UniProt:O75177 SS18L1

chain
  • chain:1-396
checksum B76B7D61C7DF5592
comment
  • FUNCTION Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).SUBUNIT Homodimer. Dimerization may be necessary for its function in neuronal dendritic development. Interacts (via C-terminus) with CREBBP (via N-terminus), EP300 and SMARCA4/BRG1. Interacts with the nBAF complex. Association with CREBBP facilitates transcription while the association with SMARCA4/BRG1 suppresses CREST-mediated transcription in resting neurons (By similarity).INTERACTION Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity).ALTERNATIVE PRODUCTS Ubiquitous; with lowest levels in spleen.DOMAIN The MFD (multi-functional domain) domain is involved in transcription transactivation, nuclear body targeting and dimerization.SIMILARITY Belongs to the SS18 family.
crossReference
databaseName UniProt
dbId 63982
description
  • recommendedName: Calcium-responsive transactivator alternativeName: SS18-like protein 1 alternativeName: SYT homolog 1
displayName UniProt:O75177 SS18L1
geneName
  • SS18L1
  • CREST
  • KIAA0693
identifier O75177
isSequenceChanged false
keyword
  • Activator
  • Alternative splicing
  • Calcium
  • Centromere
  • Chromatin regulator
  • Chromosome
  • Kinetochore
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • SS18L1
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CREST_HUMAN
  • A6NNE3
  • A8K620
  • B3KWR8
  • E1P5H7
  • Q5JXJ3
  • Q6MZV9
  • Q6NTH3
  • Q6XYD9
  • Q8NE69
  • Q9BR55
  • Q9H4K6
sequenceLength 396
species [Species:48887] Homo sapiens
stId uniprot:O75177
url http://purl.uniprot.org/uniprot/O75177
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