Reactome | UniProt:O60921 HUS1

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UniProt:O60921 HUS1 Show undefined attributes

chain	chain:1-280
checksum	9C3ED2FD35C2ACB3
comment	FUNCTION Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:21659603). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603).SUBUNIT Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1 (PubMed:10359610, PubMed:10777662, PubMed:10846170, PubMed:10884395, PubMed:15314187, PubMed:15556996, PubMed:15871698, PubMed:15897895, PubMed:31776186). The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2 (PubMed:10884395, PubMed:15314187, PubMed:15556996, PubMed:15897895, PubMed:16216273). The 9-1-1 complex associates with the RAD17-RFC complex (PubMed:12578958). HUS1 interacts with POLB, HDAC1, FEN1, PCNA and RAD9B (PubMed:11077446, PubMed:14500360, PubMed:14611806). HUS1 does not interact with RAD17 (PubMed:12578958). Interacts with DNAJC7 (PubMed:11573955).INTERACTION In discrete nuclear foci upon DNA damage (PubMed:11077446). According to PubMed:11077446, localized also in the cytoplasm (PubMed:11077446). DNA damage induces its nuclear translocation (PubMed:11077446). Shuttles between the nucleus and the cytoplasm (PubMed:11077446).ALTERNATIVE PRODUCTS Ubiquitous.SIMILARITY Belongs to the HUS1 family.
created	[InstanceEdit:171274] D'Eustachio, P, 2006-02-02 18:35:12
crossReference	[DatabaseIdentifier:12391865] RefSeq:NP_001350612.1 [DatabaseIdentifier:12391866] RefSeq:NP_004498.1 [DatabaseIdentifier:12293474] Pharos - Targets:O60921 [DatabaseIdentifier:12276641] PRO:O60921 [DatabaseIdentifier:12153878] PDB:3G65 [DatabaseIdentifier:12153877] PDB:3GGR [DatabaseIdentifier:12153880] PDB:3A1J [DatabaseIdentifier:12152391] PDB:8WU8 [DatabaseIdentifier:12152392] PDB:6J8Y [DatabaseIdentifier:12153876] PDB:8GNN [DatabaseIdentifier:12153881] PDB:7Z6H [DatabaseIdentifier:12133305] OpenTargets:ENSG00000136273 [DatabaseIdentifier:11848614] HPA:ENSG00000136273-HUS1 [DatabaseIdentifier:11795647] GeneCards:HUS1 [DatabaseIdentifier:11707925] ENSEMBL:ENST00000432325 [DatabaseIdentifier:11707927] ENSEMBL:ENST00000258774 [DatabaseIdentifier:11707926] ENSEMBL:ENST00000458191 [DatabaseIdentifier:11585227] ENSEMBL:ENSP00000400727 [DatabaseIdentifier:11585228] ENSEMBL:ENSP00000416588 [DatabaseIdentifier:11585226] ENSEMBL:ENSP00000258774 [DatabaseIdentifier:11483265] ENSEMBL:ENSG00000136273
databaseName	UniProt
dbId	171272
description	recommendedName: Checkpoint protein HUS1 shortName: hHUS1
displayName	UniProt:O60921 HUS1
geneName	HUS1
identifier	O60921
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cytoplasm DNA damage Nucleus Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	HUS1
otherIdentifier	11739311_a_at 11739312_a_at 11746197_a_at 17057579 204883_PM_s_at 204883_s_at 204884_3p_s_at 204884_PM_s_at 204884_s_at 217618_3p_x_at 217618_PM_x_at 217618_x_at 3049842 3049843 3049844 3049845 3049846 3049847 3049848 3049849 3049850 3049851 3049852 3049855 3049856 3049858 3049859 3049860 3049861 3049862 3049863 3049864 3049865 3049866 3049867 3364 38153_at 80356_r_at 80446_at 8139592 A_23_P156977 A_24_P932706 A_33_P3330841 GE54702 GO:0000077 GO:0000723 GO:0000724 GO:0005515 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006281 GO:0006289 GO:0006310 GO:0006974 GO:0009314 GO:0009411 GO:0009792 GO:0022414 GO:0030896 GO:0031573 GO:0032200 GO:0033314 GO:0035861 GO:0044778 GO:0048856 GO:0071479 HMNXSV003019403 HMNXSV003031782 Hs.152983.0.S1_3p_a_at Hs.233299.0.A1_3p_x_at ILMN_1670462 ILMN_2136615 PH_hs_0009200 TC07001364.hg TC07002933.hg g4758575_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-176374] HUS1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12743893] UCSC:O60921 HUS1 [ReferenceDNASequence:12117584] OMIM:603760 HUS1 [ReferenceDNASequence:12062544] NCBI Gene:3364 HUS1 [ReferenceDNASequence:11978451] Monarch:3364 HUS1 [ReferenceDNASequence:11888617] KEGG:hsa:3364 HUS1 [ReferenceDNASequence:11827351] HGNC:5309 HUS1 [ReferenceDNASequence:11437473] dbSNP Gene:3364 HUS1 [ReferenceDNASequence:11424661] CTD Gene:3364 HUS1 [ReferenceDNASequence:11400331] COSMIC - genes:HUS1 HUS1 [ReferenceDNASequence:11348662] BioGPS Gene:3364 HUS1 [ReferenceDNASequence:ensembl:ENSG00000136273] ENSEMBL:ENSG00000136273 HUS1
referenceTranscript	[ReferenceRNASequence:12573616] RefSeq:NM_001363683.2 HUS1 [ReferenceRNASequence:12573615] RefSeq:NM_004507.4 HUS1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	HUS1_HUMAN B4DFI9
sequenceLength	280
species	[Species:48887] Homo sapiens
stId	uniprot:O60921
url	http://purl.uniprot.org/uniprot/O60921

Referrals

(interactor)	[UndirectedInteraction:11237709] UniProt:O00560 <-> UniProt:O60921 (IntAct) [UndirectedInteraction:11154743] UniProt:Q03405 <-> UniProt:O60921 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-176374] HUS1 [nucleoplasm]