UniProt:O75348 ATP6V1G1

chain
  • initiator methionine:1
  • chain:2-118
checksum A289C1B96634E34C
comment
  • FUNCTION Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).SUBUNIT V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (PubMed:33065002). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (PubMed:33065002). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (PubMed:33065002).INTERACTION Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level) (PubMed:29993276). Ubiquitous (PubMed:12384298).SIMILARITY Belongs to the V-ATPase G subunit family.
crossReference
databaseName UniProt
dbId 67086
description
  • recommendedName: V-type proton ATPase subunit G 1 shortName: V-ATPase subunit G 1 alternativeName: V-ATPase 13 kDa subunit 1 alternativeName: Vacuolar proton pump subunit G 1 alternativeName: Vacuolar proton pump subunit M16
displayName UniProt:O75348 ATP6V1G1
geneName
  • ATP6V1G1
  • ATP6G
  • ATP6G1
  • ATP6J
identifier O75348
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cell membrane
  • Direct protein sequencing
  • Hydrogen ion transport
  • Ion transport
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Transport
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • ATP6V1G1
otherIdentifier
  • 11731403_a_at
  • 11731404_at
  • 11731405_s_at
  • 11754004_a_at
  • 11754005_x_at
  • 17088401
  • 208737_PM_at
  • 208737_at
  • 238765_PM_at
  • 238765_at
  • 3186192
  • 3186193
  • 3186194
  • 3186195
  • 3186196
  • 3186197
  • 3186201
  • 3186202
  • 3186203
  • 3186204
  • 38814_at
  • 42949_at
  • 43815_at
  • 8157454
  • 82409_at
  • 9550
  • A_14_P114363
  • GE54331
  • GE632813
  • GE85998
  • GO:0000221
  • GO:0005515
  • GO:0005765
  • GO:0005829
  • GO:0005886
  • GO:0006811
  • GO:0006879
  • GO:0016020
  • GO:0016241
  • GO:0016324
  • GO:0016471
  • GO:0016787
  • GO:0016887
  • GO:0030672
  • GO:0033176
  • GO:0033180
  • GO:0036295
  • GO:0046961
  • GO:0051117
  • GO:0055085
  • GO:0070062
  • GO:0097401
  • GO:0098850
  • GO:1902600
  • GO:1904949
  • HMNXSV003040645
  • Hs.136271.0.A1_3p_at
  • ILMN_1784523
  • PH_hs_0005046
  • TC09000584.hg
  • g13097719_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • VATG1_HUMAN
  • Q6IB33
sequenceLength 118
species [Species:48887] Homo sapiens
stId uniprot:O75348
url http://purl.uniprot.org/uniprot/O75348
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