 3401228
  • 3401230
  • 3401231
  • 3401233
  • 3401235
  • 3401237
  • 3401240
  • 3401242
  • 3401244
  • 3401245
  • 3401246
  • 3401247
  • 3401248
  • 3401249
  • 3401250
  • 3401251
  • 3401252
  • 3401253
  • 3401254
  • 45162_at
  • 7289
  • 74737_at
  • 74739_g_at
  • 7953135
  • 82197_at
  • A_23_P420782
  • A_33_P3405789
  • GE54396
  • GO:0001664
  • GO:0001841
  • GO:0001843
  • GO:0005515
  • GO:0005546
  • GO:0005576
  • GO:0005634
  • GO:0005654
  • GO:0005730
  • GO:0005737
  • GO:0005815
  • GO:0005886
  • GO:0005929
  • GO:0005930
  • GO:0006355
  • GO:0007186
  • GO:0007224
  • GO:0007420
  • GO:0008277
  • GO:0008589
  • GO:0009952
  • GO:0016020
  • GO:0019899
  • GO:0021513
  • GO:0021904
  • GO:0021915
  • GO:0021953
  • GO:0031076
  • GO:0035091
  • GO:0036064
  • GO:0042733
  • GO:0042995
  • GO:0043226
  • GO:0044877
  • GO:0045879
  • GO:0048702
  • GO:0048856
  • GO:0060173
  • GO:0060348
  • GO:0060434
  • GO:0060831
  • GO:0061512
  • GO:0061548
  • GO:0097546
  • GO:0097731
  • GO:0120160
  • HMNXSV003051018
  • Hs.169084.0.S2_3p_at
  • Hs.39706.0.A1_3p_at
  • ILMN_1719199
  • PH_hs_0028438
  • TC12003230.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TULP3_HUMAN
  • B3KNB7
  • B7Z6A2
  • D3DUQ4
  • F8WBZ9
  • Q8N5B0
sequenceLength 442
species [Species:48887] Homo sapiens
stId uniprot:O75386
url http://purl.uniprot.org/uniprot/O75386

Referrals

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